2.4.1.92: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylgalactosaminyltransferase, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-ganglioside GM3, beta 1,4-N-acetylgalactosaminyltransferase-A, beta-(1-4)-N-acetylgalactosaminyltransferase, beta-(1->4)-N-acetylgalactosaminyltransferase, beta-1,4 N-acetylgalactosaminyltransferase 1, beta-1,4-N-acetyl-galactosaminyltransferase 1, beta-1,4-N-acetylgalactosaminyl-transferase, beta-1,4-N-acetylgalactosyltransferase II, beta1,4-N-acetylgalactosaminyltransferase, beta4GalNAc-T1, beta4GalNAcT, beta4GalNAcT-I, beta4GalNAcT-II, beta4GalNAcTA, betaGalNAc-T4, CgtA, CJL-30, GA2 synthase, GA2/GM2/GD2/GT2-synthase, GALGT, Galgt1, GalNAcT, ganglioside GM2 synthase, ganglioside GM3 acetylgalactosaminyltransferase, GD2 synthase, GD2 synthetase, GD2/GM2 synthase, GM2 synthase, GM2/GD2 synthase, GM2/GD2-synthase, GM2S, GM3 synthase, GM3S, N-acetylgalactosaminyltransferase I, Sda beta-1,4-N-acetylgalactosaminyltransferase II, ST3Gal V, UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide, UDP-2-acetamido-2-deoxy-D-galactose:(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine acetamidodeoxygalactosyl-transferase, UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosaminyltransferase I, uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide, uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.92 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase

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Results	in table
24	Activating Compound
12	AA Sequence
6	Application
1	CAS Registry Number
8	Cloned(Commentary)
380	Disease/ Diagnostics
4	Expression
13	General Information
2	General Stability
16	Inhibitors
2	Ki Value [mM]
21	KM Value [mM]
18	Localization
32	Metals/Ions
5	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
53	Organism
3	Pathway
8	pH Optimum
1	pH Range
4	Posttranslational Modification
22	Protein Variants
3	Purification (Commentary)
4	Reaction
1	Reaction Type
53	Reference
75	Source Tissue
6	Specific Activity [micromol/min/mg]
4	Storage Stability
80	Substrates and Products (Substrate)
9	Subunits
64	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.4.1.92 - (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

GM3(O-acetyl-(N-glycolyl)neuraminic acid) + UDP-N-acetyl-D-galactosamine

UDP + N-acetyl-D-galactosaminyl-GM3(O-acetyl-(N-glycolyl)neuraminic acid)

Rattus norvegicus

-

less effective substrate

489574

-

-

?

human glycoprotein hormone alpha-subunit + ?

glycosylated human glycoprotein hormone alpha-subunit + ?

Caenorhabditis elegans

-

-

659454

-

-

?

UDP-galactose + p-nitrophenyl-GlcNAc

UDP + Gal-beta(1-4)GlcNAc-p-nitrophenyl

Trichoplusia ni

Q6J4T9

50% of activity with UDP-N-acetylgalactosamine

659370

-

-

?

UDP-GalNAc + 12-azidododecyl 5-(acetylamino)-3,5-dideoxy-beta-L-altro-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside

UDP + 12-azidododecyl 2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-[5-(acetylamino)-3,5-dideoxy-beta-L-altro-non-2-ulopyranonosyl-(2->3)]-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside

Campylobacter jejuni

-

-

703052

-

-

?

UDP-GalNAc + GlcNAcbeta1,3Fuc

UDP + GalNAcbeta1,4GlcNAcbeta1,3Fuc

Drosophila melanogaster

-

DNS-labeled acceptor substrate

671792

-

-

?

UDP-GalNAc + n-octyl-beta-D-glucopyranoside

UDP + GalNAcbeta(1-4)-glc-n-octyl

Mus musculus

-

-

659865

-

-

?

UDP-GalNAc + undec-10-enyl (5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside

UDP + undec-10-enyl (5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->3)-[2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->4)]-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside

Campylobacter jejuni

-

-

703052

-

-

?

UDP-GalNAc + undec-10-yn-1-yl 5-(acetylamino)-3,5-dideoxy-beta-L-altro-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside

UDP + undec-10-yn-1-yl 2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-[5-(acetylamino)-3,5-dideoxy-beta-L-altro-non-2-ulopyranonosyl-(2->3)]-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside

Campylobacter jejuni

-

-

703052

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + ganglioside GD3

UDP + ganglioside GD2

Rattus norvegicus

Q10468

ganglioside GD3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->8)-O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide

