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2-methyl-3-glutathionyl-1,4-benzoquinone + NADPH
? + NADP+
-
Substrates: toluquinone thioether
Products: -
?
2-methyl-3-glutathionyl-1,4-naphthoquinone + NADPH
? + NADP+
-
Substrates: menadione thioether
Products: -
?
4,5-benzo[a]pyrenequinone + NADPH
? + NADP+
-
Substrates: -
Products: -
?
5,6-chrysenequinone + NADPH
? + NADP+
-
Substrates: -
Products: -
?
7,8-benzo[a]pyrenequinone + NADPH
? + NADP+
-
Substrates: -
Products: -
?
9,10-phenanthrenequinone + NADPH
? + NADP+
-
Substrates: -
Products: -
?
acid form of latanoprost + NADP+
? + NADPH
Substrates: -
Products: -
?
glutathione-9-hydroxy-prostaglandin A1 thioether + NADP+
? + NADPH
-
Substrates: -
Products: -
?
glutathione-prostaglandin A1 thioether + NADP+
? + NADPH
-
Substrates: PGA1-SG, excellent substrate for the placental enzyme
Products: -
?
latanoprost + NADP+
? + NADPH
Substrates: -
Products: -
?
menadione + NADPH
? + NADP+
-
Substrates: -
Products: -
?
prostaglandin A1 + NADP+
15-oxoprostaglandin A1 + NADPH + H+
-
Substrates: -
Products: -
?
prostaglandin B1 + NADP+
15-oxoprostaglandin B1 + NADPH + H+
-
Substrates: -
Products: -
?
prostaglandin E1 + NADP+
15-keto-prostaglandin E1 + NADPH + H+
-
Substrates: -
Products: -
?
prostaglandin E2 + NADP+
15-oxoprostaglandin E2 + NADPH + H+
-
Substrates: -
Products: -
?
prostaglandin E2 + NADPH + H+
prostaglandin F2 + NADP+
prostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NADP+
prostaglandin F + NADP+
? + NADPH
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
prostaglandin I2 + NADP+
? + NADPH
-
Substrates: poor substrate for the enzyme
Products: -
?
thromboxane B2 + NADP+
? + NADPH
-
Substrates: slowly oxidized
Products: -
?
toluquinone + NADPH
? + NADP+
-
Substrates: -
Products: -
?
additional information
?
-
-
Substrates: the trans-dihydrodiols trans-dihydroxy-4,5-dihydrobenzo[alpha]pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene, trans-3,4-dihydroxy-3,4-dihydrobenz[alpha]anthracene and its 7-methyl, 12-methyl, and 7,12-dimethyl derivatives are not substrates for the enzyme
Products: -
?
prostaglandin E2 + NADPH + H+
prostaglandin F2 + NADP+
-
Substrates: -
Products: -
?
prostaglandin E2 + NADPH + H+
prostaglandin F2 + NADP+
-
Substrates: -
Products: -
r
prostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
Substrates: -
Products: -
?
prostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
Substrates: biological inactivation of prostaglandins is mediated by the enzyme
Products: -
r
prostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NADP+
Substrates: -
Products: -
?
prostaglandin F + NADP+
? + NADPH
-
Substrates: -
Products: -
?
prostaglandin F + NADP+
? + NADPH
-
Substrates: -
Products: -
r
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
-
Substrates: -
Products: -
?
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
-
Substrates: -
Products: -
r
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
Substrates: -
Products: -
?
