2.5.1.87: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]

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Reaction

Synonyms

AcpT, anther-66, cis-prenyltransferase, cis-PTase, CPT1, Dedol-PP synthase, DedolPP synthase, dehydrodolichyl diphosphate synthase, dehydrodolichyl diphosphate synthase 1, DHDDS, NgBR, Nogo-B receptor, RER2, Rer2p, Rer2p Z-prenyltransferase, SlCPT3, SRT1, Srt1p, Srt2p Z-prenyltransferase, Tk-IdsB

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]

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Results	in table
2	Activating Compound
3232	AA Sequence
15	Cloned(Commentary)
1	Crystallization (Commentary)
170	Disease/ Diagnostics
5	Expression
23	General Information
2	Inhibitors
13	KM Value [mM]
19	Localization
7	Metals/Ions
6	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
26	Organism
5	Pathway
18	PDB ID
6	pH Optimum
2	pI Value
11	Protein Variants
2	Purification (Commentary)
1	Reaction
24	Reference
16	Source Tissue
2	Storage Stability
30	Substrates and Products (Substrate)
5	Subunits
47	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Temperature Stability [°C]

Crystallization

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Crystallization on EC 2.5.1.87 - ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

on the basis of Escherichia coli undecaprenyl diphosphate synthase crystallographic structure the yeast Rer2p model is constructed. In the model three amino acid residues inserted into the sequence corresponding to the floor region of the tunnel extends the bottom loop what results in the required increase of the tunnel volume. Thermal fluctuations of this loop occasionally create a hole in the tunnel floor, making escape of polyprenol omega end out of the tunnel possible what switches off the control mechanism of product length thereby allowing a practically unlimited elongation process leading to an exponential distribution of longer chain polyprenols

Saccharomyces cerevisiae

P35196, Q03175

702710