1.21.3.1: isopenicillin-N synthase

This is an abbreviated version!
For detailed information about isopenicillin-N synthase, go to the full flat file.

Word Map on EC 1.21.3.1

1.21.3.1

chrysogenum

acremonium

penicillium

beta-lactam

tripeptide

cephalosporium

nidulans

clavuligerus

delta-l-alpha-aminoadipoyl-l-cysteinyl-d-valine

deacetoxycephalosporin

pcbab

cephamycins

jumonjinensis

thiazolidine

cipns

lld-acv

penams

lactamdurans

non-haem

daocs

biotechnology

synthesis

pharmacology

medicine

Reaction

N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine

+ 2 H2O

Synonyms

IPN cyclase, IPN synthase, IPNS, isopenicillin N synthase, isopenicillin N synthase (cyclase), isopenicillin N synthetase, isopenicillin N-synthase, isopenicillin-N synthase, isopenicillin-N-synthase, More, PcbC, synthetase, isopenicillin N (9Cl)

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.3 With oxygen as acceptor

1.21.3.1 isopenicillin-N synthase

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Results	in table
32	Activating Compound
57	AA Sequence
5	Application
1	CAS Registry Number
14	Cloned(Commentary)
13	Crystallization (Commentary)
3	Expression
2	General Information
1	General Stability
52	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
11	Localization
30	Metals/Ions
4	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
93	Organism
1	Oxidation Stability
4	Pathway
45	PDB ID
3	pH Optimum
2	pH Range
51	Protein Variants
12	Purification (Commentary)
17	Reaction
32	Reaction Type
69	Reference
1	Renatured (Commentary)
1	Source Tissue
17	Specific Activity [micromol/min/mg]
123	Substrates and Products (Substrate)
6	Subunits
104	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Turnover Number [1/s]

KM Value

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KM Value on EC 1.21.3.1 - isopenicillin-N synthase

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0.08 - 0.18

delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine

2 entries

0.12 - 0.18

N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine

2 entries

3.6

phenylacetyl-L-cysteinyl-D-valine

Actinomyces sp.

700004

additional information

N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine

Actinomyces sp.

Km values for ACV exhibit for different cyclases are on the order of 0.2-0.3 mM

700004