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EC 6.3.1.2 Details
show Brenda entryEC number
6.3.1.2
Accepted name
glutamine synthetase
Reaction
ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine
Other name(s)
glutamate—ammonia ligase,
glutamylhydroxamic synthetase,
L-glutamine synthetase,
GS
Systematic name
L-glutamate:ammonia ligase (ADP-forming)
CAS registry number
9023-70-5
Comment
Glutamine synthetase, which catalyses the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. Several types have been described, differing in their oligomeric structures and cofactor requirements.
History
created 1961, modified 2016
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1 Oxidoreductases
6 Ligases
6.3.1.3 created 1961, deleted 1972
