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2.4.1.152: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

This is an abbreviated version!
For detailed information about 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.152

Reaction

GDP-beta-L-fucose
+
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R
=
GDP
 +
beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosaminyl-R

Synonyms

11639FucT, alpha (1,3) fucosyltransferase, alpha (1,3)-fucosyltransferase, alpha 1,3 fucosyltransferase, alpha 1,3/4 fucosyltransferase Lewis 2, alpha 3-fucosyltransferase IX, alpha(1,3)-fucosyltransferase VII, alpha(1,3)fucosyltransferase IV, alpha(1,3)fucosyltransferase VII, alpha(1-3)fucosyltransferase, alpha-(1,3)-fucosyltransferase, alpha-(1,3)-fucosyltransferase 11, alpha-(1,3)-fucosyltransferase IXa, alpha-(1,3/1,4)-fucosyltransferase, alpha-(1,3/1,4)-FucT, alpha-1,3 FucT-VII, alpha-1,3-fucosyltransferase, alpha-1,3-fucosyltransferase 3, alpha-1,3-fucosyltransferase 9D, alpha-1,3-fucosyltransferase VI, alpha-1,3-FucT3, alpha-13-fucosyltransferase VII, alpha-3-fucosyltransferase, alpha-3-L-fucosyltransferase, alpha1,3 fucosyltransferase, alpha1,3 fucosyltransferase VII, alpha1,3 FucT-VII, alpha1,3-fucosyltransferase, alpha1,3-fucosyltransferase 4, alpha1,3-fucosyltransferase 9, alpha1,3-fucosyltransferase C, alpha1,3-fucosyltransferase IX, alpha1,3-fucosyltransferase V, alpha1,3-fucosyltransferase VI, alpha1,3-fucosyltransferase-F, alpha1,3-FucT, alpha1,3-FucTIX, alpha1,3/4-fucosyltransferase, alpha1,3/4-fucosyltransferase VI, alpha1,3FT, alpha1,3fucosyltransferase-VII, alpha1-3 fucosyltransferase, alpha1-3 fucosyltransferase-VII, alpha1-3 FucT, alpha1->3fucosyltransferase, alpha3-fucosyltransferase, alpha3-fucosyltransferase IX, alpha3-fucosyltransferase VII, alpha3-fucosyltransferase-V, alpha3-fucosyltransferase-VI, alpha3/4FucT, CEFT-3, CEFT-4, FT-IV, FT-VII, Fuc-Tb, Fuc-TV, Fuc-TXI, fucosyltransferase, fucosyltransferase 11, fucosyltransferase 4, fucosyltransferase 7, fucosyltransferase IV, fucosyltransferase IX, fucosyltransferase V, fucosyltransferase VI, fucosyltransferase VII, fucosyltransferase, guanosine diphosphofucose-glucoside alpha1-->3-, fucosyltransferase-7, fucosyltransferase-VII, fucosyltransferaseIX, FucT, FucT 9, FucT IX, FucT V, FucT-IX, FucT-VI, FucT-VII, FucT-XI, FucT7, FucT9, FucTC, FucTD, FucTe, FucTVII, FUT VI, FuT-F, FUT-VI, FUT10, FUT11, FUT3, FUT4, FUT5, FUT6, FUT7, Fut9, FUT9a, FutA, FutB, galactoside 3-fucosyltransferase, galactoside 3-L-fucosyltransferase 11, GDL-L-fucose:N-acetyl-beta-D-glucosaminyl alpha-3-L-fucosyltransferase, GDP-Fuc:Galbeta1-4GlcNAc (Fuc to GlcNAc) alpha1-3 fucosyltransferase, GDP-fucose:beta-D-N-acetylglucosaminide 3-alpha-fucosyltransferase, GDP-fucose:Galbeta(1-4)GlcNAc-R alpha(1-3)fucosyltransferase, GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-galactosaminyl-R 3-L-fucosyltransferase, guanosine diphosphofucose glucoside alpha1->3fucosyltransferase, HP_0379, HP_0651, Lewis type alpha1,3-FucT, lewis-negative alpha-3-fucosyltransferase, LEwis-type alpha1,3-fucosyltransferase, Lj4g3v0598850, More, plasma alpha-3-fucosyltransferase, PylT, rat fucosyltransferase VII, rFuc-TVII, rFUT7, sFUT9, UA948FucT, WP-000487420, WP-000487428, WP-000487430, XM_016585847, zebrafisha1-3fucosyltrasferase 1, zFT1

