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2.5.1.111: 4-hydroxyphenylpyruvate 3-dimethylallyltransferase

This is an abbreviated version!
For detailed information about 4-hydroxyphenylpyruvate 3-dimethylallyltransferase, go to the full flat file.

Word Map on EC 2.5.1.111

Reaction

dimethylallyl diphosphate
+
4-hydroxyphenylpyruvate
=
diphosphate
 +
3-dimethylallyl-4-hydroxyphenylpyruvate

Synonyms

4HPP dimethylallyltransferase, apT, aromatic prenyltransferase, CloQ, FamD1, isoprenyl transferase, NovQ

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.111 4-hydroxyphenylpyruvate 3-dimethylallyltransferase

Engineering

Engineering on EC 2.5.1.111 - 4-hydroxyphenylpyruvate 3-dimethylallyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E281A
the mutant shows about 10% activity compared to the wild type enzyme
E281D
the mutant shows about 78% activity compared to the wild type enzyme
E281K
the mutant shows about 60% activity compared to the wild type enzyme
E281M
the mutant shows about 98% activity compared to the wild type enzyme
E281Q
the mutant shows 205% activity compared to the wild type enzyme
E281R
the mutant shows about 5% activity compared to the wild type enzyme
E281S
the mutant shows about 30% activity compared to the wild type enzyme
E281T
the mutant shows about 40% activity compared to the wild type enzyme
E281V
the mutant shows about 78% activity compared to the wild type enzyme
E281A
Streptomyces niveus CPCC 240348
-
the mutant shows about 10% activity compared to the wild type enzyme
-
E281D
Streptomyces niveus CPCC 240348
-
the mutant shows about 78% activity compared to the wild type enzyme
-
E281K
Streptomyces niveus CPCC 240348
-
the mutant shows about 60% activity compared to the wild type enzyme
-
E281Q
Streptomyces niveus CPCC 240348
-
the mutant shows 205% activity compared to the wild type enzyme
-
E281R
Streptomyces niveus CPCC 240348
-
the mutant shows about 5% activity compared to the wild type enzyme
-
C215A
activity is comparable to that of the wild-type enzyme
C215S
activity is comparable to that of the wild-type enzyme
E281G
F68S
molecular dynamics simulations
R160A
mutant enzyme shows 17.3% of wild-type activity
R160Q
mutant enzyme shows 19.7% of wild-type activity
R66S
mutant enzyme shows 1.9% of wild-type activity