2.1.1.8: histamine N-methyltransferase

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For detailed information about histamine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

histamine 1-methyltransferase, histamine methyltransferase, histamine N-methyltransferase, histamine-methylating enzyme, histamine-N-methyltransferase, HMT, HNMT, imidazole methyltransferase, imidazole N-methyltransferase, imidazolemethyltransferase, methyltransferase, histamine, Ntau-methyltransferase, S-adenosylmethionine-histamine N-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.8 histamine N-methyltransferase

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8	Activating Compound
280	AA Sequence
10	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
299	Disease/ Diagnostics
1	Expression
1	General Information
1	General Stability
114	Inhibitors
7	Ki Value [mM]
29	KM Value [mM]
5	Localization
11	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
66	Organism
3	Pathway
12	PDB ID
15	pH Optimum
2	pH Range
17	Protein Variants
16	Purification (Commentary)
5	Reaction
2	Reaction Type
66	Reference
138	Source Tissue
21	Specific Activity [micromol/min/mg]
5	Storage Stability
51	Substrates and Products (Substrate)
13	Subunits
37	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
7	Temperature Stability [°C]
4	Turnover Number [1/s]

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General Information on EC 2.1.1.8 - histamine N-methyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

Mus musculus

Q91VF2

in HNMT knockout mice, HNMT deficiency enhances brain histamine concentrations. The mice exhibit highly aggressive behaviours in the resident-intruder and aggressive biting behaviour tests. Aggression is suppressed by treatment with zolantidine, a histamine H2 receptor (H2R) antagonist. Knockout mice exhibit prolonged bouts of awakening during the light (inactive) period and compensatorysleep during the dark (active) period. Abnormal sleep behaviour is suppressed by treatment with pyrilamine, a H1R antagonist, prior to light period

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