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EC 5.2.1.8 Details
show Brenda entryEC number
5.2.1.8
Accepted name
peptidylprolyl isomerase
Reaction
peptidylproline (ω=180) = peptidylproline (ω=0)
Other name(s)
PPIase,
cyclophilin [misleading, see comments],
peptide bond isomerase,
peptidyl-prolyl cis-trans isomerase
Systematic name
peptidylproline cis-trans-isomerase
CAS registry number
95076-93-0
Comment
The first type of this enzyme found [1] proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
History
created 1989, modified 2002
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1 Oxidoreductases
5 Isomerases
5.2.1.11 created 1992, deleted 2005
