2.4.1.92: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase

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For detailed information about (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylgalactosaminyltransferase, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-ganglioside GM3, beta 1,4-N-acetylgalactosaminyltransferase-A, beta-(1-4)-N-acetylgalactosaminyltransferase, beta-(1->4)-N-acetylgalactosaminyltransferase, beta-1,4 N-acetylgalactosaminyltransferase 1, beta-1,4-N-acetyl-galactosaminyltransferase 1, beta-1,4-N-acetylgalactosaminyl-transferase, beta-1,4-N-acetylgalactosyltransferase II, beta1,4-N-acetylgalactosaminyltransferase, beta4GalNAc-T1, beta4GalNAcT, beta4GalNAcT-I, beta4GalNAcT-II, beta4GalNAcTA, betaGalNAc-T4, CgtA, CJL-30, GA2 synthase, GA2/GM2/GD2/GT2-synthase, GALGT, Galgt1, GalNAcT, ganglioside GM2 synthase, ganglioside GM3 acetylgalactosaminyltransferase, GD2 synthase, GD2 synthetase, GD2/GM2 synthase, GM2 synthase, GM2/GD2 synthase, GM2/GD2-synthase, GM2S, GM3 synthase, GM3S, N-acetylgalactosaminyltransferase I, Sda beta-1,4-N-acetylgalactosaminyltransferase II, ST3Gal V, UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide, UDP-2-acetamido-2-deoxy-D-galactose:(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine acetamidodeoxygalactosyl-transferase, UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosaminyltransferase I, uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide, uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.92 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase

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24	Activating Compound
12	AA Sequence
6	Application
1	CAS Registry Number
8	Cloned(Commentary)
380	Disease/ Diagnostics
4	Expression
13	General Information
2	General Stability
16	Inhibitors
2	Ki Value [mM]
21	KM Value [mM]
18	Localization
32	Metals/Ions
5	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
53	Organism
3	Pathway
8	pH Optimum
1	pH Range
4	Posttranslational Modification
22	Protein Variants
3	Purification (Commentary)
4	Reaction
1	Reaction Type
53	Reference
75	Source Tissue
6	Specific Activity [micromol/min/mg]
4	Storage Stability
80	Substrates and Products (Substrate)
9	Subunits
64	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.4.1.92 - (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase

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SYSTEMATIC NAME

IUBMB Comments

UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase

This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively. Asialo-GM3 [3] and lactosylceramide [2] are also substrates, but glycoproteins and oligosaccharides are not substrates.