2.1.1.216: tRNA (guanine26-N2)-dimethyltransferase
This is an abbreviated version!
For detailed information about tRNA (guanine26-N2)-dimethyltransferase, go to the full flat file.
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
EC 2.1.1.32, Ta0997, transfer RNA methyltransferase, Trm1, Trm1 methyltransferase, Trm1p, tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA (m22G26)dimethyltransferase, tRNA(guanine-26,N2-N2) methyltransferase, tRNA(guanine26,N2,N2)-dimethyltransferase, tRNA(m22G26)dimethyltransferase, ZC376.5
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 2.1.1.216 - tRNA (guanine26-N2)-dimethyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
2 S-adenosyl-L-methionine + guanine26 in tRNA
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
2 S-adenosyl-L-methionine + guanine26 in tRNA
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 tRNA
-
the efficient dimethylation of guanine26 requires the presence of base-pairs C11*G24 and G10*C25 and a variable loop of five bases within a correct 3D-core of the tRNA molecule. These identity elements probably ensure the correct presentation of methylated m2G26 to the enzyme for the attachment of the second methyl group
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNALeu(UAG)
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeu(UAG)
4 S-adenosyl-L-methionine + guanine26 in initiator tRNAMet
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in initiator tRNAMet
m2G26 and m22G26 are formed by Trm1
-
-
?
4 S-adenosyl-L-methionine + guanine26 in prolongator tRNAMet
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in prolongator tRNAMet
m2G26 and m22G26 are formed by Trm1
-
-
?
4 S-adenosyl-L-methionine + guanine26 in tRNA
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
4 S-adenosyl-L-methionine + guanine26 in tRNALeuCAA
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeuCAA
-
-
-
-
?
4 S-adenosyl-L-methionine + guanine26 in tRNALeuTAG
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeuTAG
-
-
-
-
?
4 S-adenosyl-L-methionine + guanine26 in tRNASerUCA
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNASerUCA
-
-
-
-
?
S-adenosyl-L-methionine + 2'-O-methylguanine26 in elongator tRNAMet
S-adenosyl-L-homocysteine + 2'-O-dimethylguanine26 in elongator tRNAMet
-
-
-
?
S-adenosyl-L-methionine + 2'-O-methylguanine26 in initiator tRNAMet
S-adenosyl-L-homocysteine + 2'-O-dimethylguanine26 in initiator tRNAMet
-
-
-
?
S-adenosyl-L-methionine + guanine26 in elongator tRNAMet
S-adenosyl-L-homocysteine + 2'-O-methylguanine26 in elongator tRNAMet
-
-
-
?
S-adenosyl-L-methionine + guanine26 in initiator tRNAMet
S-adenosyl-L-homocysteine + 2'-O-methylguanine26 in initiator tRNAMet
-
-
-
?
S-adenosyl-L-methionine + guanine26 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine26 in tRNA
S-adenosyl-L-methionine + N2-methylguanine26 in tRNA
S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNA
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNA
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNA
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNA
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNA
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNA
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeu(UAG)
-
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNALeu(UAG)
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeu(UAG)
-
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNALeu(UAG)
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeu(UAG)
-
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNALeu(UAG)
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeu(UAG)
-
-
-
?
2 S-adenosyl-L-methionine + guanine26 in tRNALeu(UAG)
2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNALeu(UAG)
-
-
-
?
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
G26 is modified by N2,N2-dimethylation in many tRNAs by the Trm1 methyltransferase
-
-
?
4 S-adenosyl-L-methionine + guanine26 in tRNA
4 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
G modification at position 26 is a mixture of m2G and m22G generated by Trm1
-
-
?
S-adenosyl-L-homocysteine + N2-methylguanine26 in tRNA
-
-
-
-
?
S-adenosyl-L-methionine + guanine26 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine26 in tRNA
-
-
-
?
S-adenosyl-L-methionine + guanine26 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine26 in tRNA
-
-
-
?
S-adenosyl-L-methionine + guanine26 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine26 in tRNA
-
-
-
?
S-adenosyl-L-methionine + guanine26 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine26 in tRNA
-
-
-
?
S-adenosyl-L-methionine + guanine26 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine26 in tRNA
-
-
-
?
S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
the efficient dimethylation of guanine26 requires the presence of base-pairs C11*G24 and G10*C25 and a variable loop of five bases within a correct 3D-core of the tRNA molecule. These identity elements probably ensure the correct presentation of methylated m2G26 to the enzyme for the attachment of the second methyl group
-
-
?
S-adenosyl-L-methionine + N2-methylguanine26 in tRNA
S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?
S-adenosyl-L-methionine + N2-methylguanine26 in tRNA
S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?
S-adenosyl-L-methionine + N2-methylguanine26 in tRNA
S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?
S-adenosyl-L-methionine + N2-methylguanine26 in tRNA
S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?
S-adenosyl-L-methionine + N2-methylguanine26 in tRNA
S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
-
-
?