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BRENDA support

Information on EC 1.1.1.413 - A-factor type gamma-butyrolactone 1'-reductase (1S-forming)

for references in articles please use BRENDA:EC1.1.1.413

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IUBMB Comments

The enzyme, which is found in bacteria that produce virginiae-butanolide (VB) type γ-butyrolactone autoregulators, reduces its substrate stereospecifically, forming a hydroxyl group in the (S) configuration.

The enzyme appears in viruses and cellular organisms

Synonyms
BARS1, Virginiae butanolide-specific dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP+ = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links