1.14.13.158: amorpha-4,11-diene 12-monooxygenase

This is an abbreviated version!
For detailed information about amorpha-4,11-diene 12-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.158

transferred to EC 1.14.14.114


Synonyms

amorpha-4,11-diene C-12 oxidase, amorpha-4,11-diene monooxygenase, CYP71AV1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.158 amorpha-4,11-diene 12-monooxygenase

Substrates Products

Substrates Products on EC 1.14.13.158 - amorpha-4,11-diene 12-monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
amorpha-4,11-diene + 3 O2 + 3 NADPH + 3 H+
artemisinate + 3 NADP+ + 4 H2O
show the reaction diagram
amorpha-4,11-diene + O2 + NADPH + H+
artemisinic alcohol + NADP+ + H2O
show the reaction diagram
artemisinic alcohol + O2 + NADPH + H+
artemisinic aldehyde + NADP+ + 2 H2O
show the reaction diagram
artemisinic aldehyde + O2 + NADPH + H+
artemisinate + NADP+ + H2O
show the reaction diagram
additional information
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conversion of dihydroartemsinic aldehyde to artemisinate is nonenzymatic in trichomes by nonenzymatic autoxidation of dihydroartemsinic aldehyde to dihydroartemsinic acid tertiary hydroperoxide and subsequent nonenzymatic rearrangement to artemisinin
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