746327

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3

UDP + ganglioside GM2

3 entries

UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 amide

UDP + ganglioside GM2 amide

Rattus norvegicus

Q10468

10% of the activity with ganglioside GM3

744829

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 methyl ester

UDP + ganglioside GM2 methyl ester

Rattus norvegicus

Q10468

13% of the activity with ganglioside GM3

744829

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 methylamide

UDP + ganglioside GM2 methylamide

Rattus norvegicus

Q10468

1% of the activity with ganglioside GM3

744829

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + ganglioside lyso-GM3

UDP + ganglioside lyso-GM2

Rattus norvegicus

Q10468

28% of the activity with ganglioside GM3

744829

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + ganglioside N-acetyl-lyso-GM3

UDP + ganglioside N-acetyl-lyso-GM2

Rattus norvegicus

Q10468

160% of the activity with ganglioside GM3

744829

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + ganglioside N-octanoyl-lyso-GM3

UDP + ganglioside N-octanoyl-lyso-GM2

Rattus norvegicus

Q10468

122% of the activity with ganglioside GM3

744829

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + ganglioside N1-pyrenyl-dodecanoyl-lyso-GM3

UDP + ganglioside N1-pyrenyl-dodecanoyl-lyso-GM2

Rattus norvegicus

Q10468

102% of the activity with ganglioside GM3

744829

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + GD3(N-acetylneuraminic acid)-ganglioside

UDP + GD2(N-acetylneuraminic acid)-ganglioside

Mus musculus

-

-

489578

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + GD3(N-glycolylneuraminic acid)-ganglioside

UDP + GD2(N-glycolylneuraminic acid)-ganglioside

Mus musculus

-

-

489578

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + lactosylceramide

UDP-N-acetyl-alpha-D-galactosamine + ganglioside GA2

Rattus norvegicus

Q10468

-

746327

-

-

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

16 entries

UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

?

2 entries

UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

UDP + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

2 entries

UDP-N-acetyl-D-galactosamine + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

?

2 entries

UDP-N-acetyl-D-galactosamine + GD3-ganglioside

UDP + GD2-ganglioside

4 entries

UDP-N-acetyl-D-galactosamine + GM3(N-acetylneuraminic acid)-ganglioside

UDP + GM2(N-acetylneuraminic acid)-ganglioside

2 entries

UDP-N-acetyl-D-galactosamine + GM3(N-glycolylneuraminic acid)-ganglioside

UDP + GM2(N-glycolylneuraminic acid)-ganglioside

3 entries

UDP-N-acetyl-D-galactosamine + lactosylceramide

UDP + GA2-ganglioside

Rattus norvegicus

-

-

489579

-

489579

?

UDP-N-acetyl-D-galactosamine + N-acetylneuraminelactose

UDP + N-acetyl-D-galactosaminyl-N-acetylneuraminelactose

Rattus norvegicus

-

i.e. sialyllactose

489582

-

-

?

UDP-N-acetyl-D-galactosamine + SM3-ganglioside

UDP + SM2-ganglioside

Rattus norvegicus

-

best substrate, no substrates are SM4-ganglioside, Gb3- and Gb4-ceramide

489581

-

-

?

UDP-N-acetylgalactosamine + GlcNAcbeta(1-3)GalNAcalpha-p-nitrophenol (core 3-p-nitrophenol)

UDP + GalNAcbeta(1-4)GlcNAcbeta(1-3)GalNAcalpha-p-nitrophenol

Homo sapiens

Q76KP1

20% of activity compared with N-acetylglucosamine-beta-benzyl

658735

-

-

?

UDP-N-acetylgalactosamine + GlcNAcbeta(1-6)(Galbeta1-3)GalNAcalpha-p-nitrophenol (core 2-p-nitrophenol)

UDP + GalNAcbeta(1-4)GlcNAcbeta(1-6)(Galbeta1-3)GalNAcalpha-p-nitrophenol

Homo sapiens

Q76KP1

15.2% of activity compared with N-acetylglucosamine-beta-benzyl

658735

-

-

?

UDP-N-acetylgalactosamine + GlcNAcbeta(1-6)GalNAcalpha-p-nitrophenol (core 6-p-nitrophenol)

UDP + GalNAcbeta(1-4)GlcNAcbeta(1-6)GalNAcalpha-p-nitrophenol

Homo sapiens

Q76KP1

190.7% of activity compared with N-acetylglucosamine-beta-benzyl

658735

-

-

?

UDP-N-acetylgalactosamine + N-acetylglucosamine-beta-benzyl

N,N'-diacetyllactosediamine + benzol

Homo sapiens

Q76KP1

-

658735

formation of beta-1,4-linkage

-

?

UDP-N-acetylgalactosamine + p-nitrophenyl-GlcNAc

UDP + GalNac-beta(1-4)GlcNAc-p-nitrophenyl

Trichoplusia ni

Q6J4T9

-

659370

-

-

?

