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EC 2.7.2.1 Details

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EC number

2.7.2.1

Accepted name

acetate kinase

Reaction

ATP + acetate = ADP + acetyl phosphate

Other name(s)

acetokinase, AckA, AK, acetic kinase, acetate kinase (phosphorylating)

Systematic name

ATP:acetate phosphotransferase

CAS registry number

9027-42-3

Comment

Requires Mg²⁺ for activity. While purified enzyme from Escherichia coli is specific for acetate [4], others have found that the enzyme can also use propanoate as a substrate, but more slowly [7]. Acetate can be converted into the key metabolic intermediate acetyl-CoA by coupling acetate kinase with EC 2.3.1.8, phosphate acetyltransferase. Both this enzyme and EC 2.7.2.15, propionate kinase, play important roles in the production of propanoate [9].

History

created 1961, modified 2005

EC Tree

1 Oxidoreductases

2 Transferases

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.2 Phosphotransferases with a carboxy group as acceptor

2.7.2.1 acetate kinase

2.7.2.2 carbamate kinase

2.7.2.3 phosphoglycerate kinase

2.7.2.4 aspartate kinase

2.7.2.5 created 1965, deleted 1978

2.7.2.6 formate kinase

2.7.2.7 butyrate kinase

2.7.2.8 acetylglutamate kinase

2.7.2.9 created 1972, deleted 1978

2.7.2.10 phosphoglycerate kinase (GTP)

2.7.2.11 glutamate 5-kinase

2.7.2.12 acetate kinase (diphosphate)

2.7.2.13 glutamate 1-kinase

2.7.2.14 branched-chain-fatty-acid kinase

2.7.2.15 propionate kinase

2.7.2.16 2-phosphoglycerate kinase

2.7.2.17 [amino-group carrier protein]-L-2-aminoadipate 6-kinase

2.7.2.18 fatty acid kinase

2.7.2.19 [amino-group carrier protein]-L-glutamate 6-kinase

2.7.3 Phosphotransferases with a nitrogenous group as acceptor

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)

2.7.6 Diphosphotransferases

2.7.7 Nucleotidyltransferases

2.7.8 Transferases for other substituted phosphate groups

2.7.9 Phosphotransferases with paired acceptors

2.7.10 Protein-tyrosine kinases

2.7.11 Protein-serine/threonine kinases

2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)

2.7.13 Protein-histidine kinases

2.7.14 Protein-arginine kinases

2.7.99 Other protein kinases

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups