2.3.1.28: chloramphenicol O-acetyltransferase
This is an abbreviated version!
For detailed information about chloramphenicol O-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.28
-
2.3.1.28
-
5'-flanking
-
cotransfection
-
cis-acting
-
tata
-
transactivation
-
sp1
-
footprint
-
simian
-
thymidine
-
hepatoma
-
immunodeficiency
-
camp
-
glucocorticoid
-
dnase
-
dexamethasone
-
phorbol
-
herpes
-
trans-acting
-
simplex
-
viruses
-
sarcoma
-
adenovirus
-
c-fos
-
nuclease
-
ccaat
-
promoterless
-
cytomegalovirus
-
electroporation
-
nf-kappa
-
jurkat
-
run-on
-
dna-protein
-
immediate-early
-
e1a
-
5'-deletion
-
gc-rich
-
12-o-tetradecanoylphorbol-13-acetate
-
5\'-upstream
-
camp-responsive
-
supershifted
-
polyhedrosis
-
mobility-shift
-
estrogen-responsive
-
subgenomic
-
htlv-i
-
sp1-binding
-
glucocorticoid-responsive
-
basepairs
-
moloney
-
analysis
-
molecular biology
-
medicine
-
proviruses
-
biotechnology
-
synthesis
-
pharmacology
- 2.3.1.28
-
5'-flanking
-
cotransfection
-
cis-acting
- tata
-
transactivation
- sp1
-
footprint
-
simian
- thymidine
- hepatoma
- immunodeficiency
- camp
- glucocorticoid
- dnase
- dexamethasone
-
phorbol
-
herpes
-
trans-acting
- simplex
- viruses
- sarcoma
- adenovirus
- c-fos
- nuclease
-
ccaat
-
promoterless
- cytomegalovirus
-
electroporation
-
nf-kappa
-
jurkat
-
run-on
-
dna-protein
-
immediate-early
- e1a
-
5'-deletion
-
gc-rich
- 12-o-tetradecanoylphorbol-13-acetate
-
5\'-upstream
-
camp-responsive
-
supershifted
-
polyhedrosis
-
mobility-shift
-
estrogen-responsive
-
subgenomic
- htlv-i
-
sp1-binding
-
glucocorticoid-responsive
-
basepairs
-
moloney
- analysis
- molecular biology
- medicine
- proviruses
- biotechnology
- synthesis
- pharmacology
Reaction
Synonyms
acetyltransferase, chloramphenicol, CAP acetyltransferase, CAT, CAT I, CAT II, CAT III, cat-86, CATC, CATI, chloramphenicol acetylase, chloramphenicol acetyltransferase, chloramphenicol acetyltransferase B2, chloramphenicol transacetylase, Pacat, Tn9 ca
ECTree
2.3.1.28 chloramphenicol O-acetyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.28 - chloramphenicol O-acetyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 acetyl-CoA + chloramphenicol
2 CoA + chloramphenicol 1,3-diacetate
-
-
-
-
?
chloramphenicol + acetyl-CoA
chloramphenicol 3-acetate + CoA
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
inducible enzyme
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
inducible enzyme
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
in forward reaction formation of a ternary complex by a rapid-equilibrium mechanism, in reverse reaction rapid-equilibrium mechanism with random addition of substrates
-
r
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
catabolite repression of CAT synthesis is mediated by a mechanism involving cyclic adenosine 5'-monophosphate
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
inactivates chloramphenicol
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
enzymatic inactivation of chloramphenicol
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
all known R factors carrying the CAT gene in enteric bacteria mediate constitutive synthesis of the enzyme
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
in forward reaction formation of a ternary complex by a rapid-equilibrium mechanism, in reverse reaction rapid-equilibrium mechanism with random addition of substrates
-
r
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
acetylates only the biologically active D-threo stereoisomer
+ chloramphenicol 1,3-diacetate
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
inducible enzyme
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
inactivates chloramphenicol
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
acetylates only the biologically active D-threo stereoisomer
+ chloramphenicol 1,3-diacetate
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
inducible enzyme
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
inactivates chloramphenicol
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
inducible enzyme
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
inducible enzyme
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol
CoA + chloramphenicol 3-acetate
-
-
-
?
acetyl-CoA + chloramphenicol 1-acetate
CoA + chloramphenicol 1,3-diacetate
-
the enzyme acetylates specifically at the 3-hydroxy position. The diacetylation is possible only because of non-enzymatic interconversion of chloramphenical 3-acetate to chloramphenicol 1-acetate at higher pH values
-
?
acetyl-CoA + chloramphenicol 1-acetate
CoA + chloramphenicol 1,3-diacetate
-
no activity
-
-
?
acetyl-CoA + chloramphenicol 1-acetate
CoA + chloramphenicol 1,3-diacetate
-
no activity
-
-
?
acetyl-CoA + D-threo-1-p-nitrophenyl-2-bromoacetamido-1,3-propanediol
CoA + ?
-
-
-
-
?
acetyl-CoA + D-threo-1-p-nitrophenyl-2-bromoacetamido-1,3-propanediol
CoA + ?
-
-
-
-
?
acetyl-CoA + D-threo-1-p-nitrophenyl-2-bromoacetamido-1,3-propanediol
CoA + ?
-
-
-
-
?
acetyl-CoA + D-threo-1-phenyl-2-dichloroacetamido-1,3-propanediol
CoA + ?
-
-
-
-
?
acetyl-CoA + D-threo-1-phenyl-2-dichloroacetamido-1,3-propanediol
CoA + ?
-
-
-
-
?
acetyl-CoA + D-threo-1-phenyl-2-dichloroacetamido-1,3-propanediol
CoA + ?
-
-
-
-
?
additional information
?
-
-
a CAP derivative on sulfidic monolayers on gold chips can still serve as a substrate for the enzyme
-
-
?
additional information
?
-
-
poor substrates: butanol, propanol, ethanol, isopropanol. Specific ester production titers and rates are higher for aromatic alcohols than linear, short-chain alcohols
-
-
-
