2.4.1.232: initiation-specific alpha-1,6-mannosyltransferase
This is an abbreviated version!
For detailed information about initiation-specific alpha-1,6-mannosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.232
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2.4.1.232
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mannans
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mannoproteins
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alpha-1,6-linked
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alpha-1,2-mannosidase
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man8glcnac2
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pyridylaminated
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mannoses
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cis-golgi
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man5glcnac2-pp-dol
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polymannose
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drug development
- 2.4.1.232
- mannans
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mannoproteins
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alpha-1,6-linked
- alpha-1,2-mannosidase
- man8glcnac2
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pyridylaminated
- mannoses
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cis-golgi
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man5glcnac2-pp-dol
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polymannose
- drug development
Reaction
Synonyms
AFUA_2G01450, alpha-1,6-mannosyltransferase, alpha-1,6-MT, alpha-mannosyltransferase, alpha1,6-mannosyltransferase KlOch1p, alpha1-6-mannosyltransferase, Anl1p, Anp1p, Dol-P-Man:Man7GlcNAc2-PP-Dol-alpha1-6-mannosyltransferase, GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase, GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase, glycolipid 6-alpha-mannosyltransferase, glycoprotein alpha1-6-mannosyltransferase, HpOCH1, initiation-specific alpha-1,6-mannosyltransferase, mannosyltransferase, guanosine diphosphomannose-glycoprotein alpha1-6-, Mnn9, Mnn9p, och1+, Och1p, ScMnn9p, SpOch1p, TbALG12, VdOCH1, YlOch1p
ECTree
2.4.1.232 initiation-specific alpha-1,6-mannosyltransferaseAdvanced search results
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results (Engineering
Engineering on EC 2.4.1.232 - initiation-specific alpha-1,6-mannosyltransferase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
D236N
site-directed mutagenesis, D236 is the first aspartic acid in the canonical GT-A DxD catalytic motif, and mutation to the isosteric asparagine results in the loss of activity
M16/O16
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chimeric Mnn9p-Och1p protein, a peptide from the first to the 16th amino acids of Mnn9p is fused with a polypeptide from the 16th to the 480th amino acids of Och1p
M33/O37
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chimeric Mnn9p-Och1p protein, a peptide from the first to the 33th amino acids of Mnn9p is fused with a polypeptide from the 37th to the 480th amino acids of Och1p
M93/O80
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chimeric Mnn9p-Och1p protein, a peptide from the first to the 93th amino acids of Mnn9p is fused with a polypeptide from the 80th to the 480th amino acids of Och1p
D236N
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site-directed mutagenesis, D236 is the first aspartic acid in the canonical GT-A DxD catalytic motif, and mutation to the isosteric asparagine results in the loss of activity
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W266stop
inactive mutant strain 7X4 with a nonsense mutation resulting in a truncated Och1p, temperature- and hygromycin B-sensitive, no synthesis of outer chains on acid phosphatase
additional information
additional information
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och1 mutants, och1 mutation causes a complete loss of the alpha-1,6-polymannose outer chain
additional information
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DELTAmnn9 mutant with N-glycosylation defect, null mutant, chimera Mnn9 proteins
additional information
construction of a yeast DELTAMNN9 enzyme deletion strain, presence of inactive full-length ScMnn9 protein partially rescues the DELTAMNN9 phenotype
additional information
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construction of a yeast DELTAMNN9 enzyme deletion strain, presence of inactive full-length ScMnn9 protein partially rescues the DELTAMNN9 phenotype
additional information
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construction of a yeast DELTAMNN9 enzyme deletion strain, presence of inactive full-length ScMnn9 protein partially rescues the DELTAMNN9 phenotype
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additional information
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och1 mutants, och1 mutation causes a complete loss of the alpha-1,6-polymannose outer chain
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additional information
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och1+ gene deficient strain shows loss of mannose transfer from GDP-mannose to Man9GlcNAc2-PA and loss of high-mannose type sugar chain glycosylation, och1 mutant that does not synthesize the outer chains containing mannose on acid phosphatase
additional information
disruption mutant of och1+: viable, slow-growing phenotype, temperature- and hygromycin B-sensitive, no synthesis of outer chains on acid phosphatase
additional information
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disruption mutant of och1+: viable, slow-growing phenotype, temperature- and hygromycin B-sensitive, no synthesis of outer chains on acid phosphatase
additional information
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och1+ gene deficient strain shows loss of mannose transfer from GDP-mannose to Man9GlcNAc2-PA and loss of high-mannose type sugar chain glycosylation, och1 mutant that does not synthesize the outer chains containing mannose on acid phosphatase
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additional information
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OCH1 and Anl1 deletion strains, increased sensitivity to sodium dodecyl sulfate, and to Calcofluor White
