2.7.2.2: carbamate kinase
This is an abbreviated version!
For detailed information about carbamate kinase, go to the full flat file.
Word Map on EC 2.7.2.2
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2.7.2.2
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ornithine
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deiminase
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dihydrolase
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citrulline
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transcarbamoylase
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carbamyltransferase
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arcabc
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n-acetyl-l-glutamate
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drug development
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degradation
- 2.7.2.2
- ornithine
- deiminase
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dihydrolase
- citrulline
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transcarbamoylase
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carbamyltransferase
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arcabc
- n-acetyl-l-glutamate
- drug development
- degradation
Reaction
Synonyms
ACK, anabolic carbamyl kinase, ArcC, carbamate kinase, carbamoyl phosphokinase, carbamyl phosphokinase, catabolic carbamyl kinase, Cbk, CCK, CK, CK-like CPS, CKase, GlcK, kinase, carbamate (phosphorylating), putrescine synthase
ECTree
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Inhibitors
Inhibitors on EC 2.7.2.2 - carbamate kinase
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2,3-Butanedione
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in borate buffer, inactivation, implying the presence of an essential arginine
Disulfiram
the anti-alcoholism drug kills the trophozoites and inhibits the enzyme. Disulfiram acts by modifying Cys-242 adjacent to the active site and cures giardiasis in mice. The compound thiocarbamoylates Cys242, a residue located at the edge of the active site. The modified Cys242 prevents a conformational transition of a loop adjacent to the ADP/ATP binding site, which is required for the stacking of Tyr245 side chain against the adenine moiety
metronidazole
irreversible inactivation mechanism, the thiuram compounds can circumvent the resistance mechanism that renders metronidazole ineffectiveness in drug resistance cases of giardiasis
not inhibitory: adenosine(5')triphospho(5')adenosine, phosphate, phosphonoformate
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additional information
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not inhibitory: adenosine(5')triphospho(5')adenosine, phosphate, phosphonoformate
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additional information
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N-acetyl-L-glutamate and L-glutamine have no influence on activity
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