2.6.1.75: cysteine-conjugate transaminase
This is an abbreviated version!
For detailed information about cysteine-conjugate transaminase, go to the full flat file.
Reaction
Synonyms
aminotransferase, cysteine conjugate, cysteine-conjugate alpha-ketoglutarate transaminase
ECTree
2.6.1.75 cysteine-conjugate transaminaseAdvanced search results
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Substrates Products on EC 2.6.1.75 - cysteine-conjugate transaminase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-aspartic acid + 2-oxoglutarate
oxaloacetate + L-glutamate
-
reactivity of isozymes: less than 5% for CAT-I, 15% for CAT-IIA, 42% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine
-
-
?
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionate + L-glutamate
-
reactivity of isozymes: less than 5% for CAT-I, 7% for CAT-IIA, 76% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine
-
-
?
L-kynurenine + 2-oxoglutarate
L-glutamate + 4-(2-aminophenyl)-2,4-dioxobutanoate
-
reactivity of isozymes: 7% for CAT-I, 6% for CAT-IIA, 12% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine
-
-
?
S-(1-butyl)-L-cysteine + 2-oxoglutarate
S-(1-butyl)-3-thiopyruvate + L-glutamate
-
reactivity of isozymes: 23% for CAT-I, 30% for CAT-IIA, 33% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine
-
-
?
S-(1-propyl)-L-cysteine + 2-oxoglutarate
S-(1-propyl)-3-thiopyruvate + L-glutamate
-
reactivity of isozymes: 16% for CAT-I, 13% for CAT-IIA, 14% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine
-
-
?
S-(4-bromophenyl)-L-cysteine + 2-oxoglutarate
S-(4-bromophenyl)-3-thiopyruvate + L-glutamate
-
highest activity with all three isoenzymes: CAT-I, CAT-IIA, CAT-IIB
-
r
S-(4-bromophenyl)-L-cysteine + 4-methylsulfanyl-2-oxobutanoate
S-(4-bromophenyl)-3-thiopyruvate + methionine
-
21% of activity compared to 2-oxoglutarate
-
-
?
S-benzyl-L-cysteine + 2-oxoglutarate
S-benzyl-3-thiopyruvate + L-glutamate
-
reactivity of isozymes: 19% for CAT-I, 16% for CAT-IIA, 20% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine
-
-
?
S-phenyl-L-cysteine + 2-oxoglutarate
S-phenyl-3-thiopyruvate + L-glutamate
-
reactivity of isozymes: 36% for CAT-I, 24% for CAT-IIA, 34% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine
-
-
?
additional information
?
-
-
2-oxobutanoate, 2-oxosuccinate and pyruvate exhibit about 3% of activity compared to alpha-ketoglutarate
-
-
?
additional information
?
-
-
glyoxylic acid, S-ethyl-L-cysteine, S-2-propyl-L-cysteine, S-cyclohexyl-L-cysteine, S-(2-chloroethyl)-L-cysteine, S-phenyl-L-cysteine sulfoxide are not substrates, negligible activity with other amino acids e.g. L-leucine, L-configuration is essential
-
-
?
additional information
?
-
-
isoenzyme CAT-I may be involved in in vivo transamination of cysteine conjugates in rat liver, value of reverse reaction is 5 times lower than forward reaction by CAT-I, forward and reverse reaction at similar rates for CAT-IIA and CAT-IIB
-
-
?
