2.7.1.45: 2-dehydro-3-deoxygluconokinase
This is an abbreviated version!
For detailed information about 2-dehydro-3-deoxygluconokinase, go to the full flat file.
Word Map on EC 2.7.1.45
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2.7.1.45
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sulfolobus
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entner-doudoroff
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archaeon
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thermus
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solfataricus
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non-phosphorylative
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aldolase
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hyperthermophilic
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2-keto-3-deoxy-6-phosphogluconate
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thermoacidophilic
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haloferax
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volcanii
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2-keto-d-gluconate
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fructosamine
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nonphosphorylated
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galacturonate
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alginate
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6-kinase
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haloarchaeon
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thermotoga
- 2.7.1.45
- sulfolobus
-
entner-doudoroff
- archaeon
- thermus
- solfataricus
-
non-phosphorylative
- aldolase
-
hyperthermophilic
- 2-keto-3-deoxy-6-phosphogluconate
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thermoacidophilic
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haloferax
- volcanii
- 2-keto-d-gluconate
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fructosamine
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nonphosphorylated
- galacturonate
- alginate
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6-kinase
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haloarchaeon
- thermotoga
Reaction
Synonyms
2-dehydrogluconokinase, 2-keto-3-deoxy-D-gluconate kinase, 2-keto-3-deoxy-D-gluconic acid kinase, 2-keto-3-deoxygluconate kinase, 2-keto-3-deoxygluconokinase, 2-ketogluconate kinase, FlKin, HVO_0549, KDG kinase, KDGK, KDGK-1, ketodeoxygluconokinase, KGUK, KGUKCnec, kinase, 2-keto-3-deoxyglucono- (phosphorylating), More, Ta0122, TM0067
ECTree
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Reaction
Reaction on EC 2.7.1.45 - 2-dehydro-3-deoxygluconokinase
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ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate
active site structure, substrate binding structure involving amino acid residues L11, G34, A35, N38, Y89, Y103, R105, I134, R167, V247, E251, and E287, 2-dehydro-3-deoxy-D-gluconate is recognized as an open chain structure, catalytic mechanism, Arg167 and Asp251 play a role in transferring the gamma-phosphate of ATP to the 5'-hydroxyl group of 2-dehydro-3-deoxy-D-gluconate
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ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate
reaction is initiated by the deprotonation of the hydroxyl group of the substrate by the catalytic base Asp280. A nucleophilic attack on the gamma-phosphate of ATP by the negatively charged hydroxyl group generates the transition state intermediate
ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate
active site structure, substrate binding structure involving amino acid residues L11, G34, A35, N38, Y89, Y103, R105, I134, R167, V247, E251, and E287, 2-dehydro-3-deoxy-D-gluconate is recognized as an open chain structure, catalytic mechanism, Arg167 and Asp251 play a role in transferring the gamma-phosphate of ATP to the 5'-hydroxyl group of 2-dehydro-3-deoxy-D-gluconate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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