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Disease on EC 1.13.11.34 - arachidonate 5-lipoxygenase

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DISEASE
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Aberrant Crypt Foci
Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model.
Acne Vulgaris
A new concept for acne therapy: a pilot study with zileuton, an oral 5-lipoxygenase inhibitor.
Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis.
Zileuton, a new efficient and safe systemic anti-acne drug.
Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production.
Acquired Immunodeficiency Syndrome
Granulocyte-macrophage colony-stimulating factor upregulates reduced 5-lipoxygenase metabolism in peripheral blood monocytes and neutrophils in acquired immunodeficiency syndrome.
Acute Chest Syndrome
Eicosanoids in sickle cell disease: potential relevance of neutrophil leukotriene B4 to disease pathophysiology.
Acute Coronary Syndrome
A phase 2 randomized, double-blind, placebo-controlled study of the effect of VIA-2291, a 5-lipoxygenase inhibitor, on vascular inflammation in patients after an acute coronary syndrome.
Biomarkers and Bioassays for Cardiovascular Diseases: Present and Future.
Candidate genes of the 5-lipoxygenase pathway in acute coronary syndrome: a pilot study.
Effect of 5-lipoxygenase inhibitor, VIA-2291 (Atreleuton), on epicardial fat volume in patients with recent acute coronary syndrome.
Treatment with 5-Lipoxygenase Inhibitor VIA-2291 (Atreleuton) in Patients with Recent Acute Coronary Syndrome.
Acute Kidney Injury
Post-treatment effects of erythropoietin and nordihydroguaiaretic acid on recovery from cisplatin-induced acute renal failure in the rat.
Zileuton alleviates acute cisplatin nephrotoxicity: Inhibition of lipoxygenase pathway favorably modulates the renal oxidative/inflammatory/caspase-3 axis.
Acute Lung Injury
Analysis of mRNA?lncRNA and mRNA?lncRNA-pathway co?expression networks based on WGCNA in developing pediatric sepsis.
Influence of cyclooxygenase and lipoxygenase inhibitors on oxidative stress-induced lung injury.
The 5-Lipoxygenase Pathway is Required for Acute Lung Injury Following Hemorrhagic Shock.
[Protective mechanisms of sevoflurane against one-lung ventilation-induced acute lung injury: role of cyclooxygenase-2 and 5-lipoxygenase pathways].
Adenocarcinoma
5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue.
5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage.
Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model.
Effects of Celebrex and Zyflo on liver metastasis and lipidperoxidation in pancreatic cancer in Syrian hamsters.
Increased expression of the 5-lipoxygenase pathway and its cellular localization in Barrett's adenocarcinoma.
Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells.
Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells.
Novel anti-tumour activity of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4- benzoquinone (CV-6504) against established murine adenocarcinomas (MAC).
Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis.
Prognostic value of eicosanoid pathways in extrahepatic cholangiocarcinoma.
Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma.
The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis.
Adenocarcinoma, Bronchiolo-Alveolar
A genomic response of H-358 bronchiolar carcinoma cells to MK 886, an inhibitor of 5-lipoxygenase, assessed with a cDNA array.
Adenoma
Chemopreventive Efficacy and Mechanism of Licofelone in a Mouse Lung Tumor Model via Aspiration.
Common polymorphisms in 5-lipoxygenase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma.
Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking.
Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells.
Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke.
Effects of novel 5-lipoxygenase inhibitors on the incidence of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation.
Inhalation of an ethanol-based zileuton formulation provides a reduction of pulmonary adenomas in the A/J mouse model.
Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway.
Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis.
Oxylipin patterns in human colon adenomas.
The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis.
Adenomatous Polyps
Overexpression of 5-Lipoxygenase in Colon Polyps and Cancer and the Effect of 5-LOX Inhibitors In vitro and in a Murine Model.
Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis.
Adrenoleukodystrophy
Very long chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy.
Airway Obstruction
Enhanced arachidonic acid metabolism and human neutrophil migration in asthma.
The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma.
The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air.
Altitude Sickness
A new 5-lipoxygenase inhibitor seems to be safe and effective for the treatment of osteoarthritis.
The effects of a 5-lipoxygenase inhibitor on acute mountain sickness and urinary leukotriene e4 after ascent to high altitude.
Alveolar Bone Loss
The role of 5-lipoxygenase in Aggregatibacter actinomycetemcomitans-induced alveolar bone loss.
Alzheimer Disease
5-Lipoxygenase (5-LOX) promoter polymorphism in patients with early-onset and late-onset Alzheimer's disease.
5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease.
5-lipoxygenase activating protein reduction ameliorates cognitive deficit, synaptic dysfunction, and neuropathology in a mouse model of Alzheimer's disease.
5-lipoxygenase as an endogenous modulator of amyloid ? formation in vivo.
5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease.
5-Lipoxygenase gene polymorphism and onset of Alzheimer's disease.
5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease.
5-Lipoxygenase in the Prefrontal Cortex of Suicide Victims.
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
5-LOX in Alzheimer's Disease: Potential Serum Marker and In Vitro Evidences for Rescue of Neurotoxicity by Its Inhibitor YWCS.
Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice.
Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.
Corrigendum to 'Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index [Šerý et al., J. Neurol. Sci. 362 (2016) 27-32].
Cyclooxygenases and 5-lipoxygenase in Alzheimer's disease.
Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders.
Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer's Disease Pathology.
Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays.
Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease.
Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.
Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease.
Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase pathways.
Interrelationship between the 5-lipoxygenase pathway and microbial dysbiosis in the progression of Alzheimer's disease.
Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model.
Involvement of 5-lipoxygenase in Alzheimer's disease: a role for DNA methylation.
Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease.
Modulation of Amyloid-? Production by Leukotriene B4 via the ?-Secretase Pathway.
Neuroprotection of (+)-2-(1-Hydroxyl-4-Oxocyclohexyl) Ethyl Caffeate Against Hydrogen Peroxide and Lipopolysaccharide Induced Injury via Modulating Arachidonic Acid Network and p38-MAPK Signaling.
Nutraceutical Potential of Phenolics from 'Brava' and 'Mansa' Extra-Virgin Olive Oils on the Inhibition of Enzymes Associated to Neurodegenerative Disorders in Comparison with Those of 'Picual' and 'Cornicabra'.
Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an Alzheimer's Disease Transgenic Mouse Model Involvement of ?-Secretase.
Pharmacologic Inhibition of 5-Lipoxygenase Improves Memory, Rescues Synaptic Dysfunction, and Ameliorates Tau Pathology in a Transgenic Model of Tauopathy.
Role of Cyclooxygenase-2 and 5-Lipoxygenase Polymorphisms in Alzheimer's Disease in a Population from Northern Italy: Implication for Pharmacogenomics.
Role of cyclooxygenase-2 and 5-lipoxygenase polymorphisms in Alzheimer's disease in a population from northern Italy: implication for pharmacogenomics.
SAR-studies of ?-secretase modulators with PPAR?-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.
The 5-lipoxygenase (5-LOX) Inhibitor Zileuton Reduces Inflammation and Infarct Size with Improvement in Neurological Outcome Following Cerebral Ischemia.
The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer's disease phenotype.
The Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene promoter is not associated with late onset Alzheimer disease.
Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice.
Amyloidosis
Pharmacologic Inhibition of 5-Lipoxygenase Improves Memory, Rescues Synaptic Dysfunction, and Ameliorates Tau Pathology in a Transgenic Model of Tauopathy.
Anaphylaxis
2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA861), a selective inhibitor of the 5-lipoxygenase reaction and the biosynthesis of slow-reacting substance of anaphylaxis.
Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acryl amides.
Acrylamide derivatives as antiallergic agents. III. Synthesis and structure-activity relationships of N-[4-(4-diphenylmethyl-1-piperazinyl)butyl]- and N-[4-(4-diphenylmethylene-1-piperidyl)butyl]-3-heteroarylacry lamides.
Anti-inflammatory activity of the ethanol extract of Chungkukjang, Korean fermented bean: 5-lipoxygenase inhibition.
Characterization and modulation of antigen-induced effects in isolated rat heart.
Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.
Effect of 5-lipoxygenase inhibitors on the anti-IgE-induced contraction of passively sensitized human bronchus in vitro.
Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species.
Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs.
Effects of 5-lipoxygenase inhibition on cardiac anaphylaxis in isolated guinea pig hearts.
Flavonoids: potent inhibitors of arachidonate 5-lipoxygenase.
Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid.
Inhibition of leukotriene biosynthesis in the rat peritoneal cavity.
Leukotrienes in respiratory disease.
Non steroidal anti-inflammatory and anti-allergy agents.
OKY-046 prevents increases in LTB4 and pulmonary edema in phorbol ester-induced lung injury in dogs.
Predominant synthesis of 5-hydroxyeicosatetraenoic acid by a cloned mastocytoma P-815 line, 2-E-6 cells.
Role of leukotriene B4 in 5-lipoxygenase metabolite- and allergy-induced itch-associated responses in mice.
Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on bronchial anaphylaxis in anaesthetized guinea-pigs.
Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists.
Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds.
Synthesis and antiallergic activity of N-[4-(4-diphenylmethyl-1-piperazinyl)butyl]-1,4-dihydro-4-oxopyridine-3 - carboxamides.
Synthesis of trimethylhydroquinone derivatives as anti-allergic agents with anti-oxidative actions.
The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis.
[Characteristics of the antioxidant system of alveolar surfactant in immediate-type allergies]
Anemia
5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas' disease.
Aneurysm
Inhibition of 5-lipoxygenase suppresses vascular endothelial growth factor-induced angiogenesis in endothelial cells.
Smoking promotes pathogenesis of aortic aneurysm through the 5-lipoxygenase pathway.
Angina, Unstable
Increased urinary leukotriene excretion in patients with cardiac ischemia. In vivo evidence for 5-lipoxygenase activation.
Angioedema
NSAID-induced urticaria and angioedema: a reappraisal of its clinical management.
Anthrax
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
Aortic Aneurysm
A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine aortic aneurysm model.
Is there a role for the macrophage 5-lipoxygenase pathway in aortic aneurysm development in apolipoprotein E-deficient mice?
Smoking promotes pathogenesis of aortic aneurysm through the 5-lipoxygenase pathway.
The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.
Aortic Aneurysm, Abdominal
5-Lipoxygenase pathway in experimental abdominal aortic aneurysms.
Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice.
Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm.
The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysms.
Aortic Valve Stenosis
Epigenetic regulation of 5-lipoxygenase in the phenotypic plasticity of valvular interstitial cells associated with aortic valve stenosis.
Role of 5-lipoxygenase pathway in the pathophysiology of the aortic stenosis.
arachidonate 12-lipoxygenase deficiency
Altered arachidonate metabolism by leukocytes and platelets in myeloproliferative disorders.
arachidonate 5-lipoxygenase deficiency
5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.
5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury.
5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality.
5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice.
Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice.
Effects of cocaine in 5-lipoxygenase-deficient mice.
Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice.
Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice.
Inhibition of 5-lipoxygenase is associated with downregulation of the leukotriene B4 receptor 1/ Interleukin-12p35 pathway and ameliorates sepsis-induced myocardial injury.
Inhibition of 5-lipoxygenase suppresses vascular endothelial growth factor-induced angiogenesis in endothelial cells.
Arteritis
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis.
Arthritis
5-Lipoxygenase inhibitors attenuate TNF-?-induced inflammation in human synovial fibroblasts.
5-Lipoxygenase-deficient mice infected with Borrelia burgdorferi develop persistent arthritis.
Anti-inflammatory Potential of Alpha-Linolenic Acid Mediated Through Selective COX Inhibition: Computational and Experimental Data.
Computer modeling in predicting the bioactivity of human 5-lipoxygenase inhibitors.
Designing therapeutically effective 5-lipoxygenase inhibitors.
Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.
Fuscoside: an anti-inflammatory marine natural product which selectively inhibits 5-lipoxygenase. Part II: Biochemical studies in the human neutrophil.
Identification of Novel Therapeutic Molecular Targets in Inflammatory Bowel Disease by Using Genetic Databases.
In Vitro Anti-Inflammatory and In Vivo Antiarthritic Activities of Aqueous and Ethanolic Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Rats.
Inhibition by leukotriene inhibitors, and calcium and platelet-activating factor antagonists, of acute gastric and intestinal damage in arthritic rats and in cholinomimetic-treated mice.
Pro-inflammatory enzymes, cyclooxygenase 1, cyclooxygenase 2, and 5-lipooxygenase, inhibited by stabilized rice bran extracts.
Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis in rats.
Arthritis, Experimental
Antiinflammatory 2,6-di-tert-butyl-4-(2-arylethenyl)phenols.
Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis.
Effects of the second-generation leukotriene B(4) receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice.
Inhibitory effects of the root extract of Litsea cubeba (Lour.) Pers. on adjuvant arthritis in rats.
Arthritis, Gouty
Frontline Science: Reprogramming COX-2, 5-LOX, and CYP4A-mediated arachidonic acid metabolism in macrophages by salidroside alleviates gouty arthritis.
Metabolic profiling of human plasma reveals the activation of 5-lipoxygenase in the acute attack of gouty arthritis.
Arthritis, Rheumatoid
5-Lipoxygenase inhibitors attenuate TNF-?-induced inflammation in human synovial fibroblasts.
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.
Acute and chronic suppression of leukotriene B4 synthesis ex vivo in neutrophils from patients with rheumatoid arthritis beginning treatment with methotrexate.
Altered formation of leukotriene B4 in vitro by synovial fluid neutrophils in rheumatoid arthritis.
Differential synthesis of 5-lipoxygenase in peripheral blood and synovial fluid neutrophils in rheumatoid arthritis.
Effect of 5-lipoxygenase inhibition on events associated with inflammatory bowel disease in rats.
Enhanced capacity for release of leucotriene B4 by neutrophils in rheumatoid arthritis.
Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.
Inhibition of 5-lipoxygenase product formation and polymorphonuclear cell degranulation by tenidap sodium in patients with rheumatoid arthritis.
Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells.
Mechanistic insights into 5-lipoxygenase inhibition by pyocyanin: a molecular docking and molecular dynamics study.
Non steroidal anti-inflammatory and anti-allergy agents.
Population pharmacokinetics of zileution, a selective 5-lipoxygenase inhibitor, in patients with rheumatoid arthritis.
Proinflammatory lipoxygenase products from peripheral mononuclear cells in patients with rheumatoid arthritis.
Synthesis and Biological Evaluation of N-Aryl-4-Aryl-1,3-Thiazole-2-Amine Derivatives as direct 5-Lipoxygenase Inhibitors.
Synthesis and Biological Evaluation of N-Aryl-5-aryloxazol-2-amine Derivatives as 5-Lipoxygenase Inhibitors.
The effect of methotrexate on ex vivo lipoxygenase metabolism in neutrophils from patients with rheumatoid arthritis.
Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis in rats.
Zileuton, a 5-lipoxygenase inhibitor in rheumatoid arthritis.
[Leukotrienes. A review of the significance for disease in man and the possibilities for therapeutic intervention]
Aspergillosis
12/15-Lipoxygenase Deficiency Impairs Neutrophil Granulopoiesis and Lung Proinflammatory Responses to Aspergillus fumigatus.
Asthma
2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis.
2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: implications for toxicity associated with zileuton.
5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.
5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population.
5-Lipoxygenase Pathway, Dendritic Cells, and Adaptive Immunity.
5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci.
5-Lipoxygenase-deficient mice infected with Borrelia burgdorferi develop persistent arthritis.
A Cell-based Assay for Screening Lipoxygenase Inhibitors.
A new 5-lipoxygenase inhibitor seems to be safe and effective for the treatment of osteoarthritis.
A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma.
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.
A turn on and a turn off: BLT1 and BLT2 mechanisms in the lung.
ABT-761 attenuates bronchoconstriction and pulmonary inflammation in rodents.
Activity of a novel hydroquinone inhibitor of leukotriene synthesis (U-66,858) in the rhesus monkey Ascaris reactor.
Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial. Zileuton Study Group.
Allergen-stimulated leukotriene B4 and interleukin-8 levels in patients with asthma and allergic rhinitis-modulation by a lipid pathway inhibitor.
ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma.
An ex vivo model of severe asthma using reconstituted human bronchial epithelium.
Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics.
Arachidonate 5-lipoxygenase metabolism in human neutrophils from patients with asthma: in vitro effect of nedocromil sodium.
Arachidonic acid metabolites: mediators of inflammation in asthma.
Association of 5-lipoxygenase gene polymorphisms with bronchial asthma.
Bioguidage search of active compounds from Waltheria indica L. (Malvaceae) used for asthma and inflammation treatment in Burkina Faso.
Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes.
CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain.
Clinical pattern of zileuton-associated liver injury: results of a 12-month study in patients with chronic asthma.
Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors
Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors.
Comprehensive asthma management: guidelines for clinicians.
Computer modeling in predicting the bioactivity of human 5-lipoxygenase inhibitors.
Cysteinyl Leukotrienes (CysLTs): Role in Obesity-Induced Asthma.
Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation.
Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary Inflammation.
Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies.
Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase.
Designing therapeutically effective 5-lipoxygenase inhibitors.
Development of 3D-QSAR models for 5-lipoxygenase antagonists: chalcones.
Dose-proportional pharmacokinetics of a new 5-lipoxygenase inhibitor, ABT-761, in healthy volunteers.
Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.
Drugs that target lipoxygenases and leukotrienes as emerging therapies for asthma and cancer.
Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma.
Effect of 5-lipoxygenase inhibition on events associated with inflammatory bowel disease in rats.
Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients.
Effect of a novel 5-lipoxygenase activating protein inhibitor, BAYx 1005, on asthma induced by cold dry air.
Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species.
Effect of chronic 5-lipoxygenase inhibition on airway hyperresponsiveness in asthmatic subjects.
Effect of physicochemical and formulation variables on the in vivo absorption of ABT-761.
Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses.
Effect of the 5-lipoxygenase inhibitor ZD2138 on aspirin-induced asthma.
Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group.
Effect of zileuton on theophylline pharmacokinetics.
Effects of ABT-761, a novel 5-lipoxygenase inhibitor, on the pharmacokinetics of a single dose of ethinyl estradiol and levonorgestrel in healthy female volunteers.
Effects of antirheumatic drugs on leukotriene B4 and prostanoid synthesis in human polymorphonuclear leukocytes in vitro.
Effects of glucocorticoids on endogenous and transcellular metabolism of eicosanoids in asthma.
Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients.
Efficacy, safety and tolerability of GSK2190915, a 5-lipoxygenase activating protein inhibitor, in adults and adolescents with persistent asthma: a randomised dose-ranging study.
Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis.
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.
Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells.
Experimental treatments for asthma.
Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma.
Expression of COX-1, COX-2, 5-LOX and CysLT 2 in nasal polyps and bronchial tissue of patients with aspirin exacerbated airway disease.
From Molecular Docking to 3D-Quantitative Structure-Activity Relationships (3D-QSAR): Insights into the Binding Mode of 5-Lipoxygenase Inhibitors.
Functional characterization of human cysteinyl leukotriene 1 receptor gene structure.
Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis.
Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice.
Genetics and pharmacogenetics of the leukotriene pathway.
GM-CSF- and M-CSF-primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures.
Guinea pig whole blood 5-lipoxygenase assay: utility in the assessment of potential 5-lipoxygenase inhibitors.
Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma.
In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade.
In vitro allergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: inhibition of cytosolic phospholipase A2alpha overcomes the asthma-associated response.
Increased activity of 5-lipoxygenase in polymorphonuclear leukocytes from asthmatic patients.
Increased excretion of leukotriene E4 during aspirin-induced asthma.
Inhibition of 5-lipoxygenase as anti-inflammatory mode of action of Plectranthus zeylanicus Benth and chemical characterization of ingredients by a mass spectrometric approach.
Inhibition of 5-lipoxygenase suppresses vascular endothelial growth factor-induced angiogenesis in endothelial cells.
Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells.
Inhibition of leukotriene C4 and B4 generation by human eosinophils and neutrophils with the lipoxygenase pathway inhibitors U60257 and BW755C.
L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor.
Lack of cytochrome P450 1A2 interaction effect of ABT-761 on the pharmacokinetics of theophylline.
Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics.
Leukotriene inhibitors and antagonists in asthma.
Leukotriene inhibitors and non-steroidal therapies in the treatment of asthma.
Leukotriene pathway inhibitors in asthma and chronic obstructive pulmonary disease.
Leukotriene-receptor antagonists and 5-lipoxygenase inhibitors in asthma.
Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase.
Leukotrienes in respiratory disease.
Leukotrienes in the pathogenesis of asthma.
Lipoxygenase inhibitor-provoked acute asthma in a patient with asthma relieved by aspirin.
Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists.
Mechanistic insights into 5-lipoxygenase inhibition by pyocyanin: a molecular docking and molecular dynamics study.
MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: synergistic action with LY294002, an inhibitor of phosphatidylinositol 3'-kinase.
Moderating the inflammation of asthma: inhibiting the production or action of products of the 5-lipoxygenase pathway.
Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury.
New approaches to anti-inflammatory therapy for asthma.
New frontiers in asthma therapy: leukotriene receptor antagonists and 5-lipoxygenase inhibitors. Introduction.
Non steroidal anti-inflammatory and anti-allergy agents.
Novel Cytochrome P450-mediated Ring Opening of the 1,3,4-oxadiazole in Setileuton, a 5-lipoxygenase inhibitor.
Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys.
Novel polymorphism of the 5-lipoxygenase activating protein (FLAP) promoter gene associated with asthma.
Oral vs inhaled asthma therapy. Pros, cons and combinations.
Pharmaceutical analysis combined with in-silico therapeutic and toxicological profiling on zileuton and its impurities to assist in modern drug discovery.
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment.
Pharmacogenetics of the 5-lipoxygenase pathway in asthma.
Pharmacokinetics of a novel 5-lipoxygenase inhibitor (ABT-761) in pediatric patients with asthma.
Pharmacological characterization of SB 202235, a potent and selective 5-lipoxygenase inhibitor: effects in models of allergic asthma.
Pharmacologically active natural products in the defence secretion of Palembus ocularis (Tenebrionidae, Coleoptera).
Pharmacology of 4-(3-(4-(1-methyl-1H-pyrazol-5-yl) phenylthio) phenyl)-tetrahydro-2H-pyran-4-carboxamide (PF-4191834), a Novel Selective, non-redox, 5-Lipoxygenase Inhibitor Effective in Inflammation and Pain.
Pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors in the management of asthma.
Pharmacophore modeling and virtual screening for designing potential 5-Lipoxygenase inhibitors.
Platelet-activating factor antagonists: current status in asthma.
Platelet-activating factor increases leukotriene B4 release in stimulated alveolar macrophages from asthmatic patients.
Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness.
Polymorphisms in candidate asthma genes.
Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population.
Potential anti-inflammatory effects of 5-lipoxygenase inhibition--exemplified by the leukotriene synthesis inhibitor BAY X 1005.
Predictive genetic testing -- new possibilities in determination of risk of complex diseases.
Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population.
Quantitative analysis of 5-oxo-6,8,11,14-eicosatetraenoic acid by electrospray mass spectrometry using a deuterium-labeled internal standard.
Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma.
Recurrent panniculitis in a man with asthma receiving treatment with leukotriene-modifying agents.
Reversed changes of lipoxin A4 and leukotrienes in children with asthma in different severity degree.
Role of leukotrienes in asthma.
Roles of 5-lipoxygenase and cysteinyl-leukotriene type 1 receptors in the hematological response to allergen challenge and its prevention by diethylcarbamazine in a murine model of asthma.
Simulation Study of Interactions Between Two Bioactive Components from Zingiber cassumunar and 5-Lipoxygenase.
Structure and Ligand Based Drug Design Strategies in the Development of Novel 5- LOX Inhibitors.
Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity.
Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma.
Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7.
Synthesis and Biological Evaluation of N-Aryl-4-Aryl-1,3-Thiazole-2-Amine Derivatives as direct 5-Lipoxygenase Inhibitors.
Synthesis and Biological Evaluation of N-Aryl-5-aryloxazol-2-amine Derivatives as 5-Lipoxygenase Inhibitors.
Synthesis and evaluation of 5-lipoxygenase translocation inhibitors from acylnitroso hetero-Diels-Alder cycloadducts.
Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors.
Synthesis, stereochemical assignments, and biological activities of homoisoflavonoids.
Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma.
Targeting leukotriene B4 in inflammation.
The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep.
The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages.
The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease.
The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma.
The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo.
The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma.
The effects of a 5-lipoxygenase inhibitor on antigen-induced mediator release, late-phase bronchoconstriction and cellular infiltrates in primates.
The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air.
The effects of ML 3000 on antigen-induced responses in sheep.
The effects of oral Cardax (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo.
The efficacy and tolerability of MK-0633, a 5-lipoxygenase inhibitor, in chronic asthma.
The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation.
The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).
The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).
The relationship of asthma therapy and Churg-Strauss syndrome: NIH workshop summary report.
The role of 5-lipoxygenase products in preclinical models of asthma.
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
The use of 5-lipoxygenase inhibitors and leukotriene receptor antagonists in the treatment of chronic asthma.
Therapeutic advances: leukotriene antagonists for the treatment of asthma.
Treatment of chronic stable asthma with drugs active on the 5-lipoxygenase pathway.
Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators.
Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma.
Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma.
[5-lipoxygenase inhibitors in asthma therapy]
[Current opinions about asthma: genetic factors]
[New developments in asthma therapy: how do individual leukotriene antagonists work?]
[Reversed changes of the 15-lipoxygenase product lipoxin A? and the 5-lipoxygenase product leukotriene C? in children with asthma].
[The significance of leukotrienes in pathophysiology of bronchial asthma--therapy perspectives]
[The use of leukotriene receptor antagonists and 5-lipoxygenase inhibitors in bronchial asthma treatment]
Asthma, Aspirin-Induced
Effect of the 5-lipoxygenase inhibitor ZD2138 on aspirin-induced asthma.
Effects of pranlukast on aspirin-induced bronchoconstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients.
Over-expression of the LTC(4) synthase gene in mice reproduces human aspirin-induced asthma.
Asthma, Exercise-Induced
Comparative effects of long-acting beta2-agonists, leukotriene receptor antagonists, and a 5-lipoxygenase inhibitor on exercise-induced asthma.
Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor.
Astrocytoma
Expression patterns of 5-lipoxygenase in human brain with traumatic injury and astrocytoma.
Increased expression of 5-lipoxygenase in high-grade astrocytomas.
Atherosclerosis
4-Hydroxynonenal enhances CD36 expression on murine macrophages via p38 MAPK-mediated activation of 5-lipoxygenase.
5-lipoxygenase and atherosclerosis.
5-lipoxygenase as a possible biological link between depressive symptoms and atherosclerosis.
5-Lipoxygenase as a putative link between cardiovascular and psychiatric disorders.
5-Lipoxygenase Gene Variants Are Not Associated With Atherosclerosis or Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis Cohort.
5-Lipoxygenase plays a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1.
5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation.
5-lipoxygenase: regulation and possible involvement in atherosclerosis.
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.
Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice.
Anti-atherosclerotic molecules targeting oxidative stress and inflammation.
Arachidonate 5-lipoxygenase (5-LO) promoter genotype and risk of myocardial infarction: a case-control study.
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis.
Arachidonate 5-lipoxygenase variants in atherosclerosis, obesity, and bone traits.