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

Disease

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Disease on EC 2.4.1.152 - 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
4-galactosyl-n-acetylglucosaminide 3-alpha-l-fucosyltransferase deficiency
L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest.
Adenocarcinoma of Lung
Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.
Carcinogenesis
Biochemical and biophysical study of chemopreventive and chemotherapeutic anti-tumor potential of some Egyptian plant extracts.
Carcinoma
Core 2 beta1,6-N-acetylglucosaminyltransferases and alpha1,3-fucosyltransferases regulate the synthesis of O-glycans on selectin ligands on oral cavity carcinoma cells.
Parallel changes in the blood levels of abnormally-fucosylated haptoglobin and alpha 1,3 fucosyltransferase in relationship to tumour burden: more evidence for a disturbance of fucose metabolism in cancer.
The use of human milk fucosyltransferase in the synthesis of tumor-associated trimeric X determinants.
Up-regulation of a set of glycosyltransferase genes in human colorectal cancer.
Carcinoma, Hepatocellular
Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.
Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene.
Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells.
Carcinoma, Non-Small-Cell Lung
Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis.
Colonic Neoplasms
Expression and transcriptional regulation of the human alpha1, 3-fucosyltransferase 4 (FUT4) gene in myeloid and colon adenocarcinoma cell lines.
MiR-200c/FUT4 axis prevents the proliferation of colon cancer cells by downregulating the Wnt/?-catenin pathway.
The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.
Colorectal Neoplasms
Alpha1,3 fucosyltransferase VII plays a role in colorectal carcinoma metastases by promoting the carbohydration of glycoprotein CD24.
Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells.
Leukemia
Expression of alpha-(1,3)-fucosyltransferases which synthesize sialyl Le(x) and sialyl Le(a), the carbohydrate ligands for E- and P-selectins,in human malignant cell lines.
Lung Neoplasms
Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis.
Melanoma
A sialyl-Le(x)-negative melanoma cell line binds to E-selectin but not to P-selectin.
Myocarditis
Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart.
Neoplasm Metastasis
Alpha1,3 fucosyltransferase VII plays a role in colorectal carcinoma metastases by promoting the carbohydration of glycoprotein CD24.
Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis.
Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.
L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest.
The use of human milk fucosyltransferase in the synthesis of tumor-associated trimeric X determinants.
Neoplasms
A time-resolved immunofluorometric method for the measurement of sialyl Lewis x-synthesizing alpha1,3-fucosyltransferase activity.
Biochemical and biophysical study of chemopreventive and chemotherapeutic anti-tumor potential of some Egyptian plant extracts.
Expression of alpha-(1,3)-fucosyltransferases which synthesize sialyl Le(x) and sialyl Le(a), the carbohydrate ligands for E- and P-selectins,in human malignant cell lines.
Expressions of Lewis antigens in human non-small cell pulmonary cancer and primary liver cancer with different pathological conditions.
Genomic analysis of the prognostic effect of tumor-associated neutrophil-related genes across 15 solid cancer types: an immune perspective.
Lewis Antigens, alpha1,3 Fucosyltransferses and the Metastatic Potential of Human Primary Liver Cancer.
Parallel changes in the blood levels of abnormally-fucosylated haptoglobin and alpha 1,3 fucosyltransferase in relationship to tumour burden: more evidence for a disturbance of fucose metabolism in cancer.
T-cell trafficking plays an essential role in tumor immunity.
The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.