UDP-N-acetylglucosamine + p-nitrophenyl-GlcNAc

UDP + GlcNAc-beta(1-4)GlcNAc-p-nitrophenyl

Trichoplusia ni

Q6J4T9

50% of activity with UDP-N-acetylgalactosamine

659370

-

-

?

additional information

?

-

18 entries

UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3

UDP + ganglioside GM2

Homo sapiens

Q00973

-

735601

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3

UDP + ganglioside GM2

Rattus norvegicus

Q10468

ganglioside GM3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide

746327

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3

UDP + ganglioside GM2

Rattus norvegicus

Q10468

ganglioside GM3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramideganglioside

744829

-

-

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Drosophila melanogaster

-

-

673868

-

-

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Homo sapiens

-

-

686976

-

-

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Homo sapiens

-

from human spleen or rat liver

489575

-

-

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Homo sapiens

Q00973

i.e. GM3(N-acetylneuraminic acid), best substrate

489589

-

-

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Homo sapiens

Q00973

relative glycosyltransferase levels involved in determining the ganglioside composition of cells

489588

-

-

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Mus musculus

-

73%-78% as effective as GM3(N-glycolylneuraminic acid)

489578

i.e. GM2(N-acetylneuraminic acid)-ganglioside

489578

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Rattus norvegicus

-

-

489579

i.e. GM2(N-acetylneuraminic acid)-ganglioside

489579

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Rattus norvegicus

-

-

489581

i.e. GM2(N-acetylneuraminic acid)-ganglioside

489581

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Rattus norvegicus

-

-

587166

i.e. GM2(N-acetylneuraminic acid)-ganglioside

587166

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Rattus norvegicus

-

-

587167

i.e. GM2(N-acetylneuraminic acid)-ganglioside

587167

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Rattus norvegicus

-

73%-78% as effective as GM3(N-glycolylneuraminic acid)

489582

i.e. GM2(N-acetylneuraminic acid)-ganglioside

489582

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Rattus norvegicus

-

from human spleen or rat liver

489575

i.e. GM2(N-acetylneuraminic acid)-ganglioside

489575

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Rattus norvegicus

-

less effective: GM3(O-acetyl-(N-glycolyl)neuraminic acid)

489574

i.e. GM2(N-acetylneuraminic acid)-ganglioside

489574

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Rattus norvegicus

-

i.e. GM3(N-acetylneuraminic acid), best substrate

489574

i.e. GM2(N-acetylneuraminic acid)-ganglioside

489574

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Rattus norvegicus

-

model for ganglioside biosynthesis

489579

-

-

?

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

Rattus norvegicus

-

involved in biosynthesis of gangliosides in brain

489574

-

-

?

UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

?

Campylobacter jejuni

-

ganglioside GM3

676275

-

-

?

UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

?

Campylobacter jejuni O:36

-

ganglioside GM3

676275

-

-

?

UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

UDP + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

Campylobacter jejuni

-

-

676275

-

-

?

UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

UDP + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

Campylobacter jejuni O:36

-

-

676275

-

-

?

UDP-N-acetyl-D-galactosamine + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

?

Campylobacter jejuni

-

ganglioside GM2

676275

-

-

?

UDP-N-acetyl-D-galactosamine + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide

?

Campylobacter jejuni O:36

-

ganglioside GM2

676275

-

-

?

UDP-N-acetyl-D-galactosamine + GD3-ganglioside

UDP + GD2-ganglioside

Homo sapiens

-

-

702508

-

-

?

UDP-N-acetyl-D-galactosamine + GD3-ganglioside

UDP + GD2-ganglioside

Homo sapiens

Q00973

-

489589

-

-

?

UDP-N-acetyl-D-galactosamine + GD3-ganglioside

UDP + GD2-ganglioside

Mus musculus

-

GD3(N-glycolylneuraminic acid): 66% as effective as GM3(N-glycolylneuraminic acid), GD3(N-acetylneuraminic acid): 76% as effective as GM3(N-glycolylneuraminic acid)

489578

-

-

?

UDP-N-acetyl-D-galactosamine + GD3-ganglioside

UDP + GD2-ganglioside

Rattus norvegicus

-

-

489579

-

489579

?

UDP-N-acetyl-D-galactosamine + GM3(N-acetylneuraminic acid)-ganglioside

UDP + GM2(N-acetylneuraminic acid)-ganglioside

Mus musculus

-

-

489578

-

-

?

UDP-N-acetyl-D-galactosamine + GM3(N-acetylneuraminic acid)-ganglioside

UDP + GM2(N-acetylneuraminic acid)-ganglioside

Rattus norvegicus

-

-

489582

-

-

?

UDP-N-acetyl-D-galactosamine + GM3(N-glycolylneuraminic acid)-ganglioside

UDP + GM2(N-glycolylneuraminic acid)-ganglioside

Mus musculus

-

best substrate

489578

-

-

?

