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EC 3.6.3.44 Details
EC number
3.6.3.44
Accepted name
xenobiotic-transporting ATPase
Reaction
ATP + H2O + xenobioticin = ADP + phosphate + xenobioticout
Other name(s)
multidrug-resistance protein,
MDR protein,
P-glycoprotein,
pleiotropic-drug-resistance protein,
PDR protein,
steroid-transporting ATPase,
ATP phosphohydrolase (steroid-exporting)
Systematic name
ATP phosphohydrolase (xenobiotic-exporting)
Comment
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. The enzyme from Gram-positive bacteria and eukaryotic cells export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione—drug conjugates. Some also show some ’flippase’ (phospholipid-translocating ATPase; EC 3.6.3.1) activity.
History
created 2000 (EC 3.6.3.45 incorporated 2006), modified 2006, deleted 2018
EC Tree
3.6.3.13 created 2000, deleted 2001