2.1.1.280: selenocysteine Se-methyltransferase
This is an abbreviated version!
For detailed information about selenocysteine Se-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.280
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2.1.1.280
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selenium
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selenate
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astragalus
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se-methylselenocysteine
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hyperaccumulator
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bisulcatus
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brassica
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oleracea
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mesecys
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homocysteine
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methylselenocysteine
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phytoremediation
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sulfurylase
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non-accumulating
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broccoli
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mustard
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agriculture
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juncea
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italica
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brassicaceae
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organoselenium
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s-methylmethionine
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nonprotein
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chemopreventative
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biofortification
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synthesis
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fabaceae
- 2.1.1.280
- selenium
- selenate
- astragalus
- se-methylselenocysteine
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hyperaccumulator
- bisulcatus
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brassica
- oleracea
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mesecys
- homocysteine
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methylselenocysteine
-
phytoremediation
-
sulfurylase
-
non-accumulating
- broccoli
- mustard
- agriculture
- juncea
- italica
- brassicaceae
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organoselenium
- s-methylmethionine
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nonprotein
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chemopreventative
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biofortification
- synthesis
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fabaceae
Reaction
Synonyms
BjSMT, BoSMT, Hcy methyltransferase, SEcMT, SeCys-methyltransferase, SeCys-MT, selenocysteine methyltransferase, SMT, smtA, YagD, YagD protein
ECTree
2.1.1.280 selenocysteine Se-methyltransferaseAdvanced search results
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results (General Information
General Information on EC 2.1.1.280 - selenocysteine Se-methyltransferase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
malfunction
metabolism
physiological function
additional information
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the post-secondary structure assembled by conserved Cys207, Cys272, and Cys273 residues is believed to form such a geometrical catalytic pocket which will position the sulfur group of L-homocysteine in close proximity to Thr147, responsible for methyl group transfer by donating a hydrogen bond
malfunction
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overexpression of SMT decreases the negative effect of selenium on sulforaphane synthesis, while knockdown of SMT by RNAi enhances the negative effect
malfunction
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overexpression of BjSMT in tobacco substantially enhances tolerance to selenite stress manifested as significantly higher fresh weight, plant height, and chlorophyll content than control plants. The BjSMT-transformed tobacco plants accumulate a high level of Se upon selenite stress, and the plants also have significantly increased MeSeCys production potential in their leaves. The enzyme is highly induced by selenite and especially selenate. BjSMT overexpressing plants maintain a higher level of GSH-Px activity and chlorophyll content under severe selenite treatment
malfunction
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overexpression of SMT decreases the negative effect of selenium on sulforaphane synthesis, while knockdown of SMT by RNAi enhances the negative effect
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metabolism
enzyme plays a crucial role in the detoxification of selenium in Astragalus bisulcatus
metabolism
SMT is the key enzyme for Se-methylselenocysteine synthesis
metabolism
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an increase of SMT gene expression leads to a rise in APX and POX, but a suppression of CAT and GR enzymes activities in Astragalus chrysochlorus. Selenium might be involved in the antioxidant metabolism in Astragalus chrysochlorus
physiological function
expression of BoSMT significantly enhances Se tolerance, high levels of Se accumulate in Broccoli plants exposed to selenate, but addition of high levels of 1 or 10 mM sulfate shows a strong inhibitory effect on Se accumulation
physiological function
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compared to wild type, ATP sulfurylase and selenocysteine methyltransferase, expressing plants also accumulate increased concentrations of selenium when treated with selenite. Selenocysteine methyltransferase, is able to carry out Se phytoremediation more efficiently when the plants are supplied with selenium in the form of selenate
physiological function
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selenocysteine methyltransferase plays a critical role in the Se/S metabolism system. The enzyme plays a key role in sulforaphane synthesis in a selenium-rich environment
physiological function
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plants can easily absorb and assimilate Se in the form of selenate and selenite through sulfur transport proteins and metabolic pathways and remove it by converting it into volatilized methylated forms. The Se substitution of S in proteins can destroy the molecular function of these proteins, so an increased level of Se is toxic to most organisms. In plants,selenates are reduced and assimilated to organic Se which can be converted to methylselenocysteine (MeSeCys) in addition to selenocysteine (SeCys), selenomethionine (SeMet), and dimethylselenide (DMSe). Selenocysteine methyltransferase (SMT) is the key enzyme responsible for Se-methylselenocysteine (MeSeCys) formation. Brassica juncea is a selenium accumulator. BjSMT also possesses a conserved Thr187 which is involved in transferring a methyl group to L-homocysteine (HoCys) by donating a hydrogen bond, suggesting that BjSMT can methylate both HoCys and SeCys substrates
physiological function
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selenocysteine methyltransferase (SMT) is responsible for forming methylselenocysteine (MeSeCys)
physiological function
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selenocysteine methyltransferase plays a critical role in the Se/S metabolism system. The enzyme plays a key role in sulforaphane synthesis in a selenium-rich environment
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