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EC 4.2.3.5 Details
EC number
4.2.3.5
Accepted name
chorismate synthase
Reaction
5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
Other name(s)
5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase
Systematic name
5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)
CAS registry number
9077-07-0
Comment
Requires FMN. The reaction goes via a radical mechanism that involves reduced FMN and its semiquinone (FMNH·). Shikimate is numbered so that the double-bond is between C-1 and C-2, but some earlier papers numbered the ring in the reverse direction.
History
created 1978 as EC 4.6.1.4, modified 1983, transferred 2000 to EC 4.2.3.5, modified 2002
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
4 Lyases
4.1 Carbon-carbon lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.2 Acting on polysaccharides
4.2.3 Acting on phosphates
4.2.3.1 threonine synthase
4.2.3.2 ethanolamine-phosphate phospho-lyase
4.2.3.3 methylglyoxal synthase
4.2.3.4 3-dehydroquinate synthase
4.2.3.5 chorismate synthase
4.2.3.6 trichodiene synthase
4.2.3.7 pentalenene synthase
4.2.3.8 casbene synthase
4.2.3.9 aristolochene synthase
4.2.3.10 (-)-endo-fenchol synthase
4.2.3.11 sabinene-hydrate synthase
4.2.3.12 6-pyruvoyltetrahydropterin synthase
4.2.3.13 (+)-δ-cadinene synthase
4.2.3.14 pinene synthase
4.2.3.15 myrcene synthase
4.2.3.16 (4S)-limonene synthase
4.2.3.17 taxadiene synthase
4.2.3.18 abieta-7,13-diene synthase
4.2.3.19 ent-kaurene synthase
4.2.3.20 (R)-limonene synthase
4.2.3.21 vetispiradiene synthase
4.2.3.22 germacradienol synthase
4.2.3.23 germacrene-A synthase
4.2.3.24 amorpha-4,11-diene synthase
4.2.3.25 S-linalool synthase
4.2.3.26 R-linalool synthase
4.2.3.27 isoprene synthase
4.2.3.28 ent-cassa-12,15-diene synthase
4.2.3.29 ent-sandaracopimaradiene synthase
4.2.3.30 ent-pimara-8(14),15-diene synthase
4.2.3.31 ent-pimara-9(11),15-diene synthase
4.2.3.32 levopimaradiene synthase
4.2.3.33 stemar-13-ene synthase
4.2.3.34 stemod-13(17)-ene synthase
4.2.3.35 syn-pimara-7,15-diene synthase
4.2.3.36 terpentetriene synthase
4.2.3.37 epi-isozizaene synthase
4.2.3.38 α-bisabolene synthase
4.2.3.39 epi-cedrol synthase
4.2.3.40 (Z)-γ-bisabolene synthase
4.2.3.41 elisabethatriene synthase
4.2.3.42 aphidicolan-16β-ol synthase
4.2.3.43 fusicocca-2,10(14)-diene synthase
4.2.3.44 isopimara-7,15-diene synthase
4.2.3.45 phyllocladan-16α-ol synthase
4.2.3.46 α-farnesene synthase
4.2.3.47 β-farnesene synthase
4.2.3.48 (3S,6E)-nerolidol synthase
4.2.3.49 (3R,6E)-nerolidol synthase
4.2.3.50 (+)-α-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
4.2.3.51 β-phellandrene synthase (neryl-diphosphate-cyclizing)
4.2.3.52 (4S)-β-phellandrene synthase (geranyl-diphosphate-cyclizing)
4.2.3.53 (+)-endo-β-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
