2.7.7.41: phosphatidate cytidylyltransferase
This is an abbreviated version!
For detailed information about phosphatidate cytidylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.41
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2.7.7.41
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phospholipid
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phosphatidylinositol
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phosphatidylglycerol
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cardiolipin
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cds1
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liponucleotide
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raetz
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phosphatidyltransferase
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diphosphate-diacylglycerol
- 2.7.7.41
- phospholipid
- phosphatidylinositol
- phosphatidylglycerol
- cardiolipin
- cds1
- liponucleotide
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raetz
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phosphatidyltransferase
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diphosphate-diacylglycerol
Reaction
Synonyms
CarS, CDP diacylglycerol synthase, CDP-DAG synthase, CDP-DG, CDP-DG synthase, CDP-DG synthetase, CDP-diacylglyceride synthetase, CDP-diacylglycerol synthase, CDP-diacylglycerol synthetase, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthetase, CDPdiglyceride pyrophosphorylase, CDS, CDS1, CDS2, CDS3, Cds4, Cds5, CdsA, CTP-diacylglycerol synthetase, CTP:1,2-diacylglycerophosphate-cytidyl transferase, CTP:phosphatidate cytidylyltransferase, cytidine 5'-diphosphate diacylglycerol synthase, cytidine diphosphoglyceride pyrophosphorylase, cytidinediphosphate diacylglycerol synthase, cytidylyltransferase, phosphatidate, DAG synthetase, More, phosphatidate cytidyltransferase, phosphatidate cytidyltransferase 2, phosphatidic acid cytidylyltransferase, SJAG_00426, Tam41, TAMM41, Tb927.7.220, TbCDS, YnbD
ECTree
2.7.7.41 phosphatidate cytidylyltransferaseAdvanced search results
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results (Engineering
Engineering on EC 2.7.7.41 - phosphatidate cytidylyltransferase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C102Y
mutation is the molecular basis for the inositol excretion phenotype
D220A
site-directed mutagenesis of TAM41, catalytically inactive mutant
Y130A
site-directed mutagenesis of TAM41, catalytically inactive mutant
C1226T/C1227T/P363S
additional information
C1226T/C1227T/P363S
construction of loss-of-function mutation in CDP-DG synthase in Schizosaccharomyces japonicus bbl1 mutant cells, the mutation triggers abnormal lipid droplet biogenesis and triacylglycerol accumulation. The P363S mutation in the Cds1 enzyme leads to a reduction in its CDP-DG synthase activity and potential shunting of a bulk of cellular phosphatidate into triacylglycerol biosynthesis through the DG pathway. The cds1bbl1 mutation is recessive, since introduction of the wild-type gene as an extra copy fully rescues the phenotype of bbl1 cells. Mutant bbl1 phenotype, overview
C1226T/C1227T/P363S
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construction of loss-of-function mutation in CDP-DG synthase in Schizosaccharomyces japonicus bbl1 mutant cells, the mutation triggers abnormal lipid droplet biogenesis and triacylglycerol accumulation. The P363S mutation in the Cds1 enzyme leads to a reduction in its CDP-DG synthase activity and potential shunting of a bulk of cellular phosphatidate into triacylglycerol biosynthesis through the DG pathway. The cds1bbl1 mutation is recessive, since introduction of the wild-type gene as an extra copy fully rescues the phenotype of bbl1 cells. Mutant bbl1 phenotype, overview
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additional information
generation of a T-DNA insertion (in the 5' untranslated region) mutant of CDS1, the cds1cds2 double mutant is seedling lethal, phenotypes, overview. The seedling-lethal phenotype of cds1cds2 double mutants can be rescued by inducing the expression of a functional CDS1 or CDS2 gene
additional information
generation of a T-DNA insertion (in the 5' untranslated region) mutant of CDS1, the cds1cds2 double mutant is seedling lethal, phenotypes, overview. The seedling-lethal phenotype of cds1cds2 double mutants can be rescued by inducing the expression of a functional CDS1 or CDS2 gene
additional information
generation of a T-DNA insertion (in the 5' untranslated region) mutant of CDS1, the cds1cds2 double mutant is seedling lethal, phenotypes, overview. The seedling-lethal phenotype of cds1cds2 double mutants can be rescued by inducing the expression of a functional CDS1 or CDS2 gene
additional information
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generation of a T-DNA insertion (in the 5' untranslated region) mutant of CDS1, the cds1cds2 double mutant is seedling lethal, phenotypes, overview. The seedling-lethal phenotype of cds1cds2 double mutants can be rescued by inducing the expression of a functional CDS1 or CDS2 gene
additional information
generation of a T-DNA insertion (in the 5' untranslated region) mutant of CDS2, the cds1cds2 double mutant is seedling lethal, phenotypes, overview. The seedling-lethal phenotype of cds1cds2 double mutants can be rescued by inducing the expression of a functional CDS1 or CDS2 gene
additional information
generation of a T-DNA insertion (in the 5' untranslated region) mutant of CDS2, the cds1cds2 double mutant is seedling lethal, phenotypes, overview. The seedling-lethal phenotype of cds1cds2 double mutants can be rescued by inducing the expression of a functional CDS1 or CDS2 gene
additional information
generation of a T-DNA insertion (in the 5' untranslated region) mutant of CDS2, the cds1cds2 double mutant is seedling lethal, phenotypes, overview. The seedling-lethal phenotype of cds1cds2 double mutants can be rescued by inducing the expression of a functional CDS1 or CDS2 gene
additional information
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generation of a T-DNA insertion (in the 5' untranslated region) mutant of CDS2, the cds1cds2 double mutant is seedling lethal, phenotypes, overview. The seedling-lethal phenotype of cds1cds2 double mutants can be rescued by inducing the expression of a functional CDS1 or CDS2 gene
additional information
transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS1 by 81%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells
additional information
transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS1 by 81%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells
additional information
transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS2 by 90%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells
additional information
transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS2 by 90%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells
additional information
transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS1 by 48%. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells
additional information
transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS1 by 48%. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells
additional information
transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS2 by 90%. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells
additional information
transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS2 by 90%. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells
additional information
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the cdsA-inactivated PAL mutant strain lacks phycobilisomes
additional information
generation of a conditional CDS knockout in the bloodstream form parasite, phenotype, overview
additional information
Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927
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generation of a conditional CDS knockout in the bloodstream form parasite, phenotype, overview
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