Association between 5-lipoxygenase expression and plaque instability in humans.
Association of ALOX5AP haplotypes with susceptibility to coronary artery disease in a Chinese Han population.
Atorvastatin inhibits the 5-lipoxygenase pathway and expression of CCL3 to alleviate atherosclerotic lesions in atherosclerotic ApoE knockout mice.
Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway.
Biologic relevance of lipoxygenase isoforms in atherogenesis.
Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice.
Cyclooxygenase and 5-lipoxygenase pathways in the vessel wall: role in atherosclerosis.
Cysteinyl-leukotriene pathway as a new therapeutic target for the treatment of atherosclerosis related to obstructive sleep apnea syndrome.
Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase.
Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice.
Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.
Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice.
Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice.
Eicosanoids and Docosanoids in Plasma and Aorta of Healthy and Atherosclerotic Rabbits.
Endothelium-dependent vascular responses induced by leukotriene B4.
Evidence for Activation of Inflammatory Lipoxygenase Pathways in Visceral Adipose Tissue of Obese Zucker Rats.
Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis.
Expanding expression of the 5-lipoxygenase/leukotriene B(4) pathway in atherosclerotic lesions of diabetic patients promotes plaque instability.
Functional characterization of human cysteinyl leukotriene 1 receptor gene structure.
Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis.
GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site.
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice.
Identification of ALOX5 as a gene regulating adiposity and pancreatic function.
Inhibition of 5-lipoxygenase as anti-inflammatory mode of action of Plectranthus zeylanicus Benth and chemical characterization of ingredients by a mass spectrometric approach.
Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells.
Inhibitors of the 5-lipoxygenase pathway in atherosclerosis.
Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation.
Leukotriene B4 strongly increases monocyte chemoattractant protein-1 in human monocytes.
Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis.
Lipid metabolism: 5-lipoxygenase, 12/15-lipoxygenase, and atherogenesis.
LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-?B Pathways.
New approaches in the diagnosis of atherosclerosis and treatment of cardiovascular disease.
Novel Cytochrome P450-mediated Ring Opening of the 1,3,4-oxadiazole in Setileuton, a 5-lipoxygenase inhibitor.
Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction.
Platelet-induced growth of human fibroblasts is associated with an increased expression of 5-lipoxygenase.
Pro-inflammatory gene variants in myocardial infarction and longevity: implications for pharmacogenomics.
Promoter methylation and functional variants in arachidonate 5-lipoxygenase and forkhead box protein O1 genes associated with coronary artery disease.
Response to arachidonate 5-lipoxygenase variants in atherosclerosis, obesity, and bone traits.
Role of inflammatory responses in initiation of atherosclerosis: effects of anti-inflammatory drugs on cuff-induced leukocyte accumulation and intimal thickening of rabbit carotid artery.
Selective inhibition of leukotriene receptor BLT-2 reduces vascular oxidative stress and improves endothelial function in ApoE-/- mice.
Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7.
The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis.
The current view on the role of leukotrienes in atherogenesis.
The effects of oral Cardax (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo.
The potential link between atherosclerosis and the 5-lipoxygenase pathway: investigational agents with new implications for the cardiovascular field.
The potential role of antileukotriene drugs in atherosclerosis.
The putative role of leukotrienes in experimental atherogenesis.
[Leukotriene-lipoxygenase pathway and drug discovery]
Autoimmune Diseases
In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis.
Bacterial Infections
Exotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesis.
Blister
Increased levels of immunoreactive leukotriene B4 in blister fluids of bullous pemphigoid patients and effects of a selective 5-lipoxygenase inhibitor on experimental skin lesions.
Bone Resorption
Amino derivatives of phenyl alkyl thiophene as inhibitors of bone resorption. Structure-activity relationship.
Avian osteoclast cells are stimulated to resorb calcified matrices by and possess receptors for leukotriene B4.
Cytokines and growth factors in the regulation of bone remodeling.
Effects of 5-lipoxygenase gene disruption on inflammation, osteoclastogenesis and bone resorption in polymicrobial apical periodontitis.
Inhibition of 5-Lipoxygenase (5-Lo) Attenuates Inflammation and Bone Resorption in Lipopolysaccharide (Lps)-Induced Periodontal Disease.
Inhibition of 5-lipoxygenase attenuates inflammation and BONE resorption in lipopolysaccharide-induced periodontal disease.
Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo.
LTB4 can directly stimulate human osteoclast formation from PBMC independent of RANKL.
Staphylococcus epidermidis produces a cell-associated proteinaceous fraction which causes bone resorption by a prostanoid-independent mechanism: relevance to the treatment of infected orthopaedic implants.
The 5-lipoxygenase inhibitor BWA4C impairs osteoclastic resorption in a synchronized model of bone remodeling.
Brain Diseases
5-Lipoxygenase as an emerging target against age-related brain disorders.
Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice.
Exploring the molecular approach of COX and LOX in Alzheimer's and Parkinson's disorder.
Brain Edema
Cerebral edema induced by arachidonic acid: role of leukocytes and 5-lipoxygenase products.
Protective effect of the 5-lipoxygenase inhibitor AA-861 on cerebral edema after transient ischemia.
Role of leukocytes and 5-lipoxygenase products in induction of cerebral edema.
Brain Infarction
Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia.
Brain Injuries
A dual inhibitor of cyclooxygenase and 5-lipoxygenase protects against kainic acid-induced brain injury.
Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders.
Expression patterns of 5-lipoxygenase in human brain with traumatic injury and astrocytoma.
Integrating Network Pharmacology and Experimental Models to Investigate the Mechanism of Huanglian Jiedu Decoction on Inflammatory Injury Induced by Cerebral Ischemia.
Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats.
Minocycline inhibits 5-lipoxygenase expression and accelerates functional recovery in chronic phase of focal cerebral ischemia in rats.
Phosphorylation of 5-LOX: The Potential Set-point of Inflammation.
Spatio-temporal properties of 5-lipoxygenase expression and activation in the brain after focal cerebral ischemia in rats.
Transforming growth factor ? 1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1.
Brain Injuries, Traumatic
Expression patterns of 5-lipoxygenase in human brain with traumatic injury and astrocytoma.
Impact of 5-lipoxygenase inhibitors on the spatiotemporal distribution of inflammatory cells and neuronal COX-2 expression following experimental traumatic brain injury in rats.
Brain Ischemia
5-Lipoxygenase as an emerging target against age-related brain disorders.
5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9.
5-Lipoxygenase Inhibitor Zileuton Inhibits Neuronal Apoptosis Following Focal Cerebral Ischemia.
A comparative study on the expression of cyclooxygenase and 5-lipoxygenase during cerebral ischemia in humans.
Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation.
Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats.
Cerebral ischemia in 5-lipoxygenase knockout mice.
Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders.
Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia.
MicroRNA-193b-3p alleviates focal cerebral ischemia and reperfusion-induced injury in rats by inhibiting 5-lipoxygenase expression.
Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats.
Minocycline inhibits 5-lipoxygenase expression and accelerates functional recovery in chronic phase of focal cerebral ischemia in rats.
Protection from hypoxic and N-methyl-D-aspartate injury with azelastine, a leukotriene inhibitor.
Spatio-temporal properties of 5-lipoxygenase expression and activation in the brain after focal cerebral ischemia in rats.
The 5-lipoxygenase (5-LOX) Inhibitor Zileuton Reduces Inflammation and Infarct Size with Improvement in Neurological Outcome Following Cerebral Ischemia.
The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats.
Zileuton Reduces Inflammatory Reaction and Brain Damage Following Permanent Cerebral Ischemia in Rats.
[Expression of 5-lipoxygenase in hippocampal CA1 neuronal damage following global cerebral ischemia in rats].
[Nordihydroguaiaretic acid partially inhibits inflammatory responses after focal cerebral ischemia in rats.]
Brain Neoplasms
A Hydroquinone-Based Derivative Elicits Apoptosis and Autophagy via Activating a ROS-Dependent Unfolded Protein Response in Human Glioblastoma.
Cytoplasmic 5-Lipoxygenase Staining Is a Highly Sensitive Marker of Human Tumors of the Choroid Plexus.
Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family.
The effect of 5-lipoxygenase inhibition on blood-brain barrier permeability in experimental brain tumors.
Breast Neoplasms
5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic Acid, and risk for breast cancer.
Aberrant expression of 5-lipoxygenase-activating protein (5-LOXAP) has prognostic and survival significance in patients with breast cancer.
Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein.
Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A(2) and 5-lipoxygenase catalyzed pathway.
Cancer-Produced Metabolites of 5-Lipoxygenase Induce Tumor-Evoked Regulatory B Cells via Peroxisome Proliferator-Activated Receptor ?.
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.
Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions.
Human cytomegalovirus infection is correlated with enhanced cyclooxygenase-2 and 5-lipoxygenase protein expression in breast cancer.
Influence of 5-lipoxygenase on in vitro growth of human mammary carcinoma cell line MCF-7.
Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition.
Serum 5-LOX: a progressive protein marker for breast cancer and new approach for therapeutic target.
Tepoxalin increases chemotherapy efficacy in drug-resistant breast cancer cells overexpressing the multidrug transporter gene ABCB1.
The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells.
Bronchial Spasm
Effect of a novel 5-lipoxygenase inhibitor, E6080 on bronchospasm, airway cellular infiltration and leukotriene production in guinea pigs.
Effect of the 5-lipoxygenase inhibitor ZD2138 on aspirin-induced asthma.
Generation of leukotrienes in guinea-pigs in vivo during antigen-induced bronchospasm.
Guinea pig whole blood 5-lipoxygenase assay: utility in the assessment of potential 5-lipoxygenase inhibitors.
Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists.
Synthesis of [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors.
The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic bronchospasm in guinea pigs.
[5-lipoxygenase inhibitors in asthma therapy]
Bronchiectasis
The detection of 5-lipoxygenase and cyclo-oxygenase products in sputum of patients with chronic bronchitis and bronchiectasis.
Bronchitis
Frankincense--therapeutic properties.
Bronchitis, Chronic
15(S)-HETE modulates LTB(4) production and neutrophil chemotaxis in chronic bronchitis.
The detection of 5-lipoxygenase and cyclo-oxygenase products in sputum of patients with chronic bronchitis and bronchiectasis.
Bronchopneumonia
5-lipoxygenase and cyclooxygenase-2 in porcine parasitic bronchopneumonia: immunohistochemical and biochemical investigations.
Burkitt Lymphoma
B-lymphocytic cell line Raji expresses the leukotriene A4 hydrolase gene but not the 5-lipoxygenase gene.
Capillary Leak Syndrome
Production of 5-lipoxygenase pathway metabolites by peripheral leucocytes in capillary leak syndrome (Clarkson disease).
Carcinogenesis
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth.
5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic Acid, and risk for breast cancer.
5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines.
5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis.
Antitumor Activities of Ethyl Acetate Extracts from Selaginella doederleinii Hieron In Vitro and In Vivo and Its Possible Mechanism.
Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein.
Chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., induces apoptosis in COLO-205 cell line.
Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol.
Co-expression of COX-2 and 5-LO in primary glioblastoma is associated with poor prognosis.
Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking.
Correlative study of microvessel density and 5-lipoxygenase expression in human sporadic colorectal cancer.
Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway.
Cysteinyl Leukotriene Receptor Antagonists Inhibit Migration, Invasion, and Expression of MMP-2/9 in Human Glioblastoma.
Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke.
Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers.
Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism.
Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemoprevention.
Human cytomegalovirus infection is correlated with enhanced cyclooxygenase-2 and 5-lipoxygenase protein expression in breast cancer.
Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol.
Increased expression of 5-lipoxygenase in high-grade astrocytomas.
Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma.
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.
Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors.
Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway.
Lipoxygenase metabolism: roles in tumor progression and survival.
Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.
MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation.
Modulation by Licofelone and Celecoxib of Experimentally Induced Cancer and Preneoplastic Lesions in Mice Exposed to Cigarette Smoke.
Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.
Overexpression of 5-lipoxygenase and its relation with cell proliferation and angiogenesis in 7,12-dimethylbenz(?)anthracene-induced rat mammary carcinogenesis.
Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis.
Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis.
Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells.
Role of 5-lipoxygenase in resveratrol mediated suppression of 7,12-dimethylbenz(?)anthracene-induced mammary carcinogenesis in rats.
Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines.
The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons.
The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis.
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis.
Time-selective chemoprevention of vitamin E and selenium on esophageal carcinogenesis in rats: The possible role of nuclear factor kappaB signaling pathway.
Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation.
Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model.
[Protein expression of 5-lipoxygenase and activation and cytotoxicity of benzidine in human bronchial epithelial cells.]
Carcinoma
15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary.
5-lipoxygenase expression and tepoxalin-induced cell death in squamous cell carcinomas in cats.
5-Lipoxygenase expression in benign and malignant canine prostate tissues.
5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway.
5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells.
Association between 5-lipoxygenase expression, and malignant behaviors and poor prognosis in esophageal squamous cell carcinoma.
Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas.
Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma.
Fatty acid oxidation and signaling in apoptosis.
Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol.
Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma.
Influence of 5-lipoxygenase on in vitro growth of human mammary carcinoma cell line MCF-7.
Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway.
Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals.
Topical chemoprevention of skin cancer in mice, using combined inhibitors of 5-lipoxygenase and cyclo-oxygenase-2.
Wedelolactone induces growth of breast cancer cells by stimulation of estrogen receptor signalling.
Carcinoma in Situ
Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma.
Carcinoma, Hepatocellular
5-Lipoxygenase contributes to the progression of hepatocellular carcinoma.
A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase.
A mutant of hepatitis B virus X protein (HBx Delta 127) enhances hepatoma cell migration via osteopontin involving 5-lipoxygenase.
Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-?B in hepatoma cells.
Carcinoma, Renal Cell
5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway.
Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
5-lipoxygenase expression and tepoxalin-induced cell death in squamous cell carcinomas in cats.
5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells.
Cardiomyopathies
Inhibition of 5-lipoxygenase is associated with downregulation of the leukotriene B4 receptor 1/ Interleukin-12p35 pathway and ameliorates sepsis-induced myocardial injury.
Cardiovascular Diseases
A Cell-based Assay for Screening Lipoxygenase Inhibitors.
ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation.
ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance.
Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice.
Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy african americans.
Common Polymorphisms in the 5-Lipoxygenase Pathway and Risk of Incident Myocardial Infarction: A Danish Case-Cohort Study.
Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.
Depression, inflammation, and cardiovascular disease: is 5-lipoxygenase the missing link?
Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers.
Functional Analysis of 5-Lipoxygenase Promoter Repeat Variants.
Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice.
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.
Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity.
Hemolytic and sphingomyelinase activities of Clostridium perfringens alpha-toxin are dependent on a domain homologous to that of an enzyme from the human arachidonic acid pathway.
Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).
Inhibitors of the 5-lipoxygenase pathway in atherosclerosis.
Metabolism of 5-hydroxy-6,8,11,14-eicosatetraenoic acid by human endothelial cells.
MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation.
Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury.
Oxidative enzymopathies and vascular disease.
Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5.
Polymorphism of SG13S114T/A in the ALOX5AP gene and the risk for stroke in a large Chinese cohort.
Predictive genetic testing -- new possibilities in determination of risk of complex diseases.
Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7.
The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).
Carotid Artery Diseases
Association of Sp1 tandem repeat polymorphism of ALOX5 with coronary artery disease in Indian subjects.
Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis.
Cataract
Lens cholesterol biosynthesis inhibition: A common mechanism of cataract formation in laboratory animals by pharmaceutical products.
Central Nervous System Diseases
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders.
Cerebral Infarction
5-LOX Inhibitor Zileuton Reduces Inflammatory Reaction and Ischemic Brain Damage Through the Activation of PI3K/Akt Signaling Pathway.
Cerebrovascular Disorders
PDE4D and ALOX5AP genetic variants and risk for Ischemic Cerebrovascular Disease in Sweden.
Chagas Cardiomyopathy
Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy.
Chagas Disease
5-Lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi infection.
5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas' disease.
Differences in cNOS/iNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice.
Trypanosoma cruzi: Effect of the absence of 5-lipoxygenase (5-LO)-derived leukotrienes on levels of cytokines, nitric oxide and iNOS expression in cardiac tissue in the acute phase of infection in mice.
Cholangiocarcinoma
CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma via 5-lipoxygenase.
Oxidative stress-mediated mouse liver lesions caused by Clonorchis sinensis infection.
Prognostic value of eicosanoid pathways in extrahepatic cholangiocarcinoma.
Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway.
Chronic Urticaria
Is there a role for antileukotrienes in urticaria?
Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review.
Coccidiosis
Dietary fish oil or lofrin, a 5-lipoxygenase inhibitor, decrease the growth-suppressing effects of coccidiosis in broiler chicks.
Coinfection
Coupling of recombinant 5-lipoxygenase and leukotriene A4 hydrolase activities and transcellular metabolism of leukotriene A4 in Sf9 insect cells.
Colitis
5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration.
5-lipoxygenase modulates the alteration of paracellular barrier function in mice ileum during experimental colitis.
Acute effects of the cys-leukotriene-1 receptor antagonist, montelukast, on experimental colitis in rats.
Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti-inflammatory molecule PH46A.
Effect of 5-lipoxygenase inhibition on events associated with inflammatory bowel disease in rats.
Effects of cyclooxygenase and lipoxygenase inhibition on eicosanoids and healing of acetic acid colitis in rats.
Effects of zileuton, a new 5-lipoxygenase inhibitor, in experimentally induced colitis in rats.
Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis.
Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease.
Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis.
The efficacy of BAY y 1015 in dextran sulfate model of mouse colitis.
Colitis, Ulcerative
4-Aminosalicylic acid, in contrast to 5-aminosalicylic acid, has no effect on arachidonic acid metabolism in human neutrophils, or on the free radical 1,1-diphenyl-2-picrylhydrazyl.
A trial of zileuton versus mesalazine or placebo in the maintenance of remission of ulcerative colitis. The European Zileuton Study Group For Ulcerative Colitis.
Altered leukotriene B4 metabolism in colonic mucosa with inflammatory bowel disease.
Blockade of leukotriene production by a single oral dose of MK-0591 in active ulcerative colitis.
Colonic expression of leukotriene-pathway enzymes in inflammatory bowel diseases.
Colorectal leukotriene B4 synthesis in vitro in inflammatory bowel disease: inhibition by the selective 5-lipoxygenase inhibitor BWA4C.
Effects of ropivacaine on eicosanoid release from human granulocytes and endothelial cells in vitro.
Frankincense--therapeutic properties.
Phase II study of the safety and efficacy of a 5-lipoxygenase inhibitor in patients with ulcerative colitis.
Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis.
Selective 5-lipoxygenase inhibition in ulcerative colitis.
Selective blockade of leukotriene production by a single dose of the FPL 64170XX 0.5% enema in active ulcerative colitis.
Verapamil inhibits in-vitro leucotriene B4 release by rectal mucosa in active ulcerative colitis.
Colonic Neoplasms
A mechanistic study of colon cancer growth promoted by cigarette smoke extract.
Altered eicosanoid levels in human colon cancer.
Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention.
Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking.
Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells.
Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke.
Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro.
Genetic deletion of 5-lipoxygenase increases tumor-infiltrating macrophages in Apc(?468) mice.
Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells.
Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.
Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin.
Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells.
Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities.
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
Overexpression of 5-Lipoxygenase in Colon Polyps and Cancer and the Effect of 5-LOX Inhibitors In vitro and in a Murine Model.
Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps.
Smoking promotes pathogenesis of aortic aneurysm through the 5-lipoxygenase pathway.
The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons.
The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.
The modulating role of nuclear factor-kappaB in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Vitamin E metabolite 13'-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice.
Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation.
Colorectal Neoplasms
5-Lipoxygenase Antagonist therapy: a new approach towards targeted cancer chemotherapy.
5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage.
Correlative study of microvessel density and 5-lipoxygenase expression in human sporadic colorectal cancer.
Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells.
Discovery of small molecule acting as multitarget inhibitor of colorectal cancer by simultaneous blocking of the key COX-2, 5-LOX and PIM-1 kinase enzymes.
Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro.
Expression of 5-lipoxygenase by human colorectal carcinoma Caco-2 cells during butyrate-induced cell differentiation.
Expression of 5-lipoxygenase in human colorectal cancer.
Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells.
Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer.
Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities.
Overexpression of 5-Lipoxygenase in Colon Polyps and Cancer and the Effect of 5-LOX Inhibitors In vitro and in a Murine Model.
Study of the polymorphisms of cyclooxygenase-2 (-765G>C) and 5-lipoxygenase (1708G>A) in patients with colorectal cancer.
TEMPORARY REMOVAL: Inhibition of COX-2 and 5-LOX regulates the progression of colorectal cancer by promoting PTEN and suppressing PI3K/AKT pathway.
The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons.
Conjunctivitis, Allergic
5-Lipoxygenase inhibitors and allergic conjunctivitis reactions in the guinea-pig.
Contracture
Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum.
Coronary Artery Disease
A new 5-lipoxygenase inhibitor seems to be safe and effective for the treatment of osteoarthritis.
Association of ALOX5AP with ischemic stroke in eastern Chinese.
Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population.
Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.
Promoter methylation and functional variants in arachidonate 5-lipoxygenase and forkhead box protein O1 genes associated with coronary artery disease.
Coronary Disease
5-Lipoxygenase Gene Variants Are Not Associated With Atherosclerosis or Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis Cohort.
The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease.
Coronary Occlusion
Protective effects of a thromboxane synthetase inhibitor, a thromboxane antagonist, a lipoxygenase inhibitor and a leukotriene C4, D4 antagonist on myocardial injury caused by acute myocardial infarction in the canine heart.
Coronavirus Infections
Targeting cyclooxygenase enzyme for the adjuvant COVID-19 therapy.
COVID-19
The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications.
Craniocerebral Trauma
The mixed lipoxygenase/cyclooxygenase inhibitor SK&F 105809 reduces cerebral edema after closed head injury in rat.
Crohn Disease
Regulated spatial distribution of cyclooxygenases and lipoxygenases in Crohn's ulcer.
Cystic Fibrosis
Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis.
Omega-3 fatty acids suppress the enhanced production of 5-lipoxygenase products from polymorph neutrophil granulocytes in cystic fibrosis.
Sputum tumour necrosis factor-alpha and leukotriene concentrations in cystic fibrosis.
[Eicosanoid metabolism in peripheral blood cells in patients with cystic fibrosis]
Cystitis
Lipoxygenase-5 Expression in Canine Urinary Bladder: Normal Urothelium, Cystitis and Transitional Cell Carcinoma.
Cytomegalovirus Infections
Evidence of human cytomegalovirus infection and expression of 5-lipoxygenase in borderline ovarian tumors.
Human cytomegalovirus infection induces leukotriene B4 and 5-lipoxygenase expression in human placentae and umbilical vein endothelial cells.
Human cytomegalovirus infection is correlated with enhanced cyclooxygenase-2 and 5-lipoxygenase protein expression in breast cancer.
Dehydration
Eosinophil 15-lipoxygenase is a leukotriene A4 synthase.
Demyelinating Diseases
Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage.
Toxic peripheral neuropathy with demyelination in Sprague-Dawley rats given CGS 21595--a 5-lipoxygenase inhibitor.
Dengue
Augmentation of 5-lipoxygenase activity and expression during dengue serotype-2 infection.
Dermatitis
Conjugated linoleic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice through dual inhibition of COX-2/5-LOX and TLR4/NF-?B signaling.
Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice.
Dermatitis, Atopic
Double-blinded, placebo-controlled, cross-over pilot study on the efficacy of zileuton for canine atopic dermatitis.
Inhibition of Experimental Atopic Dermatitis by Rhubarb (Rhizomes of Rheum tanguticum) and 5-Lipoxygenase Inhibition of its Major Constituent, Emodin.
Involvement of leukotriene B(4) in spontaneous itch-related behaviour in NC mice with atopic dermatitis-like skin lesions.
Leukotrienes in atopic eczema.
Dermatitis, Contact
Involvement of arachidonate-dependent lipid mediators and platelet-activating factor in experimental murine contact dermatitis.
Leukotriene B?-leukotriene B? receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8? T cells.
Phytochemical and biological studies of bryophytes.
Dermatomyositis
The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis.
Diabetes Mellitus
Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays.
Targeted deep resequencing of ALOX5 and ALOX5AP in patients with diabetes and association of rare variants with leukotriene pathways.
Diabetes Mellitus, Type 1
Impaired wound healing in type 1 diabetes is dependent on 5-lipoxygenase products.
Diabetes Mellitus, Type 2
5-Lipoxygenase (ALOX5): Genetic susceptibility to type 2 diabetes and vitamin D effects on monocytes.
Exploring N1-p-Fluorobenzyl-Cymserine as an Inhibitor of 5-Lipoxygenase as a Candidate for Type 2 Diabetes and Neurodegenerative Disorder Treatment.
Increased PUFA Content and 5-Lipoxygenase Pathway Expression Are Associated with Subcutaneous Adipose Tissue Inflammation in Obese Women with Type 2 Diabetes.
Regulation of oxidative stress and inflammation by glycaemic control: evidence for reversible activation of the 5-lipoxygenase pathway in type 1, but not in type 2 diabetes.
Targeted deep resequencing of ALOX5 and ALOX5AP in patients with diabetes and association of rare variants with leukotriene pathways.
Diabetic Retinopathy
5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.
Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy.
Dyspnea
Inhibition of allergen-induced bronchoconstriction in hyperreactive rats as a model for testing 5-lipoxygenase inhibitors and leukotriene D4 receptor antagonists.
L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor.
Embolic Stroke
Early and Sustained Increases in Leukotriene B4 Levels Are Associated with Poor Clinical Outcome in Ischemic Stroke Patients.
Encephalitis
LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii.
Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats.
Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase.
SAR-studies of ?-secretase modulators with PPAR?-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.
Western blot expression of 5-lipoxygenase in the brain from striped dolphins (stenella coeruleoalba) and bottlenose dolphins (tursiops truncatus) with or without encephalitis/meningo-encephalitis of infectious nature.
Encephalomyelitis
Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes.
Suppression of active but not passive autoimmune encephalomyelitis by dual cyclo-oxygenase and 5-lipoxygenase inhibition.
Suppression of experimental autoimmune encephalomyelitis by dual cyclo-oxygenase and 5-lipoxygenase inhibition.
Suppression of experimental autoimmune encephalomyelitis by sulfasalazine.
Encephalomyelitis, Autoimmune, Experimental
Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase.
Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes.
Suppression of active but not passive autoimmune encephalomyelitis by dual cyclo-oxygenase and 5-lipoxygenase inhibition.
Suppression of experimental autoimmune encephalomyelitis by dual cyclo-oxygenase and 5-lipoxygenase inhibition.
Suppression of experimental autoimmune encephalomyelitis by sulfasalazine.
Endometrial Neoplasms
Integrated eicosanoid lipidomics and gene expression reveal decreased prostaglandin catabolism and increased 5-lipoxygenase expression in aggressive subtypes of endometrial cancer.
The Role of Eicosanoids in Gynecological Malignancies.
Endotoxemia
5-lipoxygenase inhibitor (AA-861) attenuates neutrophil-mediated oxidative stress on the venular endothelium in endotoxemia.
Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice.
Effect of 5-lipoxygenase inhibitor against lipopolysaccharide-induced hypothermia in mice.
