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2.3.2.3: lysyltransferase

This is an abbreviated version!
For detailed information about lysyltransferase, go to the full flat file.

Word Map on EC 2.3.2.3

Reaction

L-lysyl-tRNALys
+
phosphatidylglycerol
=
tRNALys
+
3-O-L-lysyl-1-O-phosphatidylglycerol

Synonyms

LPG synthetase, Lys-tRNA(Lys) phosphatidylglycerol transferase, lysophosphatidylglycerol synthetase, LysX, LysX protein, lysyl-PG synthase, lysyl-transferase-lysyl-tRNA synthetase, lysyltransferase, MprF, MprF flippase, MprF protein, mprF-lysU protein, MprF2, multiple peptide resistance factor protein, phosphatidylglycerol lysyltransferase, phospholipid flippase, RimK-related lysine biosynthesis protein, Rv1640c, Tk0278, TkLysX

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.3 lysyltransferase

Expression

Expression on EC 2.3.2.3 - lysyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
in the presence of AMPs, lysX expression increases significantly. Strains with higher lysX expression show increased levels of intracellular survival in vivo and in vitro and induce more severe lesion related with pneumonia. Comparisons of lysX absolute expression in different strains of Mycobacterium tuberculosis with and without LL-37 (strains H37Rv, H37Ra, Beijing, Beijing4P, MDR, and 5186). Strains H37Rv and Beijing strains similar results are obtained after 30 and 60 min of incubation. H37Ra and Beijing strains do not show differences among stimulation times whereas Beijing, Beijing4P, MDR and 5186 strains showed statistic differences among stimulation times when compared with the respective NoTx condition