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evolution
structures of catalytic cycle intermediates of the Pyrococcus furiosus methionine adenosyltransferase demonstrate negative cooperativity in the archaeal orthologues. The distinct molecular mechanism for S-adenosylmethionine synthesis in Archaea is likely consequence of the evolutionary pressure to achieve protein stability under extreme conditions
evolution
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structures of catalytic cycle intermediates of the Pyrococcus furiosus methionine adenosyltransferase demonstrate negative cooperativity in the archaeal orthologues. The distinct molecular mechanism for S-adenosylmethionine synthesis in Archaea is likely consequence of the evolutionary pressure to achieve protein stability under extreme conditions
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malfunction
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addition of the methionine adenosyltransferase (MAT2A) inhibitor FIDAS to the culture media of bovine preimplantation embryos reduces their blastocyst development
malfunction
depletion of S-adenosylmethionine has downstream effects on polyamine metabolism and methylation reactions, and is an effective way to combat pathogenic microorganisms such as malaria parasites
malfunction
knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo
malfunction
knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo
malfunction
mat3 mutants have impaired pollen tube growth and reduced seed set. Metabolomics analyses confirms that mat3 pollen and pollen tubes overaccumulate Met and that mat3 pollen has several metabolite profiles, such as those of polyamine biosynthesis, which are different from those of the wild type. Disruption of Met metabolism in mat3 pollen affects transfer RNA and histone methylation levels
malfunction
mat4 mostly decreases CHG and CHH DNA methylation and histone H3K9me2 and reactivates certain silenced transposons. The exogenous addition of S-adenosyl-L-methionine partially rescues the epigenetic defects of mat4. MAT4 knockout mutations generated by CRISPR/Cas9 are lethal, indicating that MAT4 is an essential gene in Arabidopsis
malfunction
sam1 mutants lose viability during nitrogen starvation-induced G0 phase quiescence. After release from the G0 state, sam1 mutants could neither increase in cell size nor re-initiate DNA replication in the rich medium
malfunction
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sam1 mutants lose viability during nitrogen starvation-induced G0 phase quiescence. After release from the G0 state, sam1 mutants could neither increase in cell size nor re-initiate DNA replication in the rich medium
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metabolism
the enzyme plays a key role in the biogenesis of S-adenosyl-L-methionine
metabolism
as a methyl group donor for biochemical reactions, the product S-adenosylmethionine plays a central metabolic role in most organisms
metabolism
methionine adenosyltransferase IIalpha (MAT IIalpha) is a key enzyme in methionine metabolism and is associated with uncontrolled cell proliferation in cancer
metabolism
S-adenosyl-L-methionine (AdoMet) is the primary methyl donor in most biological methylation reactions, is produced from ATP and methionine in a multistep reaction catalyzed by AdoMet synthetase. The diversity of group transfer reactions that involve AdoMet places this compound at a key crossroads in amino-acid, nucleic acid and lipid metabolism
metabolism
the enzyme catalyse the biosynthesis of S-adenosylmethionine, the primary methyl group donor in biochemical reactions
metabolism
the enzyme catalyzes the synthesis of S-adenosyl-Met in the one-carbon metabolism cycle. MAT4 plays a predominant role in SAM production, plant growth, and development
metabolism
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the enzyme is involved in folate-mediated one-carbon metabolism which is essential for preimplantation embryos in terms of both short-term periconceptional development and long-term phenotypic programming beyond the periconceptional period. Particular importance of the enzyme (MAT2A) in successful blastocyst development. Critical involvement of the enzyme (MAT2A) in the periconceptional period in life-long programming of health and disease as well as successful preimplantation development
metabolism
the enzyme is involved in S-adenosylmethionine synthesis in liver. MATalpha1 interacts mainly with Mnt in normal liver but this switches to c-Maf, MafG and c-Myc in cholestatic livers and cholangiocarcinoma. Knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo
metabolism
the enzyme is involved in S-adenosylmethionine synthesis in liver. MATalpha1 interacts mainly with Mnt in normal liver but this switches to c-Maf, MafG and c-Myc in cholestatic livers and cholangiocarcinoma. Knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo
metabolism
the product S-adenosyl-L-methionine plays important roles in trans-methylation, transsulfuration, and polyamine synthesis in all living cells
metabolism
the product S-adenosylmethionine serves as the methyl donor in most methyl transfer reactions, including methylation of proteins, nucleic acids, and lipids. The enzyme is required for cell growth and proliferation, and maintenance of and exit from quiescence
metabolism
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the product S-adenosyl-L-methionine plays important roles in trans-methylation, transsulfuration, and polyamine synthesis in all living cells
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metabolism
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the product S-adenosylmethionine serves as the methyl donor in most methyl transfer reactions, including methylation of proteins, nucleic acids, and lipids. The enzyme is required for cell growth and proliferation, and maintenance of and exit from quiescence
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metabolism
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the enzyme catalyse the biosynthesis of S-adenosylmethionine, the primary methyl group donor in biochemical reactions
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metabolism
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S-adenosyl-L-methionine (AdoMet) is the primary methyl donor in most biological methylation reactions, is produced from ATP and methionine in a multistep reaction catalyzed by AdoMet synthetase. The diversity of group transfer reactions that involve AdoMet places this compound at a key crossroads in amino-acid, nucleic acid and lipid metabolism
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physiological function
doxorubicin production by the metK1-sp-deleted mutant is reduced
physiological function
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MAT2A or MAT2beta silencing results in decreased collagen and alpha-smooth muscle actin expression and cell growth and increased apoptosis. MAT2A knockdown decreases intracellular S-adenosylmethionine levels in LX-2 cells. Activation of extracellular signal-regulated kinase and phosphatidylinositol-3-kinase signaling in LX-2 cells requires the expression of MAT2 but not that of MAT2A
physiological function
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MAT2A silencing in primary heaptic stellate cells results in decreased collagen and alpha-smooth muscle actin expression and cell growth and increased apoptosis
physiological function
the enzyme is involved in biosynthesis of S-adenosyl-L-methionine
physiological function
enzyme overexpression is positively correlated with polyamine and hydrogen peroxide accumulation leading to improve alkali stress tolerance
physiological function
enzyme overexpression promotes polyamine synthesis and oxidation, which in turn improves H2O2-induced antioxidant protection, as a result enhances tolerance to freezing and chilling stress in transgenic plants
physiological function
transgenic tomato plants overexpressing SAMS1 exhibit a significant increase in tolerance to alkali stress and maintained nutrient balance, higher photosynthetic capacity and lower oxidative stress compared with wild type lines
physiological function
methionine adenosyltransferase IIalpha (MAT IIalpha) is a key enzyme in methionine metabolism and is associated with uncontrolled cell proliferation in cancer
physiological function
S-adenosylmethionine synthetase 3 is important for pollen tube growth
physiological function
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the enzyme is involved in the mechanism of cold tolerance by controlling plant cell wall thickness
physiological function
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the enzyme is involved in biosynthesis of S-adenosyl-L-methionine
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physiological function
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the enzyme is involved in the mechanism of cold tolerance by controlling plant cell wall thickness
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