2.3.1.74: chalcone synthase

This is an abbreviated version!
For detailed information about chalcone synthase, go to the full flat file.

Reaction

3 malonyl-CoA +

Synonyms

6'-deoxychalcone synthase, anther-specific chalcone synthase-like enzyme, ASCL1, ASCL2, chalcone synthase, chalcone synthase 6, chalcone synthase 7, chalcone synthase C2-Idf-I, chalcone synthase C2-Idf-II, chalcone synthetase, CHS, CHS var 2, chs-1, CHS-7, CHS01, CHS02, CHS03, CHS04, CHS05, CHS06, CHS07, CHS08, CHS088, CHS09, Chs1, CHS10, CHS11, CHS12, CHS13, CHS14, Chs2, CHS2 chalcone synthase, CHS3, CHS4, CHS444, CHS5, CHS6, CHS7, CHS768, CHS_H1, Cs-COR126, DOCS, EC 2.3.1.120, flavanone synthase, flavanone synthetase, GmIRCHS, MdCHS2, More, naringenin-chalcone synthase, naringenin-chalcone synthase 6, PgCHS, PKS1, Q7Y1Y0, RinPKS1, RiPKS4, RiPKS5, synthase, flavanone, vsad1

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.74 chalcone synthase

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Results	in table
17	Activating Compound
1734	AA Sequence
2	Application
1	CAS Registry Number
52	Cloned(Commentary)
5	Crystallization (Commentary)
26	Expression
15	General Information
3	General Stability
56	Inhibitors
26	kcat/KM [mM/s]
2	Ki Value [mM]
62	KM Value [mM]
17	Localization
1	Metals/Ions
32	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
130	Organism
2	Oxidation Stability
10	Pathway
89	PDB ID
21	pH Optimum
31	pI Value
1	Posttranslational Modification
48	Protein Variants
32	Purification (Commentary)
2	Reaction
1	Reaction Type
117	Reference
112	Source Tissue
13	Specific Activity [micromol/min/mg]
10	Storage Stability
193	Substrates and Products (Substrate)
52	Subunits
118	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
3	Temperature Range [°C]
5	Temperature Stability [°C]
28	Turnover Number [1/s]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 2.3.1.74 - chalcone synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

18 entries

3 malonyl-CoA + 4-hydroxycinnamoyl-CoA

4 CoA + naringenin chalcone

Citrus sinensis

-

the enzyme catalyzes the condensation of 4-hydroxycinnamoyl-CoA and three malonyl-CoA molecules to form the chalcone derivative, naringenin chalcone, which is the first committed step in the phenylpropanoid pathway of plants, leading to the biosynthesis of flavonoids, isoflavonoids, and anthocyanins

705629

-

-

?

3 malonyl-CoA + benzoyl-CoA

4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2

Malus domestica

K9MUA0

-

755721

-

-

?

4-coumaroyl-CoA + 3 malonyl-CoA

naringenin chalcone + 4 CoA + 3 CO2

8 entries

caffeoyl-CoA + 3 malonyl-CoA

eriodictyol + 4 CoA + 3 CO2

Xanthisma gracile

-

-

487470

-

487470

?

additional information

?

-

6 entries

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Antirrhinum majus

-

-

757756

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Arabidopsis thaliana

-

-

756665

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Arabidopsis thaliana

P13114

-

757913, 757970

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Arabidopsis thaliana

-

-

757970

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Carthamus tinctorius

A0A1B4XSV2, A0A1B4XSV4, A0A1B4XSV6

-

757784

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Carya illinoinensis

A0A4P9D4C1, A0A4P9D4S8, A0A4P9D6S6

-

756166

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Glycine max

-

-

757756

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Gossypium hirsutum

-

-

756665

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Hypericum perforatum

-

-

756820

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Malus domestica

K9MUA0

-

755721

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Medicago sativa

P30074

-

706814

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Phyllanthus emblica

V5M0E7

-

757489

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Pohlia nutans

A0A482KFN1, A0A482KIB1, A0A482KMM8

-

755796

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Polygonum cuspidatum

H9DV62

-

756731

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Rheum australe

A0A096X8J8, A0A0A0P7Q3

100% activity

758097

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Syringa oblata

-

-

756859

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Vitis vinifera

-

-

706346

-

-

?

3 malonyl-CoA + 4-coumaroyl-CoA

4 CoA + naringenin chalcone + 3 CO2

Zea mays

-

-

756987

-

-

?

4-coumaroyl-CoA + 3 malonyl-CoA

naringenin chalcone + 4 CoA + 3 CO2

Arabidopsis thaliana

-

-

487453

-

-

?

4-coumaroyl-CoA + 3 malonyl-CoA

naringenin chalcone + 4 CoA + 3 CO2

Avena sativa

-

first step in flavonoid biosynthesis in plants

487461

-

487461

?

4-coumaroyl-CoA + 3 malonyl-CoA

naringenin chalcone + 4 CoA + 3 CO2

Daucus carota

-

-

95079, 487463

-

-

?

4-coumaroyl-CoA + 3 malonyl-CoA

naringenin chalcone + 4 CoA + 3 CO2

Fagopyrum esculentum

-

-

487460

-

-

?

4-coumaroyl-CoA + 3 malonyl-CoA

naringenin chalcone + 4 CoA + 3 CO2

Glycyrrhiza echinata

-

key enzyme in flavonoid synthesis

3733

-

-

?

4-coumaroyl-CoA + 3 malonyl-CoA

naringenin chalcone + 4 CoA + 3 CO2

Humulus lupulus

-

key enzyme in prenylflavonoid biosynthesis

672501

-

-

?

4-coumaroyl-CoA + 3 malonyl-CoA

naringenin chalcone + 4 CoA + 3 CO2

Petroselinum crispum

-

-

487467

-

-

?

4-coumaroyl-CoA + 3 malonyl-CoA

naringenin chalcone + 4 CoA + 3 CO2

Xanthisma gracile

-

-

487470

-

-

?

additional information

?

-

Fragaria x ananassa

-

CHS function is an important regulatory point of substrate flow between the flavonoid and the phenylpropanoid pathways

674119

-

-

?

additional information

?

-

Glycine max

Q6X0M8

GmIRCHS is the I gene that inhibits pigmentation over the entire seed coat, resulting in a uniform yellow color of mature harvested seeds

689556

-

-

?

additional information

?

-

Glycine max

-

GmIRCHS is the I gene that inhibits pigmentation over the entire seed coat, resulting in a uniform yellow color of mature harvested seeds

689556

-

-

?

additional information

?

-

Matthiola incana

-

key enzyme of the flavonoid/anthocyanin biosynthesis pathway

663102

-

-

?

additional information

?

-

Phaseolus vulgaris

-

induction of chalcone synthase and phenylalanine ammonia-lyase by salicylic acid and Colletotrichum lindemuthianum

661411

-

-

?

additional information

?

-

Zea mays

-

homozygous C2-Idf plants show no pigmentation. This allele also inhibits expression of functional C2 alleles in heterozygotes, producing a less pigmented condition instead of the normal deeply pigmented phenotype. The inhibitory effect of C2-Idf occurs through RNA silencing

673860

-

-

?