Effect of a 5-lipoxygenase inhibitor on endotoxin-induced pulmonary dysfunction in awake sheep.
Effect of inhibition of 5-lipoxygenase metabolism of arachidonic acid on response to endotoxemia in sheep.
Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.
Role of TLR-4 in liver macrophage and endothelial cell responsiveness during acute endotoxemia.
Eosinophilia
5-lipoxygenase- and Glucocorticoid-dependent eosinophilia in a novel surgical model in mice.
A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats.
Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice.
Comparison of 5- and 15-lipoxygenase activities in blood and alveolar leukocyte preparations from normal subjects and patients with eosinophilia.
Leukotriene enhanced allergic lung inflammation through induction of chemokine production.
Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13.
Epilepsy
Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders.
Erythema
Double-blinded, placebo-controlled, cross-over pilot study on the efficacy of zileuton for canine atopic dermatitis.
Esophageal Neoplasms
5-Lipoxygenase contributes to the progression of hepatocellular carcinoma.
Increased 5-lipoxygenase expression and induction of apoptosis by its inhibitors in esophageal cancer: a potential target for prevention.
The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Association between 5-lipoxygenase expression, and malignant behaviors and poor prognosis in esophageal squamous cell carcinoma.
Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma.
Familial Primary Pulmonary Hypertension
5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension.
5-Lipoxygenase and human pulmonary artery endothelial cell proliferation.
Fatty Liver
Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice.
Fibrosarcoma
In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase.
Gallstones
A novel 5-lipoxygenase inhibitor prevents gallstone formation in a lithogenic prairie dog model.
Gastritis
The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis.
Gastrointestinal Neoplasms
Prevention of cancer in the upper gastrointestinal tract with COX-inhibition. Still an option?
Giant Cell Tumors
5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices.
Glioblastoma
Co-expression of COX-2 and 5-LO in primary glioblastoma is associated with poor prognosis.
Down-regulation of vinculin upon MK886-induced apoptosis in LN18 glioblastoma cells.
Increased expression of 5-lipoxygenase in glioblastoma multiforme.
Kukoamine A inhibits human glioblastoma cell growth and migration through apoptosis induction and epithelial-mesenchymal transition attenuation.
NMR metabolomics analysis of the effects of 5-lipoxygenase inhibitors on metabolism in glioblastomas.
The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells.
Glioma
5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid.
5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines.
A Hydroquinone-Based Derivative Elicits Apoptosis and Autophagy via Activating a ROS-Dependent Unfolded Protein Response in Human Glioblastoma.
An Inhibitor of Arachidonate 5-Lipoxygenase, Nordy, Induces Differentiation and Inhibits Self-Renewal of Glioma Stem-Like Cells.
Augmentation of chemotherapy-triggered glioma cell apoptosis by blockade of arachidonic acid metabolism-the potential role of ceramide accumulation.
Effects of the 5-lipoxygenase inhibitors AA-863 and U-60,257 on human glioma cell lines.
Leukotriene and 5-lipoxygenase inhibitor induced variations in thymidine uptake in a human glioma cell line cultured as monolayers or as multicellular spheroids.
Modulation of glioma cell growth and 5-lipoxygenase expression by interferon.
Glomerulonephritis
Arachidonate and renal function.
Effect of thromboxane A2 inhibition and antagonism on prostaglandin and leukotriene synthesis in glomerular immune injury.
Expression of 5-lipoxygenase and 5-lipoxygenase activation protein in glomerulonephritis.
Five-lipoxygenase products in glomerular immune injury.
Gene expression of 5-lipoxygenase and LTA4 hydrolase in renal tissue of nephrotic syndrome patients.
Leukotrienes and lipoxins: lipoxygenase-derived modulators of leukocyte recruitment and vascular tone in glomerulonephritis.
Licofelone inhibits interleukin-18-induced pro-inflammatory cytokine release and cellular proliferation in human mesangial cells.
Role of leukotrienes and lipoxygenases in glomerular injury.
Selective inhibition of 5-lipoxygenase attenuates glomerulonephritis in the rat.
Glomerulonephritis, IGA
Expression of 5-lipoxygenase and 5-lipoxygenase activation protein in glomerulonephritis.
Gout
Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.
NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout.
[Inhibiting cyclooxygenase and 5-lipoxygenase activities is an anti-inflammatory mechanism of Huzhang Gout Granule.]
Graft vs Host Disease
Inhibition of 5-lipoxygenase alleviates graft-versus-host disease.
Granuloma
5-lipoxygenase pathway is essential for the control of granuloma extension induced by Schistosoma mansoni eggs in lung.
Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni.
The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis.
Granuloma Annulare
Treatment of disseminated granuloma annulare with a 5-lipoxygenase inhibitor and vitamin E.
Granulomatous Disease, Chronic
Toxoplasma gondii alters eicosanoid release by human mononuclear phagocytes: role of leukotrienes in interferon gamma-induced antitoxoplasma activity.
Head and Neck Neoplasms
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Hepatitis B
A mutant of hepatitis B virus X protein (HBx Delta 127) enhances hepatoma cell migration via osteopontin involving 5-lipoxygenase.
A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase.
Hepatitis B Virus X Protein Drives Multiple Cross-Talk Cascade Loops Involving NF-?B, 5-LOX, OPN and Capn4 to Promote Cell Migration.
Hepatitis C
Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.
Histoplasmosis
5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.
Hyperalgesia
Analgetic activity of SK&F 105809, a dual inhibitor of arachidonic acid metabolism.
Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat.
Effect of a 5-lipoxygenase inhibitor on nerve growth factor-induced thermal hyperalgesia in the rat.
Effect of licofelone against mechanical hyperalgesia and cold allodynia in the rat model of incisional pain.
Effect of zileuton in radicular pain induced by herniated nucleus pulposus in rats.
L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor.
Nerve growth factor induced hyperalgesia in the rat hind paw is dependent on circulating neutrophils.
Paulistine-The Functional Duality of a Wasp Venom Peptide Toxin.
Pharmacological evidence for a role of lipoxygenase products in platelet-activating factor (PAF)-induced hyperalgesia.
Pharmacological modulation of eicosanoid levels and hyperalgesia in yeast-induced inflammation.
Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors.
Hypercholesterolemia
Hypercholesterolemia increases the production of leukotriene B4 in neutrophils by enhancing the nuclear localization of 5-lipoxygenase.
Pharmacological properties of marine macroalgae-associated heterotrophic bacteria.
Hyperlipoproteinemia Type II
5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia.
Hypersensitivity
5-lipoxygenase expression and activity in aorta from streptozotocin-induced diabetic rats.
A Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitor AM679 Reduces Inflammation in the RSV-Infected Mouse Eye.
Antileukotrienes in clinical development for asthma.
Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.
Development of 5-lipoxygenase inhibitors--lessons from cellular enzyme regulation.
Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species.
Enhanced production of LTB4 and free radicals in rat lung by exhaustive physical exercise.
Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase[sol ]cyclooxygenase.
Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenase.
MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation.
Molecular characterization of EP6--a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor.
Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.
Potential anti-inflammatory effects of 5-lipoxygenase inhibition--exemplified by the leukotriene synthesis inhibitor BAY X 1005.
Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor.
Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors.
TGF?/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation.
The use of leukotriene D4 receptor antagonists and 5-lipoxygenase inhibitors to define a role for leukotrienes in allergic reactions.
[Effects of alminoprofen on the allergic reactions]
Hypersensitivity, Delayed
Effects of cyclooxygenase and lipoxygenase inhibitors on inflammation associated with oxazolone-induced delayed hypersensitivity.
Hypersensitivity, Immediate
2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis.
5-Lipoxygenase inhibitors and allergic conjunctivitis reactions in the guinea-pig.
Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5- benzofuranol, a potent topical antiinflammatory agent.
Effects of a 5-lipoxygenase inhibitor (L-651,392) and leukotriene D4 antagonist (L-649,923) in two animal models of immediate hypersensitivity reactions.
Non steroidal anti-inflammatory and anti-allergy agents.
Hypertension
A new treatment for severe pulmonary arterial hypertension based on an old idea: inhibition of 5-lipoxygenase.
Effect of 5-lipoxygenase and cyclooxygenase blockade on porcine hemodynamics during continuous infusion of platelet-activating factor.
HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension.
Pharmacological properties of marine macroalgae-associated heterotrophic bacteria.
Hypertension, Pregnancy-Induced
Cyclooxygenase gene expression in human endometrium and decidua.
Hypertension, Pulmonary
Contractile actions of endothelin-1 in isolated helical strips from rat pulmonary artery: potentiation of serotonin-induced contraction.
Delayed thromboxane or tumor necrosis factor-alpha, but not leukotriene inhibition, attenuates prolonged pulmonary hypertension in endotoxemia.
Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats.
Expression of 5-lipoxygenase in pulmonary artery endothelial cells.
Prolonged pulmonary hypertension caused by platelet-activating factor and leukotriene C4 in the rat lung.
Hyperventilation
Effect of a novel 5-lipoxygenase activating protein inhibitor, BAYx 1005, on asthma induced by cold dry air.
The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air.
Hypotension
Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model.
Idiopathic Pulmonary Fibrosis
Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis.
Ileitis
The role of leukotriene B4 in Clostridium difficile toxin A-induced ileitis in rats.
Immune System Diseases
Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles.
Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis.
Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.
Regulation of the 5-lipoxygenase pathway in human leucocytes.
Infarction, Middle Cerebral Artery
Lipoxin a(4) inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury.
Metabolic changes of arachidonic acid after cerebral ischemia-reperfusion in diabetic rats.
Spatio-temporal properties of 5-lipoxygenase expression and activation in the brain after focal cerebral ischemia in rats.
Infections
5-Lipoxygenase Activity Increases Susceptibility to Experimental Paracoccidioides brasiliensis Infection.
5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.
5-Lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi infection.
5-Lipoxygenase Negatively Regulates Th1 Response during Brucella abortus Infection in Mice.
5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas' disease.
5-LOX inhibitor modulates the inflammatory responses provoked by Helicobacter pylori infection.
Augmentation of 5-lipoxygenase activity and expression during dengue serotype-2 infection.
Changes in Caenorhabditis elegans immunity and Staphylococcal virulence factors during their interactions.
Concurrent Control of KSHV Life Cycle through Chromatin Modulation and Host Hedgehog Signaling: A New Prospect to the Therapeutic Potential of Lipoxin A4.
Differences in cNOS/iNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice.
Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection.
Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase.
Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells.
In vivo generation of 5-lipoxygenase products in frogs and toads.
Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells.
Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes.
Leukotriene B4 protects latently infected mice against murine cytomegalovirus reactivation following allogeneic transplantation.
Leukotriene B4 receptor BLT1 signaling is critical for neutrophil apoptosis and resolution of experimental Lyme arthritis.
Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities.
Leukotrienes play a role in the control of parasite burden in murine strongyloidiasis.
Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation.
Lipoxin A4 impairs effective bacterial control and potentiates joint inflammation and damage caused by Staphylococcus aureus infection.
Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni.
Pasteurella haemolytica leukotoxin enhances production of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by bovine polymorphonuclear leukocytes.
Pivotal Role of 5-Lipoxygenase Pathway in Lung Injury After Experimental Sepsis.
Respiratory syncytial virus induces the expression of 5-lipoxygenase and endothelin-1 in bronchial epithelial cells.
Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects.
Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology.
The Pivotal Role of 5-Lipoxygenase-Derived LTB4 in Controlling Pulmonary Paracoccidioidomycosis.
The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications.
Toxoplasma gondii Soluble Tachyzoite Antigen Triggers Protective Mechanisms against Fatal Intestinal Pathology in Oral Infection of C57BL/6 Mice.
Trypanosoma cruzi: Effect of the absence of 5-lipoxygenase (5-LO)-derived leukotrienes on levels of cytokines, nitric oxide and iNOS expression in cardiac tissue in the acute phase of infection in mice.
Inflammatory Bowel Diseases
5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability.
5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease.
5-Lipoxygenase inhibitors in the treatment of inflammatory bowel disease.
5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration.
5-lipoxygenase modulates the alteration of paracellular barrier function in mice ileum during experimental colitis.
Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase.
Colonic expression of leukotriene-pathway enzymes in inflammatory bowel diseases.
Colorectal leukotriene B4 synthesis in vitro in inflammatory bowel disease: inhibition by the selective 5-lipoxygenase inhibitor BWA4C.
Effect of 5-lipoxygenase inhibition on events associated with inflammatory bowel disease in rats.
Expression of 5-lipoxygenase mRNA is unchanged in the colon of patients with active inflammatory bowel disease.
In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production.
Possible mode of action of 5-aminosalicylic acid.
Sulphasalazine fails to prevent development of mucosal ulceration and 5-lipoxygenase activity in guinea-pigs with chronic inflammatory bowel disease induced by combined bacterial immunization and oral carrageenin.
The role of leukotriene antagonists and inhibitors in the treatment of airway disease.
Treatment of inflammatory bowel disease from now to the millennium.
Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis.
[Benzoxazole Derivative B-98 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis and the Change of T Cell Profiles in Acute Murine Colitis Model].
[Leukotrienes. A review of the significance for disease in man and the possibilities for therapeutic intervention]
Influenza, Human
Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.
Induction of a 5-lipoxygenase product by daidzein is involved in the regulation of influenza virus replication.
Insulin Resistance
5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes.
A role for 5-lipoxygenase products in obesity-associated inflammation and insulin resistance.
Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice.
Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice.
Intestinal Polyposis
Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.
Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation.
Iron Overload
Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation.
Irritable Bowel Syndrome
Frankincense--therapeutic properties.
Ischemic Stroke
Advances in the genetic basis of coronary artery disease.
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene rs4073259 polymorphism not associated with ischemic stroke in the Northeastern Chinese Han population(?).
Association of ALOX5, LTA4H and LTC4S gene polymorphisms with ischemic stroke risk in a cohort of Chinese in east China.