4.2.3.54 (-)-endo-α-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
4.2.3.55 (S)-β-bisabolene synthase
4.2.3.56 γ-humulene synthase
4.2.3.57 (-)-β-caryophyllene synthase
4.2.3.58 longifolene synthase
4.2.3.59 (E)-γ-bisabolene synthase
4.2.3.60 germacrene C synthase
4.2.3.61 5-epiaristolochene synthase
4.2.3.62 (-)-γ-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]
4.2.3.63 (+)-cubenene synthase
4.2.3.64 (+)-epicubenol synthase
4.2.3.65 zingiberene synthase
4.2.3.66 β-selinene cyclase
4.2.3.67 cis-muuroladiene synthase
4.2.3.68 β-eudesmol synthase
4.2.3.69 (+)-α-barbatene synthase
4.2.3.70 patchoulol synthase
4.2.3.71 (E,E)-germacrene B synthase
4.2.3.72 α-gurjunene synthase
4.2.3.73 valencene synthase
4.2.3.74 presilphiperfolanol synthase
4.2.3.75 (-)-germacrene D synthase
4.2.3.76 (+)-δ-selinene synthase
4.2.3.77 (+)-germacrene D synthase
4.2.3.78 β-chamigrene synthase
4.2.3.79 thujopsene synthase
4.2.3.80 α-longipinene synthase
4.2.3.81 exo-α-bergamotene synthase
4.2.3.82 α-santalene synthase
4.2.3.83 β-santalene synthase
4.2.3.84 10-epi-γ-eudesmol synthase
4.2.3.85 α-eudesmol synthase
4.2.3.86 7-epi-α-selinene synthase
4.2.3.87 α-guaiene synthase
4.2.3.88 viridiflorene synthase
4.2.3.89 (+)-β-caryophyllene synthase
4.2.3.90 5-epi-α-selinene synthase
4.2.3.91 cubebol synthase
4.2.3.92 (+)-γ-cadinene synthase
4.2.3.93 δ-guaiene synthase
4.2.3.94 γ-curcumene synthase
4.2.3.95 (-)-α-cuprenene synthase
4.2.3.96 avermitilol synthase
4.2.3.97 (-)-δ-cadinene synthase
4.2.3.98 (+)-T-muurolol synthase
4.2.3.99 labdatriene synthase
4.2.3.100 bicyclogermacrene synthase
4.2.3.101 7-epi-sesquithujene synthase
4.2.3.102 sesquithujene synthase
4.2.3.103 ent-isokaurene synthase
4.2.3.104 α-humulene synthase
4.2.3.105 tricyclene synthase
4.2.3.106 (E)-β-ocimene synthase
4.2.3.107 (+)-car-3-ene synthase
4.2.3.108 1,8-cineole synthase
4.2.3.109 (-)-sabinene synthase
4.2.3.110 (+)-sabinene synthase
4.2.3.111 (-)-α-terpineol synthase
4.2.3.112 (+)-α-terpineol synthase
4.2.3.113 terpinolene synthase
4.2.3.114 γ-terpinene synthase
4.2.3.115 α-terpinene synthase
4.2.3.116 (+)-camphene synthase
4.2.3.117 (-)-camphene synthase
4.2.3.118 2-methylisoborneol synthase
4.2.3.119 (-)-α-pinene synthase
4.2.3.120 (-)-β-pinene synthase
4.2.3.121 (+)-α-pinene synthase
4.2.3.122 (+)-β-pinene synthase
4.2.3.123 β-sesquiphellandrene synthase
4.2.3.124 2-deoxy-scyllo-inosose synthase
4.2.3.125 α-muurolene synthase
4.2.3.126 γ-muurolene synthase
4.2.3.127 β-copaene synthase
4.2.3.128 β-cubebene synthase
4.2.3.129 (+)-sativene synthase
4.2.3.130 tetraprenyl-β-curcumene synthase
4.2.3.131 miltiradiene synthase
4.2.3.132 neoabietadiene synthase
4.2.3.133 α-copaene synthase
4.2.3.134 5-phosphooxy-L-lysine phospho-lyase
4.2.3.135 Δ6-protoilludene synthase
4.2.3.136 α-isocomene synthase
4.2.3.137 (E)-2-epi-β-caryophyllene synthase
