2.7.4.4: nucleoside-phosphate kinase

This is an abbreviated version!
For detailed information about nucleoside-phosphate kinase, go to the full flat file.

AMPK1, AMPK2, kinase, nucleoside monophosphate (phosphorylating), NMP kinase, NMP-kinase, nucleoside monophosphate kinase, thymidylate kinase, TMPK

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Results	in table
2	Activating Compound
2	AA Sequence
1	CAS Registry Number
5	Disease/ Diagnostics
6	Inhibitors
4	kcat/KM [mM/s]
4	KM Value [mM]
1	Localization
4	Metals/Ions
1	Natural Substrates/ Products (Substrates)
4	Organism
6	PDB ID
1	pH Range
2	pH Stability
2	Purification (Commentary)
1	Reaction
1	Reaction Type
4	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
9	Substrates and Products (Substrate)
9	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]
4	Turnover Number [1/s]

Inhibitors on EC 2.7.4.4 - nucleoside-phosphate kinase

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(E)-1-(5'-deoxy-thymidin-5'-yl)-vinyl boronic acid

about 30% inhibition at 1 mM

3-(thymin-1-yl)propylboronic acid

about 10% inhibition at 1 mM

[(E)-2-[(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl]ethenyl]boronic acid

about 15% inhibition at 1 mM

[2-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]ethyl]boronic acid

about 45% inhibition at 1 mM

[2-[(2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl]ethyl]boronic acid

about 25% inhibition at 1 mM

[2-[(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl]ethyl]boronic acid

about 55% inhibition at 1 mM