2.1.1.314: diphthine methyl ester synthase

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For detailed information about diphthine methyl ester synthase, go to the full flat file.

Reaction

4 S-adenosyl-L-methionine +

Synonyms

diphthine methyltransferase, diphthine synthase, Dph5, S-adenosyl-L-methionine:elongation factor 2 methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.314 diphthine methyl ester synthase

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Results	in table
3230	AA Sequence
1	Cloned(Commentary)
11	General Information
2	Localization
7	Natural Substrates/ Products (Substrates)
14	Organism
1	Pathway
8	Protein Variants
1	Reaction
12	Reference
2	Source Tissue
15	Substrates and Products (Substrate)
15	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.1.1.314 - diphthine methyl ester synthase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] methyltransferase (diphthine methyl ester-[translation elongation factor 2]-forming)

This eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. Different from the archaeal enzyme, which performs only 3 methylations, producing diphthine (cf. EC 2.1.1.98). The relevant histidine of elongation factor 2 is His715 in mammals and His699 in yeast. The order of the 4 methylations is not known.