4.2.3.138 (+)-epi-α-bisabolol synthase
4.2.3.139 valerena-4,7(11)-diene synthase
4.2.3.140 cis-abienol synthase
4.2.3.141 sclareol synthase
4.2.3.142 7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
4.2.3.143 kunzeaol synthase
4.2.3.144 geranyllinalool synthase
4.2.3.145 ophiobolin F synthase
4.2.3.146 cyclooctat-9-en-7-ol synthase
4.2.3.147 pimaradiene synthase
4.2.3.148 cembrene C synthase
4.2.3.149 nephthenol synthase
4.2.3.150 cembrene A synthase
4.2.3.151 pentamethylcyclopentadecatrienol synthase
4.2.3.152 2-epi-5-epi-valiolone synthase
4.2.3.153 (5-formylfuran-3-yl)methyl phosphate synthase
4.2.3.154 demethyl-4-deoxygadusol synthase
4.2.3.155 2-epi-valiolone synthase
4.2.3.156 hydroxysqualene synthase
4.2.3.157 (+)-isoafricanol synthase
4.2.3.158 (–)-spiroviolene synthase
4.2.3.159 tsukubadiene synthase
4.2.3.160 (2S,3R,6S,9S)-(–)-protoillud-7-ene synthase
4.2.3.161 (3S)-(+)-asterisca-2(9),6-diene synthase
4.2.3.162 (–)-α-amorphene synthase
4.2.3.163 (+)-corvol ether B synthase
4.2.3.164 (+)-eremophilene synthase
4.2.3.165 (1R,4R,5S)-(–)-guaia-6,10(14)-diene synthase
4.2.3.166 (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol synthase
4.2.3.167 dolabella-3,7-dien-18-ol synthase
4.2.3.168 dolathalia-3,7,11-triene synthase
4.2.3.169 7-epi-α-eudesmol synthase
4.2.3.170 4-epi-cubebol synthase
4.2.3.171 (+)-corvol ether A synthase
4.2.3.172 10-epi-juneol synthase
4.2.3.173 τ-cadinol synthase
4.2.3.174 (2E,6E)-hedycaryol synthase
4.2.3.175 10-epi-cubebol synthase
4.2.3.176 sesterfisherol synthase
4.2.3.177 β-thujene synthase
4.2.3.178 stellata-2,6,19-triene synthase
4.2.3.179 guaia-4,6-diene synthase
4.2.3.180 pseudolaratriene synthase
4.2.3.181 selina-4(15),7(11)-diene synthase
4.2.3.182 pristinol synthase
4.2.3.183 nezukol synthase
4.2.3.184 5-hydroxy-α-gurjunene synthase
4.2.3.185 ent-atiserene synthase
4.2.3.186 ent-13-epi-manoyl oxide synthase
4.2.3.187 (2Z,6E)-hedycaryol synthase
4.2.3.188 β-geranylfarnesene synthase
4.2.3.189 9,13-epoxylabd-14-ene synthase
4.2.3.190 manoyl oxide synthase
4.2.3.191 cycloaraneosene synthase
4.2.3.192 labda-7,13(16),14-triene synthase
4.2.3.193 (12E)-labda-8(17),12,14-triene synthase
4.2.3.194 (–)-drimenol synthase
4.2.3.195 rhizathalene A synthase
4.2.3.196 dolabradiene synthase
4.2.3.197 eudesmane-5,11-diol synthase
4.2.3.198 α-selinene synthase
4.2.3.199 (–)-5-epieremophilene synthase
4.2.3.200 β-pinacene synthase
4.2.3.201 hydropyrene synthase
4.2.3.202 hydropyrenol synthase
4.2.3.203 isoelisabethatriene synthase
4.2.3.204 valerianol synthase
4.2.3.205 sodorifen synthase
4.2.99 Other carbon-oxygen lyases
4.3 Carbon-nitrogen lyases
4.4 Carbon-sulfur lyases
4.5 Carbon-halide lyases
4.6 Phosphorus-oxygen lyases
4.7 carbon-phosphorus lyases
4.8 Nitrogen-oxygen lyases
4.98 ATP-independent chelatases
4.99 Other lyases
5 Isomerases
6 Ligases
7 Translocases