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Information on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+) for references in articles please use BRENDA:EC1.1.1.197Word Map on EC 1.1.1.197
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The enzyme appears in viruses and cellular organisms
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15-hydroxyprostaglandin dehydrogenase (NADP+)
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(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2[cf. EC1.1.1.141 (NADP)]. May be identical with EC1.1.1.189 prostaglandin-E2 9-reductase
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(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.
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9-ketoprostaglandin reductase
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NADP-dependent 15-hydroxyprostaglandin dehydrogenase
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NADP-linked 15-hydroxyprostglandin dehydrogenase
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NADP-specific 15-hydroxyprostaglandin dehydrogenase
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prostaglandin 9-ketoreductase
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prostaglandin E 9-ketoreductase
type II 15-hydroxyprostaglandin dehydrogenase
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prostaglandin E 9-ketoreductase
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prostaglandin E 9-ketoreductase
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bovine
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human
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Swissprot
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rat, Holtzman
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porcine
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brenda
swine
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brenda
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2-methyl-3-glutathionyl-1,4-benzoquinone + NADPH
? + NADP+
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toluquinone thioether
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?
2-methyl-3-glutathionyl-1,4-naphthoquinone + NADPH
? + NADP+
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menadione thioether
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?
4,5-benzo[a]pyrenequinone + NADPH
? + NADP+
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?
5,6-chrysenequinone + NADPH
? + NADP+
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?
7,8-benzo[a]pyrenequinone + NADPH
? + NADP+
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?
9,10-phenanthrenequinone + NADPH
? + NADP+
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?
acid form of latanoprost + NADP+
? + NADPH
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?
glutathione-9-hydroxy-prostaglandin A1 thioether + NADP+
? + NADPH
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?
glutathione-prostaglandin A1 thioether + NADP+
? + NADPH
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PGA1-SG, excellent substrate for the placental enzyme
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?
latanoprost + NADP+
? + NADPH
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?
menadione + NADPH
? + NADP+
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?
prostaglandin A1 + NADP+
15-oxoprostaglandin A1 + NADPH + H+
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?
prostaglandin B1 + NADP+
15-oxoprostaglandin B1 + NADPH + H+
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?
prostaglandin E + NADP+
? + NADPH
prostaglandin E1 + NADP+
15-keto-prostaglandin E1 + NADPH + H+
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?
prostaglandin E2 + NADP+
15-oxoprostaglandin E2 + NADPH + H+
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?
prostaglandin E2 + NADP+
prostaglandin F2alpha + NADPH
prostaglandin F + NADP+
? + NADPH
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
prostaglandin I2 + NADP+
? + NADPH
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poor substrate for the enzyme
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?
thromboxane B2 + NADP+
? + NADPH
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slowly oxidized
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?
toluquinone + NADPH
? + NADP+
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?
additional information
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the trans-dihydrodiols trans-dihydroxy-4,5-dihydrobenzo[alpha]pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene, trans-3,4-dihydroxy-3,4-dihydrobenz[alpha]anthracene and its 7-methyl, 12-methyl, and 7,12-dimethyl derivatives are not substrates for the enzyme
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prostaglandin E + NADP+
? + NADPH
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?
prostaglandin E + NADP+
? + NADPH
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r
prostaglandin E2 + NADP+
prostaglandin F2alpha + NADPH
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?
prostaglandin E2 + NADP+
prostaglandin F2alpha + NADPH
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biological inactivation of prostaglandins is mediated by the enzyme
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r
prostaglandin E2 + NADP+
prostaglandin F2alpha + NADPH
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?
prostaglandin F + NADP+
? + NADPH
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?
prostaglandin F + NADP+
? + NADPH
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r
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
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?
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
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r
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
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?
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prostaglandin E2 + NADP+
15-oxoprostaglandin E2 + NADPH + H+
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?
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NADP+
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1-glutathionyl-2-hydroxy-3(allyloxy)propane
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competitive inhibition of prostaglandin B1 oxidation
beta-Mercaptopyruvate
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glutathione-9-hydroxy-prostaglandin A1 thioether
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inhibition of polycyclic aromatic hydrocarbon quinone reduction
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0.0024
2-methyl-3-glutathionyl-1,4-benzoquinone
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0.0034
2-methyl-3-glutathionyl-1,4-naphthoquinone
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0.00018
4,5-benzo[a]pyrenequinone
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0.00051
5,6-chrysenequinone
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0.00087
7,8-benzo[a]pyrenequinone
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0.00036
9,10-phenanthrenequinone
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0.00033
glutathione-prostaglandin A1 thioether
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0.09
prostaglandin A1
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0.157
prostaglandin E1
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0.0012
substrate latanoprost, pH 7.0, 25°C
0.0022
substrate acid form of latanoprost, pH 7.0, 25°C
0.0061
substrate prostaglandin F2alpha, cosubstrate NAD+, pH 7.0, 25°C
0.0098
substrate prostaglandin E2, cosubstrate NADP+, pH 7.0, 25°C
0.0243
substrate prostaglandin F2alpha, cosubstrate NADP+, pH 7.0, 25°C
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mesenteric vessels, arteries and veins
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epithelial cells of cornea
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brenda
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brenda
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brenda
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30500
x * 30500, deduced from gene sequence, x * 31000, SDS-PAGE
31000
x * 30500, deduced from gene sequence, x * 31000, SDS-PAGE
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?
