2.1.1.299: protein N-terminal monomethyltransferase

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For detailed information about protein N-terminal monomethyltransferase, go to the full flat file.

Word Map on EC 2.1.1.299

2.1.1.299

methyltransferases

trimethylation

monomethylated

trimethylase

priming

Reaction

N-terminal-N-methyl-N-(A,P,S)PK-[protein]

Synonyms

alpha N-terminal protein methyltransferase 1B, alpha-N-terminal methyltransferase 2, METTL11B, N-terminal methyltransferase, N-terminal monomethylase, N-terminal RCC1 methyltransferase 2, NRMT2, NTMT2

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.299 protein N-terminal monomethyltransferase

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Results	in table
5	AA Sequence
3	Cloned(Commentary)
3	Cofactor
3	Crystallization (Commentary)
9	General Information
1	KM Value [mM]
4	Localization
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
5	Organism
6	PDB ID
4	Protein Variants
1	Purification (Commentary)
1	Reaction
5	Reference
8	Source Tissue
26	Substrates and Products (Substrate)
3	Subunits
16	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

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Reference on EC 2.1.1.299 - protein N-terminal monomethyltransferase

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724242

Petkowski, J.J.; Bonsignore, L.A.; Tooley, J.G.; Wilkey, D.W.; Merchant, M.L.; Macara, I.G.; Schaner Tooley, C.E.

NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1

Biochem. J.

456

453-462

2013

Mus musculus, Homo sapiens (Q5VVY1), Homo sapiens

24090352

756463

Huang, R.

Chemical biology of protein N-terminal methyltransferases

ChemBioChem

976-984

2019

Homo sapiens (Q5VVY1)

30479015

756502

Dong, C.; Dong, G.; Li, L.; Zhu, L.; Tempel, W.; Liu, Y.; Huang, R.; Min, J.

An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2

Commun. Biol.

183

2018

Homo sapiens (Q5VVY1), Homo sapiens

30417120

758296

Faughn, J.D.; Dean, W.L.; Schaner Tooley, C.E.

The N-terminal methyltransferase homologs NRMT1 and NRMT2 exhibit novel regulation of activity through heterotrimer formation

Protein Sci.

1585-1599

2018

Homo sapiens (Q5VVY1)

30151928