Information on EC 2.1.1.131 - precorrin-3B C17-methyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.1.1.131
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RECOMMENDED NAME
GeneOntology No.
precorrin-3B C17-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
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vitamin B12 metabolism
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Porphyrin and chlorophyll metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase
In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively.
CAS REGISTRY NUMBER
COMMENTARY hide
152787-64-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene cobJ
SwissProt
Manually annotated by BRENDA team
i.e. Propionibacterium shermanii, gene cbiH
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cobalt-precorrin-3
S-adenosyl-L-homocysteine + cobalt-precorrin-4
show the reaction diagram
S-adenosyl-L-methionine + cobalt-precorrin-3B
S-adenosyl-L-homocysteine + cobalt-precorrin-4
show the reaction diagram
S-Adenosyl-L-methionine + precorrin-3B
?
show the reaction diagram
S-Adenosyl-L-methionine + precorrin-3B
S-Adenosyl-L-homocysteine + precorrin-4
show the reaction diagram
additional information
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cobalt-precorrin-3B
S-adenosyl-L-homocysteine + cobalt-precorrin-4
show the reaction diagram
S-Adenosyl-L-methionine + precorrin-3B
?
show the reaction diagram
S-Adenosyl-L-methionine + precorrin-3B
S-Adenosyl-L-homocysteine + precorrin-4
show the reaction diagram
Q9R9K1
enzyme is involved in the aerobic cobalamin biosynthesis
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?
additional information
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 91400, about, cbiEGH protein, amino acid sequence calculation and SDS-PAGE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene cbiEGH, the gene cbiH of Propionibacterium freudenreichii is organized in a single ORF with genes cbiE and cbiG, DNA and amino acid sequence determination and analysis, genetic organization, co-overexpression of enzymes and reconstruction of the anaerobic cobalamin biosynthetic pathway in Escherichia coli in a construct comprising several genes, overview
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gene cobJ, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in a pleiotropic mutant strain high has a severe defect in anaerobic growth, the phenotype can be reversed by cobalamin and complemented by expression of genes of the cobalamin biosynthetic pathway, overview
overexpression in Escherichia coli
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Show AA Sequence (1211 entries)
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