Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
-
PIMT-knockdown cells show significant accumulation of proteins with isomerized residues, compared to control cells
malfunction
-
reduced PIMT1 accumulation leads to heightened sensitivity to aging treatments and loss of seed vigor under stressful germination conditions
malfunction
-
enzyme depletion upregulates the proapoptotic and checkpoint activation functions of p53
malfunction
-
seed deterioration and loss of viability result from a decrease in enzyme activity
malfunction
-
silencing enzym expression results in the accumulation of proteins with racemized or isomerized Asp residues. Suppression of enzyme expression leads to epidermal growth factor-stimulated hyperactivation of the MAP-kinase
malfunction
-
dopamine-associated enzyme downregulation leads to neuronal cell apoptosis
malfunction
-
enzyme down-regulation in HUVEC cells inhibits both cell migration and tube formation in vitro when stimulated by vascular endothelial growth factor
malfunction
-
enzyme inhibition suppresses basic fibroblast growth factor-mediated neuronal differentiation of PC-12 cells. Enzyme deficiency inhibits neuronal differentiation of PC-12 cells by suppressing phosphorylation of MEK1/2 and ERK1/2 in the MAPK signaling pathway and Akt and mTOR in the PI3K/Akt signaling pathway
malfunction
-
in comparison to wild type, the enzyme deletion strain is found significantly more susceptible to H2O2 (4fold at 2.5 mM) and hypochlorite (90fold at 0.2 mM). Further, the enzyme deletion mutant strain shows hypersusceptibility to interferon-gamma stimulated macrophages
malfunction
-
in comparison to wild type, the enzyme deletion strain is found significantly more susceptible to H2O2 (4fold at 2.5 mM) and hypochlorite (90fold at 0.2 mM). Further, the enzyme deletion mutant strain shows hypersusceptibility to interferon-gamma stimulated macrophages
-
physiological function
-
PCMT maintains the functional stability of antiapoptotic proteins, PCMT when overexpressed in endothelial cells is able to prevent apoptosis induced by H2O2 treatment
physiological function
-
PCMT1 repairs proteins that have been damaged by deamidation of asparagine or isomerization of aspartate, resulting in the spontaneous generation of L-isoaspartyl residues within peptides and proteins during aging
physiological function
-
PIMT repair of abnormal proteins is necessary to maintain normal mitogen-activated protein kinase signaling
physiological function
-
PIMT repairs L-iso-Asp sites in aged nucleosomes
physiological function
-
PIMT repairs L-iso-Asp sites in aged nucleosomes
physiological function
-
PIMT1 improves longevity and vigor of seeds, PIMT1 overaccumulation reduces the accumulation of L-isoaspartyl residues in seed proteins and increases both seed longevity and germination vigor
physiological function
PIMT1 may have a specifc role in stress adaptation apart from seed
physiological function
-
worms lacking the pcm-1 gene exhibit reduced longevity as SDS-isolated dauer larvae and as arrested L1 larvae under starvation stress, while overexpression leads to increased adult longevity
physiological function
-
enzyme overexpressor adult animals display increased resistance to severe thermal stress (37°C). The enzyme plays a signaling role in lifespan extension that involves the insulin/insulin-like growth factor-1 signaling pathway, but is independent of its function in overall protein repair. Enzyme overexpression extends lifespan in a DAF-16-dependent manner under mild thermal stress (25°C)
physiological function
-
protein L-isoaspartyl/D-aspartyl O-methyltransferase is a repair enzyme that initiates the conversion of L-isoaspartyl (or D-Asp) residues to L-aspartyl residues. Isomerization of Asn or Asp residues, and the repair of atypical residues by PIMT plays a role in the posttranslational regulation of protein activity. The repair of abnormal residues by the enzyme is essential for maintenance of the central nervous system
physiological function
-
the enzyme negatively regulates the tumour suppressor protein p53 by reducing p53 protein levels, thereby suppressing the p53-mediated transcription of target genes. The enzyme destabilizes p53 by enhancing the p53-HDM2 interaction
physiological function
isoform PIMT1 enhances seed vigor and longevity by repairing such abnormal proteins mainly in the cytosolic fraction
physiological function
isoform PIMT2 enhances seed vigor and longevity by repairing abnormal isoaspartyl residues predominantly in nuclear proteins upon seed-specific expression
physiological function
-
the enzyme acts as a co-activator for estrogen receptor alpha-mediated transcription. Over-expression of the enzyme significantly increases the levels of trefoil factor 1 mRNA in the presence or absence of beta-estradiol
physiological function
-
the enzyme improves seed longevity by preserving embryo vigor and viability
physiological function
-
the enzyme is an inhibitor of hypoxia/reoxygenation-induced activation of mammalian sterile 20-like kinase 1 and cell apoptosis in cardiomyocytes
physiological function
-
by repairing iso-Asp to Asp, the enzyme maintains the activities of proteins and thus helps in cellular survival under oxidative stress
physiological function
-
enzyme activity is important to reduce stress-induced iso-Asp accumulation which otherwise affects plant growth and development and survivability under stress conditions. The enzyme restricts reactive oxygen species accumulation and lipid peroxidation during heat and oxidative stresses, by protecting functionality of antioxidant enzymes, and improves stress tolerance. Transgenic plants expressing either isoform PIMT1 or PIMT2 show increased stress tolerance, and survive better than the wild type plants under heat (37°C) and oxidative stress (H2O2) conditions
physiological function
-
enzyme overexpression protects SH-SY5Y cells from cell death and caspase 3 activation upon dopamine treatments. Cells overexpressing enzyme produce significantly less reactive oxygen species despite dopamine treatment
physiological function
-
the enzyme has a protective role for maintenance of mitochondrial morphology in A-549 cells
physiological function
-
the enzyme is critical for basic fibroblast growth factor-mediated neuronal differentiation of PC-12 cells and regulates the MAPK and Akt signaling pathways
physiological function
-
the enzyme is crucial for survival, virulence and colonization of Salmonella Typhimurium in poultry
physiological function
-
the enzyme is required for survival of Salmonella Typhimurium at 42°C and contributes to the virulence in poultry
physiological function
-
the enzyme is required for vascular endothelial growth factor-dependent endothelial cell migration and tubulogenesis. Enzyme overexpression promotes angiogenic properties in HUVEC cells
physiological function
-
the enzyme plays a critical role in repairing isomerized Asp residues in the cortex of lenses
physiological function
-
the enzyme repairs antioxidative enzymes and proteins which restrict reactive oxygen species accumulation, lipid peroxidation, etc. in seed, particularly during aging, thus contributing to seed vigor and longevity
physiological function
-
the enzyme is required for survival of Salmonella Typhimurium at 42°C and contributes to the virulence in poultry
-
physiological function
-
enzyme overexpressor adult animals display increased resistance to severe thermal stress (37°C). The enzyme plays a signaling role in lifespan extension that involves the insulin/insulin-like growth factor-1 signaling pathway, but is independent of its function in overall protein repair. Enzyme overexpression extends lifespan in a DAF-16-dependent manner under mild thermal stress (25°C)
-
physiological function
-
enzyme overexpressor adult animals display increased resistance to severe thermal stress (37°C). The enzyme plays a signaling role in lifespan extension that involves the insulin/insulin-like growth factor-1 signaling pathway, but is independent of its function in overall protein repair. Enzyme overexpression extends lifespan in a DAF-16-dependent manner under mild thermal stress (25°C)
-
physiological function
-
by repairing iso-Asp to Asp, the enzyme maintains the activities of proteins and thus helps in cellular survival under oxidative stress
-