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York, J.D.; Odom, A.R.; Murphy, R.; Ives, E.B.; Wente, S.R.
A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export
Science
285
96-100
1999
Saccharomyces cerevisiae
brenda
Ongusaga, P.P.; Hughes, P.J.; Davey, J.; Michell, R.H.
Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation
Biochem. J.
335
671-679
1998
Schizosaccharomyces pombe
-
brenda
Sweetman, D.; Johnson, S.; Caddick, S.E.; Hanke, D.E.; Brearley, C.A.
Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1)
Biochem. J.
394
95-103
2006
Arabidopsis thaliana
brenda
Phillippy, B.Q.; Ullah, A.H.J.; Ehrlich, K.C.
Purification and some properties of inositol 1,3,4,5,6-pentakis phosphate 2-kinase from immature soybean seeds
J. Biol. Chem.
269
28393-28399
1994
Glycine max
brenda
Ives, E.B.; Nichols, J.; Wente, S.R.; York, J.D.
Biochemical and functional characterization of inositol 1,3,4,5,6-pentakisphosphate 2-kinases
J. Biol. Chem.
275
36575-36583
2000
Saccharomyces cerevisiae, Schizosaccharomyces pombe (Q9USK0), Schizosaccharomyces pombe
brenda
Verbsky, J.W.; Wilson, M.P.; Kisseleva, M.V.; Majerus, P.W.; Wente, S.R.
The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase
J. Biol. Chem.
277
31857-31862
2002
Homo sapiens
brenda
Miller, A.L.; Suntharalingam, N.; et al.
Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway
J. Biol. Chem.
279
51022-51032
2004
Saccharomyces cerevisiae
brenda
Fujii, M.; York, J.D.
A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells
J. Biol. Chem.
280
1156-1164
2005
Rattus norvegicus, Rattus norvegicus (Q5PXE9)
brenda
Verbsky, J.; Lavine, K.; Majerus, P.W.
Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression
Proc. Natl. Acad. Sci. USA
102
8448-8453
2005
Mus musculus
brenda
Brehm, M.A.; Schenk, T.M.; Zhou, X.; Fanick, W.; Lin, H.; Windhorst, S.; Nalaskowski, M.M.; Kobras, M.; Shears, S.B.; Mayr, G.W.
Intracellular localization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Biochem. J.
408
335-345
2007
Homo sapiens
brenda
Sun, Y.; Thompson, M.; Lin, G.; Butler, H.; Gao, Z.; Thornburgh, S.; Yau, K.; Smith, D.A.; Shukla, V.K.
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase from maize: molecular and biochemical characterization
Plant Physiol.
144
1278-1291
2007
Zea mays, Zea mays (A4GWX8), Zea mays (A6YH13)
brenda
Caddick, S.E.; Harrison, C.J.; Stavridou, I.; Mitchell, J.L.; Hemmings, A.M.; Brearley, C.A.
A Solanum tuberosum inositol phosphate kinase (StITPK1) displaying inositol phosphate-inositol phosphate and inositol phosphate-ADP phosphotransferase activities
FEBS Lett.
582
1731-1737
2008
Solanum tuberosum (A4H2J0), Solanum tuberosum
brenda
Sarmah, B.; Wente, S.R.
Dual functions for the Schizosaccharomyces pombe inositol kinase Ipk1 in nuclear mRNA export and polarized cell growth
Eukaryot. Cell
8
134-146
2009
Schizosaccharomyces pombe (Q9USK0), Schizosaccharomyces pombe
brenda
Poehlmann, J.; Fleig, U.
Asp1, a conserved 1/3 inositol polyphosphate kinase, regulates the dimorphic switch in Schizosaccharomyces pombe
Mol. Cell. Biol.
30
4535-4547
2010
Schizosaccharomyces pombe
brenda
Wundenberg, T.; Grabinski, N.; Lin, H.; Mayr, G.W.
Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio
Biochem. J.
462
173-184
2014
Homo sapiens, Rattus norvegicus
brenda
Chanduri, M.; Rai, A.; Malla, A.B.; Wu, M.; Fiedler, D.; Mallik, R.; Bhandari, R.
Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport
Biochem. J.
473
3031-3047
2016
Mus musculus (Q6PD10)
brenda
Wang, H.; Godage, H.Y.; Riley, A.M.; Weaver, J.D.; Shears, S.B.; Potter, B.V.
Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery
Chem. Biol.
21
689-699
2014
Homo sapiens
brenda
Gosein, V.; Miller, G.J.
Roles of phosphate recognition in inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) substrate binding and activation
J. Biol. Chem.
288
26908-26913
2013
Arabidopsis thaliana (Q93YN9)
brenda
Gosein, V.; Miller, G.J.
Conformational stability of inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) dictates its substrate selectivity
J. Biol. Chem.
288
36788-36795
2013
Arabidopsis thaliana
brenda
Brehm, M.; Wundenberg, T.; Williams, J.; Mayr, G.; Shears, S.