x * 30500, deduced from gene sequence, x * 31000, SDS-PAGE
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CBR1_BOVIN
277
30533
Swiss-Prot
CBR1_HUMAN
277
30375
Swiss-Prot
CBR1_MACFA
277
30473
Swiss-Prot
CBR1_MOUSE
277
30641
Swiss-Prot
CBR1_PIG
289
31693
Swiss-Prot
CBR1_PONAB
277
30391
Swiss-Prot
CBR1_RABIT
277
30452
Swiss-Prot
CBR1_RAT
277
30578
Swiss-Prot
A0A0B2RJ58_GLYSO
303
33173
TrEMBL
A0A0C1C1D0_9BACT
241
26248
TrEMBL
G0QZX6_ICHMG
Ichthyophthirius multifiliis (strain G5)
223
26040
TrEMBL
F8L0N3_PARAV
Parachlamydia acanthamoebae (strain UV7)
231
24993
TrEMBL
A0A2I0AXJ8_9ASPA
315
35128
TrEMBL
Q097P7_STIAD
Stigmatella aurantiaca (strain DW4/3-1)
234
25733
TrEMBL
Q09E76_STIAD
Stigmatella aurantiaca (strain DW4/3-1)
234
26134
TrEMBL
A0A0B2RU65_GLYSO
77
8367
TrEMBL
A0A1Z5K650_FISSO
276
30071
TrEMBL
G0QL08_ICHMG
Ichthyophthirius multifiliis (strain G5)
272
31160
TrEMBL
A0A0B8NGM8_9NOCA
281
29530
TrEMBL
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Westbrook, C.; Lin, Y.M.; Jarabak, J.
NADP-linked 15-hydroxyprostaglandin dehydrogenase from human placenta: partial purification and characterization of the enzyme and identification of an inhibitor in placental tissue
Biochem. Biophys. Res. Commun.
76
943-949
1977
Homo sapiens
brenda
Wong, P.Y.K.; McGiff, J.C.
Detection of 15-hydroxyprostaglandin dehydrogenase in bovine mesenteric blood vessels
Biochim. Biophys. Acta
500
436-439
1977
Bos taurus
brenda
Jarabak, J.; Fried, J.
Comparison of substrate specificities of the human placental NAD-and NADP-linked 15-hydroxyprostaglandin dehydrogenases
Prostaglandins
18
241-246
1979
Homo sapiens
brenda
Levasseur, S.; Friedman, Y.; Burke, G.
Prostaglandin metabolism in the rat adrenal cortex: Characterization of prostaglandin-9-ketoreductase and 15-hydroxyprostaglandin dehydrogenase
Biochem. Biophys. Res. Commun.
95
236-242
1980
Homo sapiens, Platyrrhini, Rattus norvegicus
brenda
Chang, D.B.G; Sun, M.; Tai, H.H.
Prostaglandin-9-ketoreductase and type II 15-hydroxyprostaglandin dehydrogenase from swine kidney are alternate activities of a single enzyme protein
Biochem. Biophys. Res. Commun.
99
745-751
1981
Homo sapiens, Sus scrofa
brenda
Tai, H.H.; Chang, D.B.G.
Purification of NADP+/NADPH-dependent 15-hydroxyprostaglandin dehydrogenase and prostaglandin 9-ketoreductase from porcine kidney
Methods Enzymol.
86
142-147
1982
Sus scrofa
brenda
Chung, H.; Fried, J.; Williams-Ashman, E.; Jarabak, J.
Glutathione mixed disulfide inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase
Prostaglandins
33
383-390
1987
Homo sapiens
brenda
Chung, H.; Harvey, R.G.; Armstrong, R.N.; Jarabak, J.
Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase
J. Biol. Chem.
262
12448-12451
1987
Homo sapiens
brenda
Wermuth, B.
NADP-dependent 15-hydroxyprostaglandin dehydrogenase is homologous to NAD-dependent 15-hydroxyprostaglandin dehydrogenase and other short-chain alcohol dehydrogenases
Prostaglandins
44
5-9
1992
Homo sapiens
brenda
Krook, M.; Ghosh, D.; Duax, W.; Jörnvall, H.
Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase)
FEBS Lett.
322
139-142
1993
Homo sapiens
brenda
Fujimori, K.; Okada, T.; Urade, Y.
Expression of NADP(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase mRNA in Monkey Ocular Tissues and Characterization of Its Recombinant Enzyme
J. Biochem.
131
383-389
2002
Macaca fascicularis (Q8MI29)
brenda
Krook, M.; Ghosh, D.; Stromberg, R.; Carlquist, M.; Jornvall, H.
Carboxyethyllysine in a protein: Native carbonyl reductase/NADP+-dependent prostaglandin dehydrogenase
Proc. Natl. Acad. Sci. USA
90
502-506
1993
Homo sapiens
brenda
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