2.3.1.111: mycocerosate synthase

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For detailed information about mycocerosate synthase, go to the full flat file.

Word Map on EC 2.3.1.111

2.3.1.111

mycobacterium

bovis

tuberculosis

synthases

smegmatis

polyketide

acyl-coa

phthiocerol

dimycocerosate

n-fatty

esterify

kolattukudy

methyl-branched

beta-ketoacyl

resequenced

hygromycin-resistant

synthase-like

crossover

iterative

phenolphthiocerol

fadd28

rainwater

slow-growing

Reaction

a long-chain acyl-[mycocerosic acid synthase]

+ 3 methylmalonyl-CoA + 6 NADPH + 6 H+ =

a trimethylated-mycocerosoyl-[mycocerosate synthase]

+ 3 CoA + 3 CO2 + 6 NADP⁺ + 3 H2O

Synonyms

mycocerosic acid synthase, Pks5

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.111 mycocerosate synthase

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Results	in table
377	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
1	General Stability
3	Inhibitors
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
8	Organism
2	Pathway
31	PDB ID
1	pH Optimum
4	Purification (Commentary)
2	Reaction
2	Reaction Type
8	Reference
1	Specific Activity [micromol/min/mg]
1	Storage Stability
12	Substrates and Products (Substrate)
2	Subunits
3	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.3.1.111 - mycocerosate synthase

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long-chain acyl-[mycocerosic acid synthase]:methylmalonyl-CoA C-acyltransferase (mycocerosate-forming)

The enzyme, characterized from mycobacteria, is loaded with a long-chain acyl moiety by EC 6.2.1.49, long-chain fatty acid adenylyltransferase FadD28, and elongates it by incorporation of three or four methylmalonyl (but not malonyl) residues, to form tri- or tetramethyl-branched fatty-acids, respectively, such as 2,4,6,8-tetramethyloctacosanoate (C32-mycocerosate). Since the enzyme lacks a thioesterase domain, the product remains bound and requires additional enzyme(s) for removal. Even though the enzyme can accept C6 to C20 substrates in vitro, it prefers to act on C14-C20 substrates in vivo.