A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA
J. Cell Sci.
126
437-444
2013
Homo sapiens
-
brenda
Sun, Y.Y.; Xu, W.Z.; Wu, L.; Wang, R.Z.; He, Z.Y.; Ma, M.
An Arabidopsis mutant of inositol pentakisphosphate 2-kinase AtIPK1 displays reduced arsenate tolerance
Plant Cell Environ.
39
416-426
2016
Arabidopsis thaliana (Q93YN9), Arabidopsis thaliana
brenda
Kuo, H.F.; Chang, T.Y.; Chiang, S.F.; Wang, W.D.; Charng, Y.Y.; Chiou, T.J.
Arabidopsis inositol pentakisphosphate 2-kinase, AtIPK1, is required for growth and modulates phosphate homeostasis at the transcriptional level
Plant J.
80
503-515
2014
Arabidopsis thaliana (Q93YN9)
brenda
Yu, J.; Saiardi, A.; Greenwood, J.S.; Bewley, J.D.
Molecular and biochemical identification of inositol 1,3,4,5,6-pentakisphosphate 2-kinase encoding mRNA variants in castor bean (Ricinus communis L.) seeds
Planta
239
965-977
2014
Ricinus communis
brenda
Basak, N.; Krishnan, V.; Pandey, V.; Punjabi, M.; Hada, A.; Marathe, A.; Jolly, M.; Palaka, B.K.; Ampasala, D.R.; Sachdev, A.
Expression profiling and in silico homology modeling of inositol pentakisphosphate 2-kinase, a potential candidate gene for low phytate trait in soybean
3 Biotech
10
268
2020
Glycine max (I1JT87), Glycine max (U5TRK1), Glycine max
brenda
Looker, H.C.; Merchant, M.L.; Rane, M.J.; Nelson, R.G.; Kimmel, P.L.; Rovin, B.H.; Klein, J.B.; Mauer, M.; Mauer, M.
Urine inositol pentakisphosphate 2-kinase and changes in kidney structure in early diabetic kidney disease in type 1 diabetes
Am. J. Physiol. Renal Physiol.
315
F1484-F1492
2018
Homo sapiens (Q9H8X2), Homo sapiens
brenda
Whitfield, H.; White, G.; Sprigg, C.; Riley, A.M.; Potter, B.V.L.; Hemmings, A.M.; Brearley, C.A.
An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels
Biochem. J.
477
2621-2638
2020
Arabidopsis thaliana (Q93YN9)
brenda
Basak, N.; Krishnan, V.; Pandey, V.; Punjabi, M.; Hada, A.; Marathe, A.; Jolly, M.; Sachdev, A.
Molecular characterization of inositol pentakisphosphate 2-kinase (GmlPk1) from soybean and its expression pattern in the developing seeds
Indian J. Genet. Plant Breed.
77
371-378
2017
Glycine max (U5TRK1)
-
brenda
Franco-Echevarria, E.; Sanz-Aparicio, J.; Brearley, C.A.; Gonzalez-Rubio, J.M.; Gonzalez, B.
The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function
J. Biol. Chem.
292
10534-10548
2017
Mus musculus (Q6P1C1), Mus musculus
brenda
Whitfield, H.; Gilmartin, M.; Baker, K.; Riley, A.M.; Godage, H.Y.; Potter, B.V.L.; Hemmings, A.M.; Brearley, C.A.
A fluorescent probe identifies active site ligands of inositol pentakisphosphate 2-kinase
J. Med. Chem.
61
8838-8846
2018
Arabidopsis thaliana (Q93YN9)
brenda
Oh, J.; Lee, D.G.; Bahn, Y.S.; Rhee, S.
Crystal structure of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from Cryptococcus neoformans
J. Struct. Biol.
200
118-123
2017
Cryptococcus neoformans var. grubii (J9VKS8), Cryptococcus neoformans var. grubii FGSC 9487 (J9VKS8), Cryptococcus neoformans var. grubii ATCC 208821 (J9VKS8), Cryptococcus neoformans var. grubii CBS 10515 (J9VKS8)
brenda
Kuo, H.; Hsu, Y.; Lin, W.; Chen, K.; Munnik, T.; Brearley, C.; Chiou, T.
Arabidopsis inositol phosphate kinases IPK1 and ITPK1 constitute a metabolic pathway in maintaining phosphate homeostasis
Plant J.
95
613-630
2018
Arabidopsis thaliana (Q93YN9), Arabidopsis thaliana
brenda
Franco-Echevarria, E.; Sanz-Aparicio, J.; Troffer-Charlier, N.; Poterszman, A.; Gonzalez, B.
Crystallization and preliminary X-ray diffraction analysis of a mammal inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Protein J.
36
240-248
2017
Mus musculus (Q6P1C1), Mus musculus
brenda