2.7.1.113: deoxyguanosine kinase

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For detailed information about deoxyguanosine kinase, go to the full flat file.

Reaction

Synonyms

(dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, deoxyadenosine kinase/deoxyguanosine kinase, deoxyguanosine kinase, DG kinase, DGK, dGKase, DGUOK, kinase, deoxyguanosine (phosphorylating), NTP-deoxyguanosine 5'-phosphotransferase, nucleoside triphosphate: deoxyguanosine 5'-phosphotransferase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.113 deoxyguanosine kinase

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Results	in table
15	Activating Compound
771	AA Sequence
2	Application
1	CAS Registry Number
14	Cloned(Commentary)
33	Cofactor
2	Crystallization (Commentary)
334	Disease/ Diagnostics
2	Expression
9	General Information
9	General Stability
95	Inhibitors
5	kcat/KM [mM/s]
36	Ki Value [mM]
99	KM Value [mM]
32	Localization
47	Metals/Ions
13	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
59	Organism
5	Pathway
18	PDB ID
15	pH Optimum
5	pH Range
3	pH Stability
2	pI Value
42	Protein Variants
9	Purification (Commentary)
5	Reaction
1	Reaction Type
54	Reference
69	Source Tissue
19	Specific Activity [micromol/min/mg]
6	Storage Stability
175	Substrates and Products (Substrate)
8	Subunits
43	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
23	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 2.7.1.113 - deoxyguanosine kinase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

CTP

Homo sapiens

-

activation, with ATP as substrate at pH 7

640553

dCDP

Bos taurus

-

slight stimulation, with ATP as substrate

640550

dTDP

Bos taurus

-

1 mM, 620% activation of mitochondrial deoxyguanosine kinase, positive modulation with ATP as substrate

640550

dTTP

2 entries

dUTP

Homo sapiens

-

activation, with ATP as substrate, at pH 7

640553

Sodium diphosphate

Bos taurus

-

1 mM, 120% stimulation of mitochondrial deoxyguanosine kinase

640550

Triton X-100

2 entries

UDP

Bos taurus

-

1 mM, 310% activation of mitochondrial deoxyguanosine kinase, with ATP as substrate

640550

UTP

3 entries

additional information

2 entries

-

dTTP

Bos taurus

-

1 mM, 280% activation of mitochondrial deoxyguanosine kinase

640550

dTTP

Homo sapiens

-

1 mM, 3-4fold activation of deoxyguanosine kinase at pH 7.0

640553

Triton X-100

Bos taurus

-

maximal activation at concentrations above critical micelle concentration

640551

Triton X-100

Homo sapiens

Q16854

-

661453

UTP

Bos taurus

-

1 mM, 190% activation of mitochondrial deoxyguanosine kinase

640550

UTP

Homo sapiens

-

slight inhibition at pH 6

640553

UTP

Homo sapiens

-

stimulation with ATP as substrate, at pH 7

640553

additional information

Bos taurus

-

not activated by dCTP or dATP, with ATP as substrate

640550

-

additional information

Homo sapiens

-

not activated by dTDP

640553

-