2.1.1.B3: sialate-8-O-methyltransferase
This is an abbreviated version!
For detailed information about sialate-8-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
S-adenosyl-L-methionine: sialate-8-O-methyltransferase, sialate-8-O-methyltransferase
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.B3 - sialate-8-O-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + CMP-N-acetylneuraminic acid
S-adenosyl-L-homocysteine + CMP-N-acetyl-8-O-methyl-neuraminate
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?
S-adenosyl-L-methionine + N-acetylneuraminic acid
S-adenosyl-L-homocysteine + N-acetyl-8-O-methyl-neuraminate
S-adenosyl-L-methionine + N-acetylneuraminyl alpha2,3-lactose
S-adenosyl-L-homocysteine + N-acetyl-8-O-methyl-neuraminyl alpha2,3-lactose
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free N-acetylneuraminyl alpha2,3-lactose and oligosaccharide- or glycoprotein-bound substrate, the latter is preferred
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?
S-adenosyl-L-methionine + N-acetylneuraminyl alpha2,6-lactose
S-adenosyl-L-homocysteine + N-acetyl-8-O-methyl-neuraminyl alpha2,6-lactose
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free N-acetylneuraminyl alpha2,6-lactose acid and oligosaccharide- or glycoprotein-bound substrate, the latter is preferred
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?
S-adenosyl-L-methionine + N-glycoloylneuraminic acid
S-adenosyl-L-homocysteine + N-glycoloyl-8-O-methyl-neuraminate
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free N-glycoloylneuraminic acid and oligosaccharide- or glycoprotein-bound substrate, the latter is preferred
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?
additional information
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the enzyme preforms specific methylation of endogenous and exogenous glycoconjugate-bound sialic acids, usage of desialized human erythrocyte membranes as substrates, methylation of resialylated erythrocyte membranes, overview
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S-adenosyl-L-homocysteine + N-acetyl-8-O-methyl-neuraminate
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?
S-adenosyl-L-methionine + N-acetylneuraminic acid
S-adenosyl-L-homocysteine + N-acetyl-8-O-methyl-neuraminate
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free N-acetylneuraminic acid and oligosaccharide- or glycoprotein-bound substrate, the latter is preferred
NMR product identification
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