1.14.13.158: amorpha-4,11-diene 12-monooxygenase

This is an abbreviated version, for detailed information about amorpha-4,11-diene 12-monooxygenase, go to the full flat file.

Reaction

amorpha-4,11-diene
+ 3 O2 + 3 NADPH + 3 H+ =
artemisinate
+ 3 NADP+ + 4 H2O

Synonyms

ALDH1, amorpha-4,11-diene C-12 oxidase, CYP71AV1, cytochrome P450 monooxygenase 71 AV1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.158 amorpha-4,11-diene 12-monooxygenase

Source Tissue

Source Tissue on EC 1.14.13.158 - amorpha-4,11-diene 12-monooxygenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
expression of farnesyl diphosphate synthase takes place in apical and sub-apical cells as well as in mesophyl cells while the three enzymes involved in artemisinin biosynthesis, i.e. amorpha-4,11-diene synthase, amorpha-4,11-diene hydroxylase, a cytochrome P450 monooxygenase, and artemisinic aldehyde DELTA11(13) reductase are expressed only in the apical cells
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
low expression
Manually annotated by BRENDA team