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CBR1_BOVIN
277
0
30533
Swiss-Prot
other Location (Reliability: 5)
CBR1_HUMAN
277
0
30375
Swiss-Prot
other Location (Reliability: 4)
CBR1_MACFA
277
0
30473
Swiss-Prot
Mitochondrion (Reliability: 4)
CBR1_MOUSE
277
0
30641
Swiss-Prot
Mitochondrion (Reliability: 5)
CBR1_PIG
289
0
31693
Swiss-Prot
Mitochondrion (Reliability: 3)
CBR1_PONAB
277
0
30391
Swiss-Prot
other Location (Reliability: 5)
CBR1_RABIT
277
0
30452
Swiss-Prot
Mitochondrion (Reliability: 4)
CBR1_RAT
277
0
30578
Swiss-Prot
other Location (Reliability: 4)
A0A5B7BAK0_DAVIN
281
0
30920
TrEMBL
Mitochondrion (Reliability: 4)
A0A0C1C1D0_9BACT
241
0
26248
TrEMBL
-
A0A0B2RJ58_GLYSO
303
0
33173
TrEMBL
other Location (Reliability: 3)
F8L0N3_PARAV
Parachlamydia acanthamoebae (strain UV7)
231
0
24993
TrEMBL
-
Q09E76_STIAD
Stigmatella aurantiaca (strain DW4/3-1)
234
0
26134
TrEMBL
-
G0QL08_ICHMG
Ichthyophthirius multifiliis (strain G5)
272
0
31160
TrEMBL
other Location (Reliability: 3)
Q097P7_STIAD
Stigmatella aurantiaca (strain DW4/3-1)
234
0
25733
TrEMBL
-
A0A0B8NGM8_9NOCA
281
0
29530
TrEMBL
-
A0A6J8BIX3_MYTCO
281
0
30784
TrEMBL
Mitochondrion (Reliability: 3)
G0QZX6_ICHMG
Ichthyophthirius multifiliis (strain G5)
223
0
26040
TrEMBL
other Location (Reliability: 2)
B6R2U0_9HYPH
219
0
23470
TrEMBL
-
A0A1Z5K650_FISSO
276
0
30071
TrEMBL
other Location (Reliability: 4)
A0A1Z5JLW5_FISSO
276
0
30188
TrEMBL
other Location (Reliability: 3)
A0A0B2RU65_GLYSO
77
0
8367
TrEMBL
other Location (Reliability: 4)
A0A812B6N7_SEPPH
774
0
84138
TrEMBL
Mitochondrion (Reliability: 5)
A0A812E5X8_SEPPH
238
0
26088
TrEMBL
other Location (Reliability: 3)
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Westbrook, C.; Lin, Y.M.; Jarabak, J.
NADP-linked 15-hydroxyprostaglandin dehydrogenase from human placenta: partial purification and characterization of the enzyme and identification of an inhibitor in placental tissue
Biochem. Biophys. Res. Commun.
76
943-949
1977
Homo sapiens
brenda
Wong, P.Y.K.; McGiff, J.C.
Detection of 15-hydroxyprostaglandin dehydrogenase in bovine mesenteric blood vessels
Biochim. Biophys. Acta
500
436-439
1977
Bos taurus
brenda
Jarabak, J.; Fried, J.
Comparison of substrate specificities of the human placental NAD-and NADP-linked 15-hydroxyprostaglandin dehydrogenases
Prostaglandins
18
241-246
1979
Homo sapiens
brenda
Levasseur, S.; Friedman, Y.; Burke, G.
Prostaglandin metabolism in the rat adrenal cortex: Characterization of prostaglandin-9-ketoreductase and 15-hydroxyprostaglandin dehydrogenase
Biochem. Biophys. Res. Commun.
95
236-242
1980
Homo sapiens, Platyrrhini, Rattus norvegicus
brenda
Chang, D.B.G; Sun, M.; Tai, H.H.
Prostaglandin-9-ketoreductase and type II 15-hydroxyprostaglandin dehydrogenase from swine kidney are alternate activities of a single enzyme protein
Biochem. Biophys. Res. Commun.
99
745-751
1981
Homo sapiens, Sus scrofa
brenda
Tai, H.H.; Chang, D.B.G.
Purification of NADP+/NADPH-dependent 15-hydroxyprostaglandin dehydrogenase and prostaglandin 9-ketoreductase from porcine kidney
Methods Enzymol.
86
142-147
1982
Sus scrofa
brenda
Chung, H.; Fried, J.; Williams-Ashman, E.; Jarabak, J.
Glutathione mixed disulfide inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase
Prostaglandins
33
383-390
1987
Homo sapiens
brenda
Chung, H.; Harvey, R.G.; Armstrong, R.N.; Jarabak, J.
Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase
J. Biol. Chem.
262
12448-12451
1987
Homo sapiens
brenda
Wermuth, B.
NADP-dependent 15-hydroxyprostaglandin dehydrogenase is homologous to NAD-dependent 15-hydroxyprostaglandin dehydrogenase and other short-chain alcohol dehydrogenases
Prostaglandins
44
5-9
1992
Homo sapiens
brenda
Krook, M.; Ghosh, D.; Duax, W.; Jrnvall, H.
Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase)
FEBS Lett.
322
139-142
1993
Homo sapiens
brenda
Fujimori, K.; Okada, T.; Urade, Y.
Expression of NADP(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase mRNA in Monkey Ocular Tissues and Characterization of Its Recombinant Enzyme
J. Biochem.
131
383-389
2002
Macaca fascicularis (Q8MI29)
brenda
Krook, M.; Ghosh, D.; Stromberg, R.; Carlquist, M.; Jornvall, H.
Carboxyethyllysine in a protein: Native carbonyl reductase/NADP+-dependent prostaglandin dehydrogenase
Proc. Natl. Acad. Sci. USA
90
502-506
1993
Homo sapiens
brenda