2.1.1.14: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase

This is an abbreviated version!
For detailed information about 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.14

2.1.1.14

methyltetrahydrofolate

cobalamin-dependent

tetrahydrofolate

n5-methyl

overoxidation

s-bacillithiolation

bacillithiol

analysis

Reaction

5-methyltetrahydropteroyltri-L-glutamate

Synonyms

5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase, AtMetE, cobalamin-independent methionine synthase, cobalamin-independent methionine synthase (MetE), homocysteine methylase, Met-8, MET1, Met6, Met6p, MetE, methionine synthase MetE, methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase, methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase, MS1, PpMetE, tetrahydropteroyltriglutamate methyltransferase, TM1286

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.14 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase

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Results	in table
21975	AA Sequence
2	Application
1	CAS Registry Number
14	Cloned(Commentary)
42	Cofactor
9	Crystallization (Commentary)
2	Expression
9	General Information
23	Inhibitors
25	KM Value [mM]
9	Localization
47	Metals/Ions
9	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
58	Organism
1	Oxidation Stability
12	Pathway
36	PDB ID
9	pH Optimum
3	pH Range
1	pI Value
14	Protein Variants
11	Purification (Commentary)
9	Reaction
2	Reaction Type
56	Reference
18	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
66	Substrates and Products (Substrate)
6	Subunits
56	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Temperature Stability [°C]
11	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.1.1.14 - 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase

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5-methyltetrahydropteroyl-alpha-glutamate

Chloromethyl ketones

Diamide

EDTA

GSSG

inactivates by glutathionylation at Cys645

high ionic strength

iodoacetamide

methionine

Mn2+

above 1 mM

Pteroyl-alpha-glutamylglutamic acid

Escherichia coli

441323

Pteroyl-gamma-glutamyl-gamma-glutamylglutamic acid

Escherichia coli

441323

Zinc

Arabidopsis thaliana

His647, Cys649 and Cys733 are involved in zinc coordination. Addition of L-homocysteine leads to reorganization of the zinc binding site with a stronger coordination to Cys649, Cys733, and a water molecule

659400