Association of ALOX5AP with ischemic stroke: a population-based case-control study.
Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischaemic stroke.
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.
Genetics of ischemic stroke.
Ischaemic stroke in hypertensive patients is associated with variations in the PDE4D genome region.
Ischemic stroke risk in a southeastern Chinese population: Insights from 5-lipoxygenase activating protein and phosphodiesterase 4D single-nucleotide polymorphisms.
Phosphodiesterase 4D and 5-lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians.
Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke.
The 5-lipoxygenase (5-LOX) Inhibitor Zileuton Reduces Inflammation and Infarct Size with Improvement in Neurological Outcome Following Cerebral Ischemia.
Three polymorphisms of ALOX5AP and risk of ischemic stroke in Chinese: evidence from a meta-analysis.
Traditional Chinese medicine, a solution for reducing dual stroke risk factors at once?
Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
Joint Diseases
Lipoxygenase products in inflammatory synovial fluids and other exudates.
Kidney Diseases
Fish oil feeding modulates leukotriene production in murine lupus nephritis.
Kidney Failure, Chronic
5-Lipoxygenase-mediated mitochondrial damage and apoptosis of mononuclear cells in ESRD patients.
N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity.
Kidney Neoplasms
Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.
Leishmaniasis
Arachidonic acid metabolism in murine leishmaniasis (Donovani): ex-vivo evidence for increased cyclooxygenase and 5-lipoxygenase activity in spleen cells.
Leishmaniasis, Visceral
Parasitic load determination by differential expressions of 5-lipoxygenase and PGE2 synthases in visceral leishmaniasis.
Leukemia
1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.
12-Lipoxygenase from rat basophilic leukemia cells, an oxygenase with leukotriene A4-synthase activity.
12-Lipoxygenase from rat basophilic leukemia cells: separation from 5-lipoxygenase and temperature-dependent inactivation by hydroperoxy fatty acid.
5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO.
5-Lipoxygenase inhibitors potentiate effects of TGF-beta 1 on the differentiation of human leukemia HL-60 cells.
A Calluna vulgaris extract 5-lipoxygenase inhibitor shows potent antiproliferative effects on human leukemia HL-60 cells.
Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum.
Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.
Arachidonate 5-lipoxygenase inhibitors show potent antiproliferative effects on human leukemia cell lines.
Biochemical and biological activities of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol (L-651,896), a novel topical anti-inflammatory agent.
Characterization of specific subcellular 15-hydroxyeicosatetraenoic acid (15-HETE) binding sites on rat basophilic leukemia cells.
Co-localization of leukotriene a4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils.
Dexamethasone increases expression of 5-lipoxygenase and its activating protein in human monocytes and THP-1 cells.
Effect of azelastine on the release and action of leukotriene C4 and D4.
Effects of the new 5-lipoxygenase inhibitor E6080 on leukotriene release in vitro.
Effects of the rhizomes of Atractylodes japonica and atractylenolide I on allergic response and experimental atopic dermatitis.
Experiments on the mode of action of piriprost (U-60,257), an inhibitor of leukotriene formation in cloned mouse mast cells and in rat basophil leukemia cells.
In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production.
Inhibition of Experimental Atopic Dermatitis by Rhubarb (Rhizomes of Rheum tanguticum) and 5-Lipoxygenase Inhibition of its Major Constituent, Emodin.
Inhibition of leukotriene synthesis by azelastine.
Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine, and synergism between diethylcarbamazine and piriprost, a 5-lipoxygenase inhibitor.
Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells.
Interactions of 5-lipoxygenase with membranes: studies on the association of soluble enzyme with membranes and alterations in enzyme activity.
Isolation and characterization of a cDNA clone encoding rat 5-lipoxygenase.
Kinetic studies on arachidonate 5-lipoxygenase from rat basophilic leukemia cells.
Leukotriene C4 uses a probenecid-sensitive export carrier that does not recognize leukotriene B4.
Localization of 5-lipoxygenase to the nucleus of resting rat basophilic leukemia cells.
Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells.
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.
Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis.
Mono (S) hydroxy fatty acids: novel ligands for cytosolic actin.
Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors.
Novel bishydroxamic acids as 5-lipoxygenase inhibitors.
Novel Combination Treatments Targeting Chronic Myeloid Leukemia Stem Cells.
Novel membrane target proteins for lipoxygenase-derived mono(S)hydroxy fatty acids.
Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells.
Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase.
Pharmacological properties of a new anti-inflammatory compound, alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)-gamma-butyrolacto ne (KME-4), and its inhibitory effects on prostaglandin synthetase and 5-lipoxygenase.
Purification of a mammalian 5-lipoxygenase from rat basophilic leukemia cells.
Purification, characterization, and structural properties of a single protein from rat basophilic leukemia (RBL-1) cells possessing 5-lipoxygenase and leukotriene A4 synthetase activities.
Regulation of lipoxygenase activity by polyunsaturated lysophosphatidylcholines or their oxygenation derivatives.
Saiboku-To, a herbal extract mixture, selectively inhibits 5-lipoxygenase activity in leukotriene synthesis in rat basophilic leukemia-1 cells.
Serum vascular endothelial growth factor and COX-2/5-LOX inhibition in advanced non-small cell lung cancer: Cancer and Leukemia Group B 150304.
Stimulation of leukotriene production and membrane translocation of 5-lipoxygenase by cross-linking of the IgE receptors in RBL-2H3 cells.
Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells.
Studies on lipoxygenase inhibitors. I. MY3-469 (3-methoxytropolone), a potent and selective inhibitor of 12-lipoxygenase, produced by Streptoverticillium hadanonense KY11449.
Studies on lipoxygenase inhibitors. II. KF8940 (2-n-heptyl-4-hydroxyquinoline-N-oxide), a potent and selective inhibitor of 5-lipoxygenase, produced by Pseudomonas methanica.
Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.
Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues.
Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.
The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia.
The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor.
The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2.
The pharmacologic effects of 5-[3,5-bis(1,1-dimethylethyl)-4- hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione, choline salt (CI-986), a novel inhibitor of arachidonic acid metabolism in models of inflammation, analgesia and gastric irritation.
The regulation of 5-lipoxygenase activity in rat basophilic leukemia cells.
The Rhizomes of Acorus gramineus and the Constituents Inhibit Allergic Response In vitro and In vivo.
The Rhizomes of Alisma orientale and Alisol Derivatives Inhibit Allergic Response and Experimental Atopic Dermatitis.
Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages.
Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model.
[Studies on 5-lipoxygenase inhibitors. Synthesis of and structure--activity relationship in p-hydroxyarylalkenylbenzoazoles]
Leukemia, Erythroblastic, Acute
Altered gravity modulates 5-lipoxygenase in human erythroleukemia K562 cells.
Lipoxygenase activity in altered gravity.
Leukemia, Monocytic, Acute
Dexamethasone increases expression of 5-lipoxygenase and its activating protein in human monocytes and THP-1 cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A 5-lipoxygenase inhibitor at micromolar concentration raises intracellular calcium in U937 cells prior to their physiologic cell death.
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.
Morphologic changes of apoptosis induced in human chronic myelogenous leukemia "blast" cells by SC41661A (Searle), a selective inhibitor of 5-lipoxygenase.
Selective inhibitors of 5-lipoxygenase reduce CML blast cell proliferation and induce limited differentiation and apoptosis.
The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia.
[Knockdown of Alox5 gene promotes apoptosis of K562/ADM cells].
Leukemia, Myeloid
Regulation of leukotriene-biosynthetic enzymes during differentiation of myelocytic HL-60 cells to eosinophilic or neutrophilic cells.
[Relationship between Polymorphism in ALOX5, ALOX5AP and Susceptibility to Myeloid Leukemia].
Leukemia, Myeloid, Acute
5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia.
Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase.
Leukocytosis
Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation.
Leukopenia
Differential protective activities of site specific lipoxygenase inhibitors in endotoxic shock and production of tumor necrosis factor.
Haemodynamic and haematologic effects of Acanthaster planci venom in dogs.
Leukotriene B4 is involved in hemodialysis-associated neutropenia.
Leydig Cell Tumor
Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene.
Lipidoses
Lipidosis induced in the dog gallbladder by a direct 5-lipoxygenase inhibitor.
Liver Cirrhosis
5-Lipoxygenase (5-LO) is Involved in Kupffer Cell Survival. Possible Role of 5-LO Products in the Pathogenesis of Liver Fibrosis.
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.
Differential effects of malotilate on 5-, 12- and 15-lipoxygenase in human ascites cells.
Eicosanoid production by density-defined human peritoneal macrophages during inflammation.
Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis.
Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis.
Inhibition of 5-lipoxygenase induces cell growth arrest and apoptosis in rat Kupffer cells: implications for liver fibrosis.
Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells.
Liver Diseases
5-lipoxygenase activation is involved in the mechanisms of chronic hepatic injury in a rat model of chronic aluminum overload exposure.
Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor.
Inhibition of 5-lipoxygenase induces cell growth arrest and apoptosis in rat Kupffer cells: implications for liver fibrosis.
Inhibition of 5-lipoxygenase inhibitor zileuton in high-fat diet-induced nonalcoholic fatty liver disease progression model.
Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice.
[The roles of cyclooxygenase-2 and 5-lipoxygenase in liver disease]
Liver Failure, Acute
Inhibition of 5-lipoxygenase pathway attenuates acute liver failure by inhibiting macrophage activation.
Lung Diseases
Cyclooxygenase- and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid from patients with scleroderma lung disease: an imbalance between proinflammatory and antiinflammatory lipid mediators.
Fuscoside: an anti-inflammatory marine natural product which selectively inhibits 5-lipoxygenase. Part II: Biochemical studies in the human neutrophil.
Lung Diseases, Interstitial
The arachidonate 5-lipoxygenase activating protein gene polymorphism is associated with the risk of scleroderma-related interstitial lung disease: a multicentre European Scleroderma Trials and Research group (EUSTAR) study.
Lung Diseases, Obstructive
The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).
Lung Injury
5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan.
5-lipoxygenase pathway is essential for the control of granuloma extension induced by Schistosoma mansoni eggs in lung.
Acute pancreatitis.
Increase in filtration coefficient from actions of melittin on neutrophils in isolated rabbit lungs.
Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity.
Leukotriene inhibitors attenuate rat lung injury induced by hydrogen peroxide.
Oleic acid induces pulmonary injury independent of eicosanoids in the isolated, perfused rabbit lung.
Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury.
Pivotal Role of 5-Lipoxygenase Pathway in Lung Injury After Experimental Sepsis.
Reduction of neutrophil influx diminishes lung injury and mortality following phosgene inhalation.
Lung Neoplasms
A genomic response of H-358 bronchiolar carcinoma cells to MK 886, an inhibitor of 5-lipoxygenase, assessed with a cDNA array.
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203.
Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling.
miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.
The future of cyclooxygenase-2 inhibitors and other inhibitors of the eicosanoid signal pathway in the prevention and therapy of lung cancer.
The mode of cell death in H-358 lung cancer cells cultured with inhibitors of 5-lipoxygenase or the free radical spin trap, NTBN.
Lupus Erythematosus, Systemic
A pilot study of zileuton, a novel selective 5-lipoxygenase inhibitor, in patients with systemic lupus erythematosus.
Chemiluminescence is increased in a subgroup of PHA-stimulated lymphocytes from patients with systemic lupus erythematosus and inhibited by 5-lipoxygenase inhibitors.
Lyme Disease
Leukotriene B4 receptor BLT1 signaling is critical for neutrophil apoptosis and resolution of experimental Lyme arthritis.
Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of Lyme arthritis.
Macrophage LTB
Lymphatic Metastasis
5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage.
Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells.
Lymphedema
Leukotriene B4 antagonism ameliorates experimental lymphedema.
Lymphoma
5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation.
Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase-mediated mitochondrial uncoupling and cytochrome c release.
Intrinsic 5-lipoxygenase activity regulates migration and adherence of mantle cell lymphoma cells.
Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells.
Lymphoma, B-Cell
Intrinsic 5-lipoxygenase activity regulates migration and adherence of mantle cell lymphoma cells.
Lymphoma, Mantle-Cell
Intrinsic 5-lipoxygenase activity regulates migration and adherence of mantle cell lymphoma cells.
Lymphoma, T-Cell
5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation.
Malaria
Deoxyhypusine Hydroxylase from Plasmodium vivax, the Neglected Human Malaria Parasite: Molecular Cloning, Expression and Specific Inhibition by the 5-LOX Inhibitor Zileuton.
The oxylipin and endocannabidome responses in acute phase Plasmodium falciparum malaria in children.
Malaria, Cerebral
Differences in the modulation of reactive species, lipid bodies, cyclooxygenase-2, 5-lipoxygenase and PPAR-? in cerebral malaria-susceptible and resistant mice.
Mastocytoma
A new 5-lipoxygenase selective inhibitor derived from Artocarpus communis strongly inhibits arachidonic acid-induced ear edema.
Enhancement of 5-lipoxygenase activity in mastocytoma P-815 cells by n-butyrate treatment.
L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor.
Predominant synthesis of 5-hydroxyeicosatetraenoic acid by a cloned mastocytoma P-815 line, 2-E-6 cells.
Selective inhibition of 5-lipoxygenase by natural compounds isolated from Chinese plants, Artemisia rubripes Nakai.
Medulloblastoma
Leukotriene Synthesis Is Critical for Medulloblastoma Progression.
Melanoma
A Mixture of Polyunsaturated Fatty Acids ?-3 and ?-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment.
Cytoplasmic phospholipase A2 metabolites play a critical role in pulmonary tumor metastasis in mice.
Inhibitors of 5-lipoxygenase inhibit expression of intercellular adhesion molecule-1 in human melanoma cells.
