2.7.7.51: adenylylsulfate-ammonia adenylyltransferase
This is an abbreviated version!
For detailed information about adenylylsulfate-ammonia adenylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.51
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2.7.7.51
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fhits
-
fragile
-
polyphosphate
-
dinucleoside
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mycobacteria
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falciparum
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fluorogenic
-
suramin
-
triphosphatase
- 2.7.7.51
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fhits
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fragile
- polyphosphate
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dinucleoside
- mycobacteria
- falciparum
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fluorogenic
- suramin
- triphosphatase
Reaction
Synonyms
adenylyl sulfate:ammonia adenylyl transferase, adenylyltransferase, adenylylsulfate-ammonia, APSAT, diadenosine triphosphate hydrolase, Fhit, Fragile histidine triad protein
ECTree
2.7.7.51 adenylylsulfate-ammonia adenylyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.7.51 - adenylylsulfate-ammonia adenylyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
adenosine 5'-phosphorofluoridate + NH3
adenosine 5'-phosphoramidate + F-
-
-
-
?
adenosine 5'-phosphosulfate + NH3
adenosine 5'-phosphoramidate + SO42- + H+
-
-
-
?
cytidine 5'-phosphosulfate + NH3
cytidine 5'-phosphoramidate + SO42- + H+
91% of the rate with adenosine 5'-phosphosulfate
-
-
?
guanosine 5'-phosphosulfate + NH3
guanosine 5'-phosphoramidate + SO42- + H+
47% of the rate with adenosine 5'-phosphosulfate
-
-
?
uridine 5'-phosphosulfate + NH3
uridine 5'-phosphoramidate + SO42- + H+
56% of the rate with adenosine 5'-phosphosulfate
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
a large variety of ammonia analogs such as amines, amides etc. can not replace ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
very high specificity for the adenylylsulfate and ammonia
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
-
the product adenosine 5'-phosphoramidate replaces AMP as an activator of phosphorylase b, threonine dehydratase and adenylate cyclase
-
-
?
additional information
?
-
enzyme catalyses ammonolysis of adenosine 5'-phosphosulfate, which results in the formation of adenosine 5'-phosphoramidate. The mechanism for Fhit-catalysed ammonolysis of these substrates most probably involves attack by NH3 on the covalent histidine-bound enzyme-nucleosidyl intermediate. No substrate: adenosine 5'-phosphosulfate-3-phosphate
-
-
?
additional information
?
-
-
enzyme catalyses ammonolysis of adenosine 5'-phosphosulfate, which results in the formation of adenosine 5'-phosphoramidate. The mechanism for Fhit-catalysed ammonolysis of these substrates most probably involves attack by NH3 on the covalent histidine-bound enzyme-nucleosidyl intermediate. No substrate: adenosine 5'-phosphosulfate-3-phosphate
-
-
?