UDP-N-acetyl-D-galactosamine + GM3(N-glycolylneuraminic acid)-ganglioside

UDP + GM2(N-glycolylneuraminic acid)-ganglioside

Rattus norvegicus

-

best substrate

489582

-

489582

?

UDP-N-acetyl-D-galactosamine + GM3(N-glycolylneuraminic acid)-ganglioside

UDP + GM2(N-glycolylneuraminic acid)-ganglioside

Rattus norvegicus

-

not as effective as GM3(N-acetylneuraminic acid)

489574

-

-

?

additional information

?

-

Caenorhabditis elegans

-

stable expression of enzyme in CHO-Lec8 cells, production of complex-type N-glycans quantitatively bearing LacdiNAc-structures on their antennae and containing repeating LacdiNAc-structures

659454

-

-

?

additional information

?

-

Campylobacter jejuni

-

carbohydrate-protein conjugate enzyme activity with truncated ceramides, analogues of GM3 and GM2 gangliosides, compound sythesis, overview

676275

-

-

?

additional information

?

-

Campylobacter jejuni O:36

-

carbohydrate-protein conjugate enzyme activity with truncated ceramides, analogues of GM3 and GM2 gangliosides, compound sythesis, overview

676275

-

-

?

additional information

?

-

Drosophila melanogaster

-

during evolution, beta4Gal-T1 appears as a result of the single amino acid substitution of Tyr or Phe for Leu or Ile in the invertebrate beta4GalNAc-T1, overview

675421

-

-

?

additional information

?

-

Drosophila melanogaster

-

the enzyme synthesizes the LacdiNAc structures, with GalNAcbeta1,4GlcNAc, on several glycoproteins and glycosphingolipids, including N-glycans, O-glycans, and the arthro-series GSLs, GalNAcbeta1,4Glc-NAcbeta1,3Manbeta1,4Glcbeta1Cer, and neutral GSLs, in vitro and in vivo, the GalNAcbeta1,4GlcNAc, i.e. LacdiNAc or LDN, structure is a more common structural feature in invertebrate glycoconjugates when compared with the Galbeta1,4GlcNAc, i.e. LacNAc or LN, structure

671792

-

-

?

additional information

?

-

Drosophila melanogaster

-

no activity with donor UDP-galactose, the enzyme synthesizes the LacdiNAc structures, with GalNAcbeta1,4GlcNAc, on several glycoproteins and glycosphingolipids, including N-glycans, O-glycans, and the arthro-series GSLs, such as GalNAcbeta1,4Glc-NAcbeta1,3Manbeta1,4Glcbeta1Cer, and neutral GSLs, in vitro and in vivo

671792

-

-

?

additional information

?

-

Drosophila melanogaster

-

the wild-type Drosophila beta4GalNAc-T1 enzyme binds to the mammary gland-specific protein alpha-lactalbumin

675421

-

-

?

additional information

?

-

Homo sapiens

Q00973

overview on substrate specificity

489589

-

-

?

additional information

?

-

Homo sapiens

Q76KP1

enzyme shows similar specificities for O-and N-glykans. Efficiency of transfer decreases as the number of antennas increases

658735

-

-

?

additional information

?

-

Homo sapiens

-

during evolution, beta4Gal-T1 appears as a result of the single amino acid substitution of Tyr or Phe for Leu or Ile in the invertebrate beta4GalNAc-T1, overview

675421

-

-

?

additional information

?

-

Mus musculus

-

no substrate: lactosylceramide, sialylparagloboside, GM1b(N-glycolylneuraminic acid), GD1a(N-acetylneuraminic acid), GT1b(N-acetylneuraminic acid), GQ1b(N-acetylneuraminic acid), GM1a(N-acetylneuraminic acid), GD1b(N-acetylneuraminic acid), globoside

489578

-

-

?

additional information

?

-

Mus musculus

-

poor substrate: sialyllactose

489578

-

-

?

additional information

?

-

Rattus norvegicus

-

acceptor specificity

587166

-

-

?

additional information

?

-

Rattus norvegicus

-

poor substrate: GM2-, GM1-, GD1b- and GT1-gangliosides and various ceramides

489574

-

-

?

additional information

?

-

Rattus norvegicus

-

no substrate: N-acetylglucosamine

489574

-

-

?

additional information

?

-

Rattus norvegicus

-

no substrates are SM4-ganglioside, Gb3- and Gb4-ceramide

489581

-

-

?

additional information

?

-

Rattus norvegicus

-

no substrate: blood type H glycoprotein, deglucosylated bovine submaxillary mucin, various ceramides

489582

-

-

?

additional information

?

-

Trichoplusia ni

Q6J4T9

no in vitro transfer of substrates other than UDP-N-acetylgalactosamine to synthetic N-glycans

659370

-

-

?