Ketoconazole: a thromboxane synthetase and 5-lipoxygenase inhibitor with antimetastatic activity in B16-F10 melanoma.
Leukotriene B4 creates a favorable microenvironment for murine melanoma growth.
Meningioma
Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas?
Mesothelioma
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Metabolic Diseases
5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation.
Metabolic Syndrome
17? Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats.
Miosis
Effect of sodium naproxen on inflammatory response induced by anterior chamber paracentesis in the rabbit.
Mouth Neoplasms
Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol.
Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism.
Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.
Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors.
Multiple Sclerosis
A Systematic Review on the Role of Arachidonic Acid Pathway in Multiple Sclerosis.
Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders.
Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions.
Suppression of experimental autoimmune encephalomyelitis by sulfasalazine.
Muscular Atrophy
Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy.
Mycoses
5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.
Leukotriene B4-loaded microspheres as a new approach to enhance antimicrobial responses in Histoplasma capsulatum-infected mice.
Myeloproliferative Disorders
Deficient induction of leukotriene synthesis in human neutrophils by lipoxygenase-deficient platelets.
Myocardial Infarction
5-Lipoxygenase facilitates healing after myocardial infarction.
A functional Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene is not associated with myocardial infarction.
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction.
Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway.
Arachidonate 5-lipoxygenase (5-LO) promoter genotype and risk of myocardial infarction: a case-control study.
Association of ALOX5AP with ischemic stroke: a population-based case-control study.
Association of Sp1 tandem repeat polymorphism of ALOX5 with coronary artery disease in Indian subjects.
Biomarkers and Bioassays for Cardiovascular Diseases: Present and Future.
Cardioprotective effect of 5-lipoxygenase gene (ALOX5) silencing in ischemia-reperfusion.
Common Polymorphisms in the 5-Lipoxygenase Pathway and Risk of Incident Myocardial Infarction: A Danish Case-Cohort Study.
Design and rationale of FLAVOUR: A phase IIa efficacy study of the 5-lipoxygenase activating protein antagonist AZD5718 in patients with recent myocardial infarction.
Genetic polymorphisms that predict outcome and need for treatment in cardiovascular disease.
Increased urinary leukotriene excretion in patients with cardiac ischemia. In vivo evidence for 5-lipoxygenase activation.
Influence of atherosclerosis on the vascular reactivity of isolated human epicardial coronary arteries to leukotriene C4.
Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction.
Inhibitory effects of a phosphate diester of alpha-tocopherol and ascorbic acid (EPC-K1) on myocardial infarction in rats.
Interactions between 5-Lipoxygenase Polymorphisms and Adipose Tissue Contents of Arachidonic and Eicosapentaenoic Acids Do Not Affect Risk of Myocardial Infarction in Middle-Aged Men and Women in a Danish Case-Cohort Study.
Leukotriene B4 production in healthy subjects carrying variants of the arachidonate 5-lipoxygenase-activating protein gene associated with a risk of myocardial infarction.
Monoclonal anti-CD18 antibody prevents transcellular biosynthesis of cysteinyl leukotrienes in vitro and in vivo and protects against leukotriene-dependent increase in coronary vascular resistance and myocardial stiffness.
Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction.
Reduction of myocardial infarct size in rats by a selective 5-lipoxygenase inhibitor (AA-861).
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.
The potential link between atherosclerosis and the 5-lipoxygenase pathway: investigational agents with new implications for the cardiovascular field.
Validation of the association between the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a Japanese population.
Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
Water-soluble quercetin modulates the choleresis and bile lipid ratio in rats.
[Study on mechanisms and myocardial protective effect of Qishen Yiqi dropping pills on rats with myocardial infarction].
Myocardial Ischemia
Increased urinary leukotriene excretion in patients with cardiac ischemia. In vivo evidence for 5-lipoxygenase activation.
Modulation of coronary flow rate and cardiac contractility by the divalent cation ionophore A23187 and inhibitors of the cyclooxygenase and 5-lipoxygenase pathways: development of heterogeneous patterns of myocardial ischemia.
Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice.
The selective 5-LOX inhibitor 11-keto-?-boswellic acid protects against myocardial ischemia reperfusion injury in rats: involvement of redox and inflammatory cascades.
Myositis
The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis.
nad(p)h oxidase (h2o2-forming) deficiency
Novel effect of oxidized low-density lipoprotein: cellular ATP depletion via downregulation of glyceraldehyde-3-phosphate dehydrogenase.
nadph dehydrogenase (quinone) deficiency
NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis.
Nasal Obstruction
[Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]
Nasal Polyps
Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma.
Expression of Arachidonate Metabolism Enzymes and Receptors in Nasal Polyps of Aspirin-Hypersensitive Asthmatics.
Expression of COX-1, COX-2, 5-LOX and CysLT 2 in nasal polyps and bronchial tissue of patients with aspirin exacerbated airway disease.
Expression of cyclooxygenase-2 and 5-lipoxygenase in nasal polyps associated with interleukin-4 promoter polymorphism -590.
Neoplasm Metastasis
15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary.
5-Lipoxygenase Antagonist therapy: a new approach towards targeted cancer chemotherapy.
5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage.
5-Lipoxygenase promotes epithelial-mesenchymal transition through the ERK signaling pathway in gastric cancer.
5-Lipoxygenase: Its involvement in gastrointestinal malignancies.
Anti-Cancer Activity of 2,4-Disubstituted Thiophene Derivatives: Dual Inhibitors of Lipoxygenase and Cyclooxygenase.
Cytoplasmic phospholipase A2 metabolites play a critical role in pulmonary tumor metastasis in mice.
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
Effects of Celebrex and Zyflo on liver metastasis and lipidperoxidation in pancreatic cancer in Syrian hamsters.
Enhanced metastatic ability of TNF-alpha-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotides.
Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells.
Inhibitor of 5-lipoxygenase, zileuton, suppresses prostate cancer metastasis by upregulating E-cadherin and paxillin.
Inhibitors of 5-lipoxygenase inhibit expression of intercellular adhesion molecule-1 in human melanoma cells.
Multifaceted link between cancer and inflammation.
Neutrophils support lung colonization of metastasis-initiating breast cancer cells.
Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer.
The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis.
Neoplasms
1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity.
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth.
5,7-dihydroxy-2-(3-hydroxy-4, 5-dimethoxy-phenyl)-chromen-4-one-a flavone from Bruguiera gymnorrhiza displaying anti-inflammatory properties.
5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid.
5-Lipoxygenase and Cyclooxygenase inhibitory Dammarane triterpenoid 1 from Borassus flabellifer seed coat, inhibits Tumor Necrosis Factor-? secretion in LPS induced THP-1 human monocytes and induces apoptosis in MIA PaCa-2 Pancreatic cancer cells.
5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs.
5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue.
5-Lipoxygenase Antagonist therapy: a new approach towards targeted cancer chemotherapy.
5-lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear trafficking.
5-Lipoxygenase contributes to the progression of hepatocellular carcinoma.
5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice.
5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9.
5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity.
5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia.
5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage.
5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices.
5-Lipoxygenase promotes epithelial-mesenchymal transition through the ERK signaling pathway in gastric cancer.
5-Lipoxygenase: Its involvement in gastrointestinal malignancies.
A Cell-based Assay for Screening Lipoxygenase Inhibitors.
A Mixture of Polyunsaturated Fatty Acids ?-3 and ?-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment.
A novel anti-pancreatic cancer agent, LY293111.
A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-?B in HCT116 human colon cancer cells.
A Phase 1/2 Study of Flavocoxid, an Oral NF-?B Inhibitor, in Duchenne Muscular Dystrophy.
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.
Absence of modulation of monokine production via endogenous cyclooxygenase or 5-lipoxygenase metabolites: MK-886 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2- dimethylpropanoic acid), indomethacin, or arachidonate fail to alter immunoreactive interleukin-1 beta, or TNF-alpha production by human monocytes in vitro.
Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth.
Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor.
Alpha-tocopherol decreases tumor necrosis factor-alpha mRNA and protein from activated human monocytes by inhibition of 5-lipoxygenase.
Altered eicosanoid levels in human colon cancer.
Altered oncogene, tumor suppressor and cell-cycle gene expression in PANC-1 cells cultured with the pleiotrophic 5-lipoxygenase inhibitor, MK886, assessed with a gene chip.
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.
Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics.
Anti-Cancer Activity of 2,4-Disubstituted Thiophene Derivatives: Dual Inhibitors of Lipoxygenase and Cyclooxygenase.
Anti-inflammatory activity of four Bolivian Baccharis species (Compositae).
Anti-inflammatory and analgesic potential of Tamarindus indica Linn. (Fabaceae): a narrative review.
Anti-inflammatory effect of methoxyflavonoids from Chiliadenus montanus (Jasonia Montana) growing in Egypt.
Anti-proliferative effects of lichen-derived lipoxygenase inhibitors on twelve human cancer cell lines of different tissue origin in vitro.
Anticancer effects of licofelone (ML-3000) in prostate cancer cells.
Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages.
Arachidonate 5 lipoxygenase expression in papillary thyroid carcinoma promotes invasion via MMP-9 induction.
Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas?
Assessment of the expression of biomarkers of uremic inflammation in dogs with renal disease.
Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating NF-kappa B activation in response to tumor necrosis factor-alpha and interleukin-1beta.
Berberine Inhibits the Apoptosis-Induced Metastasis by Suppressing the iPLA2/LOX-5/LTB4 Pathway in Hepatocellular Carcinoma.
Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas.
Black Tea: Phytochemicals, Cancer Chemoprevention and Clinical Studies.
CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma via 5-lipoxygenase.
Cancer chemoprevention by 7-prenyloxycoumarins: a role for 5-lipoxygenase inhibition?
Cancer-Produced Metabolites of 5-Lipoxygenase Induce Tumor-Evoked Regulatory B Cells via Peroxisome Proliferator-Activated Receptor ?.
CarbORev-5901: The First Carborane-Based Inhibitor of the 5-Lipoxygenase Pathway.
Cassia sieberiana DC. leaves modulate LPS-induced inflammatory response in THP-1 cells and inhibit eicosanoid-metabolizing enzymes.
Chemical Composition of Pterospermum heterophyllum Root and its Anti-Arthritis Effect on Adjuvant-Induced Arthritis in Rats via Modulation of Inflammatory Responses.
Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol.
Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention.
Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice.
Chronic adventitial inflammation, vasa vasorum expansion, and 5-lipoxygenase up-regulation in irradiated arteries from cancer survivors.
Composition and Mechanism of Antitumor Effects of Hericium erinaceus Mushroom Extracts in Tumor-Bearing Mice.
Computer modeling in predicting the bioactivity of human 5-lipoxygenase inhibitors.
Conjugated linoleic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice through dual inhibition of COX-2/5-LOX and TLR4/NF-?B signaling.
Conjugated linoleic acid reduction of murine mammary tumor cell growth through 5-hydroxyeicosatetraenoic acid.
Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway.
Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.
CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide.
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.
Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy.
Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells.
Cytoplasmic 5-Lipoxygenase Staining Is a Highly Sensitive Marker of Human Tumors of the Choroid Plexus.
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
Dendropanax dentiger (Harms) Merr. root and its major constituents exert therapeutic effect on adjuvant-induced arthritis in rats.
Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase.
Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents.
Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation.
Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.
Discovery of small molecule acting as multitarget inhibitor of colorectal cancer by simultaneous blocking of the key COX-2, 5-LOX and PIM-1 kinase enzymes.
Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription.
Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.
Dual acting anti-inflammatory drugs.
Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke.
Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro.
DuCLOX-2/5 Inhibition Attenuates Inflammatory Response and Induces Mitochondrial Apoptosis for Mammary Gland Chemoprevention.
DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention.
Effects of D,L-2-difluoromethylornithine and indomethacin on mammary tumor promotion in rats fed high n-3 and/or n-6 fat diets.
Effects of phenidone (DuCLOX-2/5 inhibitor) against N-methyl-N-nitrosourea induced mammary gland carcinoma in albino rats.
Effects of tenuiorin and methyl orsellinate from the lichen Peltigera leucophlebia on 5-/15-lipoxygenases and proliferation of malignant cell lines in vitro.
Eicosapentaenoic acid reduces the invasive and metastatic activities of malignant tumor cells.
Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer's Disease-Like Features in Rats.
Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells.
Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors.
Ethanolic extract of Pyrus pashia buch ham ex. D. Don (Kainth): A bioaccessible source of polyphenols with anti-inflammatory activity in vitro and in vivo.
Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa.
Evaluation of in vitro biological activities: antioxidant; anti-inflammatory; anti-cholinesterase; anti- xanthine oxidase, anti-superoxyde dismutase, anti-?-glucosidase and cytotoxic of 19 bioflavonoids.
Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumors.
Evidence of human cytomegalovirus infection and expression of 5-lipoxygenase in borderline ovarian tumors.
Evidence that interleukin-1 beta and tumor necrosis factor inhibit gastric fundus motility via the 5-lipoxygenase pathway.
Expression of 5-lipoxygenase in human colorectal cancer.
Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemoprevention.
Five-lipoxygenase-activating protein inhibitor MK-886 induces apoptosis in gastric cancer through upregulation of p27kip1 and bax.
Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: A comparison study with methylprednisolone.
Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis.
Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis.
Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13.
Gene expression of immunologically important factors in blood cells, milk cells, and mammary tissue of cows.
Genotoxic activity and induction of biotransformation enzymes in two human cell lines after treatment by Erika fuel extract.
Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity.
Human 5-, 12- and 15-lipoxygenase-1 coexist in kidney but show opposite trends and their balance changes in cancer.
Increased expression of the 5-lipoxygenase pathway and its cellular localization in Barrett's adenocarcinoma.
Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration.
Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats.
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer.
Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene.
Inflammatory Process and Molecular Targets for Antiinflammatory Nutraceuticals.
