2.1.1.184: 23S rRNA (adenine2085-N6)-dimethyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (adenine2085-N6)-dimethyltransferase, go to the full flat file.
Word Map on EC 2.1.1.184
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2.1.1.184
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macrolide
-
macrolide-lincosamide-streptogramin
-
methyltransferases
-
lincosamide
-
unmethylated
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mtases
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streptogramine
-
medicine
- 2.1.1.184
-
macrolide
-
macrolide-lincosamide-streptogramin
- methyltransferases
-
lincosamide
-
unmethylated
- mtases
-
streptogramine
- medicine
Reaction
2 S-adenosyl-L-methionine
+
Synonyms
23S ribosomal RNA adenine N-6 methyltransferase, EC 2.1.1.48, ErmC, ermC 23 S rRNA methyltransferase, ErmC 23S rRNA methyltransferase, ermC methylase, ErmC methyltransferase, ErmC', ErmC' methyltransferase, ErmC' MTase, erythromycin resistance protein, rRNA methyltransferase ErmC', rRNA:m6A methyltransferase ErmC'
ECTree
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Reference on EC 2.1.1.184 - 23S rRNA (adenine2085-N6)-dimethyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Denoya, C.; Dubnau, D.
Site and substrate specificity of the ermC 23S rRNA methyltransferase
J. Bacteriol.
169
3857-3860
1987
Bacillus subtilis (P13956), Bacillus subtilis
Denoya, C.; Dubnau, D.
Mono- and dimethylating activities and kinetic studies of the ermC 23 S rRNA methyltransferase
J. Biol. Chem.
264
2615-2624
1989
Bacillus subtilis (P13956), Bacillus subtilis BD170 (P13956)
Bussiere, D.E.; Muchmore, S.W.; Dealwis, C.G.; Schluckebier, G.; Nienaber, V.L.; Edalji, R.P.; Walter, K.A.; Ladror, U.S.; Holzman, T.F.; Abad-Zapatero, C.
Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria
Biochemistry
37
7103-7112
1998
Bacillus subtilis (P13956), Bacillus subtilis
Maravic, G.; Feder, M.; Pongor, S.; Flogel, M.; Bujnicki, J.M.
Mutational analysis defines the roles of conserved amino acid residues in the predicted catalytic pocket of the rRNA:m6A methyltransferase ErmC'
J. Mol. Biol.
332
99-109
2003
Bacillus subtilis (P13956), Bacillus subtilis BD1167 (P13956)
Su, S.L.
Dubnau, D.: Binding of Bacillus subtilis ermC' methyltransferase to 23S rRNA
Biochemistry
29
6033-6042
1990
Bacillus subtilis (P13956), Bacillus subtilis
Feder, M.; Purta, E.; Koscinski, L.; Ebrilo, S.; Vlahovicek, G.; Bujnicki, J.
Virtual screening and experimental verification to identify potential inhibitors of the ErmC methyltransferase responsible for bacterial resistance against macrolide antibiotics
ChemMedChem
3
316-322
2008
Bacillus subtilis (P13956)
Denoya, C.D.; Bechhofer, D.H.; Dubnau, D.
Translational autoregulation of ermC 23S rRNA methyltransferase expression in Bacillus subtilis
J. Bacteriol.
168
1133-1141
1986
Bacillus subtilis (P13956), Bacillus subtilis
Kadam, S.K.
Induction of ermC methylase in the absence of macrolide antibiotics and by pseudomonic acid A
J. Bacteriol.
171
4518-4520
1989
Bacillus subtilis (P13956)
Zhong, P.; Pratt, S.D.; Edalji, R.P.; Walter, K.A.; Holzman, T.F.; Shivakumar, A.G.; Katz, L.
Substrate requirements for ErmC' methyltransferase activity
J. Bacteriol.
177
4327-4332
1995
Bacillus subtilis (P13956), Bacillus subtilis
Schluckebier, G.; Zhong, P.; Stewart, K.D.
Kavanaugh, T.J.; Abad-Zapatero, C.: The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism
J. Mol. Biol.
289
277-291
1999
Bacillus subtilis (P13956)
Maravic, G.; Bujnicki, J.M.; Feder, M.; Pongor, S.; Flögel, M.
Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC' redefines the substrate-binding site and suggests a model for protein-RNA interactions
Nucleic Acids Res.
31
4941-4949
2003
Bacillus subtilis (P13956), Bacillus subtilis BD1167 (P13956)
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