Influx of extracellular calcium is required for the membrane translocation of 5-lipoxygenase and leukotriene synthesis.
Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells.
Inhibition of 5-lipoxygenase downregulates stemness and kills prostate cancer stem cells by triggering apoptosis via activation of c-Jun N-terminal kinase.
Inhibition of 5-lipoxygenase pathway suppresses the growth of bladder cancer cells.
Inhibition of 5-lipoxygenase suppresses vascular endothelial growth factor-induced angiogenesis in endothelial cells.
Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells.
Inhibition of human 5-lipoxygenase and anti-neoplastic effects by 2-amino-1,4-benzoquinones.
Inhibition of mediator and cytokine release from dispersed nasal polyp cells by mizolastine.
Inhibition of tumour growth by lipoxygenase inhibitors.
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.
Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis.
Inhibitory Effects of Panduratin A on Allergy-Related Mediator Production in Rat Basophilic Leukemia Mast Cells.
Interactions between cytokines and eicosanoids: a study using human peritoneal macrophages.
Intracellular Ca2+ mediates lipoxygenase-induced proliferation of U-373 MG human astrocytoma cells.
Involvement of 5-lipoxygenase in programmed cell death of cancer cells.
Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase.
Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors.
Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation.
Isoflavone-rich extracts from wooly glycine Glycine tomentella inhibits LPS-induced TNF-alpha expression in a macrophage cell line of Atlantic salmon (Salmo salar L.).
Kukoamine A inhibits human glioblastoma cell growth and migration through apoptosis induction and epithelial-mesenchymal transition attenuation.
Leukotriene B4 creates a favorable microenvironment for murine melanoma growth.
Leukotriene B4.
Leukotriene C4 is an essential 5-lipoxygenase intermediate in A23187-induced macrophage cytostatic activity against P815 tumor cells.
Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis.
Leukotriene Synthesis Is Critical for Medulloblastoma Progression.
Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention.
Lipoxygenase directed anti-inflammatory and anti-cancerous secondary metabolites: ADMET-based screening, molecular docking and dynamics simulation.
Lipoxygenase inhibitors but not site specific 5-lipoxygenase blockers protect against endotoxic shock and inhibit production of tumor necrosis factor.
Loss of natural killer T cells promotes pancreatic cancer in LSL-Kras(G12D/+) mice.
LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space.
Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction.
Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells.
Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.
Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504).
Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.
Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells.
Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis.
Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer.
MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis.
MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation.
MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: synergistic action with LY294002, an inhibitor of phosphatidylinositol 3'-kinase.
Molecular chaperones stimulate bone resorption.
Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery.
Multifaceted link between cancer and inflammation.
N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity.
Neurogenesis and neuroprotection in the adult brain. A putative role for 5-lipoxygenase?
Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation.
New pyridone, thioxopyridine, pyrazolopyridine and pyridine derivatives that modulate inflammatory mediators in stimulated RAW 264.7 murine macrophage.
Nicotine inhibits cytokine synthesis by mouse colonic mucosa.
Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway.
Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats.
Novel anti-tumour activity of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4- benzoquinone (CV-6504) against established murine adenocarcinomas (MAC).
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
Omega-3 fatty acid regulates inflammatory cytokine/mediator messenger RNA expression in Porphyromonas gingivalis-induced experimental periodontal disease.
On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Overexpression of 5-lipoxygenase and its relation with cell proliferation and angiogenesis in 7,12-dimethylbenz(?)anthracene-induced rat mammary carcinogenesis.
Overexpression of 5-Lipoxygenase in Colon Polyps and Cancer and the Effect of 5-LOX Inhibitors In vitro and in a Murine Model.
Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis.
Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.
Pharmacokinetic analysis by high-performance liquid chromatography of intravenous nordihydroguaiaretic acid in the mouse.
Pharmacological intervention of cyclooxygenase-2 and 5-lipoxygenase pathways. Impact on inflammation and cancer.
Photodynamic Therapeutic Role of Indocyanine Green in Tumor-Associated Inflammation in Skin Cancer.
Photothermal therapeutic effect of PEGylated gold nano-semicubes in chemically-induced skin cancer in mice.
Polymorphisms in candidate asthma genes.
Polyunsaturated Fatty Acid Diet and Upregulation of Lipoxin A4 Reduce the Inflammatory Response of Preeclampsia.
Predominant synthesis of 5-hydroxyeicosatetraenoic acid by a cloned mastocytoma P-815 line, 2-E-6 cells.
Prevalence of 5-Lipoxygenase Expression in Canine Osteosarcoma and the Effects of a Dual 5-Lipoxygenase/Cyclooxygenase Inhibitor on Osteosarcoma Cells In Vitro and In Vivo.
Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids.
Priming for the synthesis of 5-lipoxygenase products in human blood ex vivo by human granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha.
Proliferation of estrogen-responsive mouse tumor cell line B-1F stimulated by Saiboku-to, but inhibited by Scutellaria baicalensis, a component of Saiboku-to.
Protective effect of (+)-catechin against lipopolysaccharide-induced inflammatory response in RAW 264.7 cells through downregulation of NF-?B and p38 MAPK.
Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas.
Reduced release of leukotrienes B4 and C4 from alveolar macrophages of rats with silicosis.
Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells.
Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?
Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors.
Research Article Flavocoxid Protects Against Cadmium-Induced Disruption of the Blood-Testis Barrier and Improves Testicular Damage and Germ Cell Impairment in Mice.
Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice.
Role of eicosanoids in prostate cancer progression.
Salix tetrasperma Roxb. Extract Alleviates Neuropathic Pain in Rats via Modulation of the NF-?B/TNF-?/NOX/iNOS Pathway.
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
Serum 5-LOX: a progressive protein marker for breast cancer and new approach for therapeutic target.
Serum vascular endothelial growth factor and COX-2/5-LOX inhibition in advanced non-small cell lung cancer: Cancer and Leukemia Group B 150304.
Short-term intensive atorvastatin therapy improves endothelial function partly via attenuating perivascular adipose tissue inflammation through 5-lipoxygenase pathway in hyperlipidemic rabbits.
Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma.
Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice.
Sterols and triterpenoids as potential anti-inflammatories: Molecular docking studies for binding to some enzymes involved in inflammatory pathways.
Study of the polymorphisms of cyclooxygenase-2 (-765G>C) and 5-lipoxygenase (1708G>A) in patients with colorectal cancer.
Study on antitumor activities of the chrysin-chromene-spirooxindole on Lewis lung carcinoma C57BL/6 mice in vivo.
Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines.
Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase.
Synthesis and evaluation of 5-lipoxygenase translocation inhibitors from acylnitroso hetero-Diels-Alder cycloadducts.
Synthesis of new anticancer and anti-inflammatory isoxazolines and aziridines from the natural (-)-deltoin.
Synthesis of New Harmine Isoxazoles and Evaluation of their Potential Anti-Alzheimer, Anti-inflammatory, and Anticancer Activities.
Synthesis of new isoxazoline derivatives from harmine and evaluation of their anti-Alzheimer, anti-cancer and anti-inflammatory activities.
Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.
Tagitinin F has anti-inflammatory, anti-nociceptive and anti-matrix metalloproteinase properties: An in silico, in vitro and in vivo study.
Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer.
Targeting Lipid Peroxidation for Cancer Treatment.
Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression.
Tepoxalin a dual 5-LOX-COX inhibitor and erlotinib an EGFR inhibitor halts progression of gastric cancer in tumor xenograft mice.
TGF?/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation.
The 5-lipoxygenase inhibitor tepoxalin induces oxidative damage and altered PTEN status prior to apoptosis in canine osteosarcoma cell lines.
The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia.
The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice.
The arachidonic acid-LTB4-BLT2 pathway enhances human B-CLL aggressiveness.
The effect of 5-lipoxygenase inhibition on blood-brain barrier permeability in experimental brain tumors.
The emerging role of targeting cancer metabolism for cancer therapy.
The expression of cytosolic phospholipase A2 and biosynthesis of leukotriene B4 in acute myeloid leukemia cells.
The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.
The future of cyclooxygenase-2 inhibitors and other inhibitors of the eicosanoid signal pathway in the prevention and therapy of lung cancer.
The inhibitory activity of cocoa phenolic extract against pro-inflammatory mediators secretion induced by lipopolysaccharide in RAW 264.7 cells.
The involvement of protein kinase C, calcium, and 5-lipoxygenase in the production of tumor necrosis factor by a cloned interleukin-3 dependent cell line with natural cytotoxic activity.
The mRNA overexpression of inflammatory enzymes, phospholipase A2 and cyclooxygenase, in the large bowel mucosa and neoplasms of F344 rats treated with naturally occurring carcinogen, 1-hydroxyanthraquinone.
The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).
The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications.
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model.
Vitamin E metabolite 13'-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice.
Zinc and iron complexes of oleanolic acid, (OA) attenuate allergic airway inflammation in rats.
[Study on mechanisms and myocardial protective effect of Qishen Yiqi dropping pills on rats with myocardial infarction].
Nephritis
Increased 5-lipoxygenase activating protein in immune-mediated experimental nephritis.
Nephrotic Syndrome
5-Lipoxygenase and leukotriene A4 hydrolase expression in primary nephrotic syndrome.
Gene expression of 5-lipoxygenase and LTA4 hydrolase in renal tissue of nephrotic syndrome patients.
Nephrotic syndrome associated with N-hydroxyureas, inhibitors of 5-lipoxygenase.
Neuroblastoma
5-LOX in Alzheimer's Disease: Potential Serum Marker and In Vitro Evidences for Rescue of Neurotoxicity by Its Inhibitor YWCS.
Involvement of 5-lipoxygenase in programmed cell death of cancer cells.
Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.
Neurodegenerative Diseases
Evidence for using a dual COX 1/2 and 5-LOX inhibitor in neurodegenerative diseases.
Exploring N1-p-Fluorobenzyl-Cymserine as an Inhibitor of 5-Lipoxygenase as a Candidate for Type 2 Diabetes and Neurodegenerative Disorder Treatment.
Inflammatory 5-LOX mRNA and protein are increased in brain of aging rats.
Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation.
Neuroprotection of (+)-2-(1-Hydroxyl-4-Oxocyclohexyl) Ethyl Caffeate Against Hydrogen Peroxide and Lipopolysaccharide Induced Injury via Modulating Arachidonic Acid Network and p38-MAPK Signaling.
New anti-inflammatory treatment strategy in Alzheimer's disease.
Phosphorylation of 5-LOX: The Potential Set-point of Inflammation.
Protection of dopaminergic neurons by 5-lipoxygenase inhibitor.
The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis.
Neuroinflammatory Diseases
Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage.
Modulation of lipopolysaccharide-induced memory insult, ?-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase.
Naja sputatrix Venom Preconditioning Attenuates Neuroinflammation in a Rat Model of Surgical Brain Injury via PLA2/5-LOX/LTB4 Cascade Activation.
Neuroprotection of (+)-2-(1-Hydroxyl-4-Oxocyclohexyl) Ethyl Caffeate Against Hydrogen Peroxide and Lipopolysaccharide Induced Injury via Modulating Arachidonic Acid Network and p38-MAPK Signaling.
The natural dual cyclooxygenase and 5-lipoxygenase inhibitor flavocoxid is protective in EAE through effects on Th1/Th17 differentiation and macrophage/microglia activation.
Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.
Western blot expression of 5-lipoxygenase in the brain from striped dolphins (stenella coeruleoalba) and bottlenose dolphins (tursiops truncatus) with or without encephalitis/meningo-encephalitis of infectious nature.
Zileuton ameliorates depressive-like behaviors, hippocampal neuroinflammation, apoptosis and synapse dysfunction in mice exposed to chronic mild stress.
Neutropenia
The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma.
Non-alcoholic Fatty Liver Disease
Inhibition of 5-lipoxygenase inhibitor zileuton in high-fat diet-induced nonalcoholic fatty liver disease progression model.
Obesity
5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity.
A high-fat diet induces bone loss in mice lacking the Alox5 gene.
Arachidonate 5-lipoxygenase variants in atherosclerosis, obesity, and bone traits.
Cysteinyl Leukotrienes (CysLTs): Role in Obesity-Induced Asthma.
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits.
Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice.
Response to arachidonate 5-lipoxygenase variants in atherosclerosis, obesity, and bone traits.
The 5-lipoxygenase/leukotriene pathway in obesity, insulin resistance, and fatty liver disease.
Osteoarthritis
5-Lipoxygenase Metabolic Contributions to NSAID-Induced Organ Toxicity.
A new 5-lipoxygenase inhibitor seems to be safe and effective for the treatment of osteoarthritis.
A Randomized, Double Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Safety and Efficacy of Curene® versus Placebo in Reducing Symptoms of Knee OA.
Anticonvulsive Effects of Licofelone on Status Epilepticus Induced by Lithium-pilocarpine in Wistar Rats: a Role for Inducible Nitric Oxide Synthase.
Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the hip and knee: a multicenter 2-month clinical trial.
Efficacy and safety of flavocoxid compared with naproxen in subjects with osteoarthritis of the knee- a subset analysis.
Efficacy of licofelone in dogs with clinical osteoarthritis.
Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis.
In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase.
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis.
Licofelone (Merckle).
Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors.
Licofelone inhibits interleukin-18-induced pro-inflammatory cytokine release and cellular proliferation in human mesangial cells.
Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity.
Licofelone, a potent COX/5-LOX inhibitor and a novel option for treatment of neurological disorders.
Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis.
Licofelone: the answer to unmet needs in osteoarthritis therapy?
Lipoxygenase products and expression of 5-lipoxygenase and 5-lipoxygenase-activating protein in human cultured synovial cells.
Role of eicosanoids in structural degradation in osteoarthritis.
Safety of anti-inflammatory treatment--new ways of thinking.
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway.
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis.
Osteoarthritis, Knee
Protective effects of licofelone, a 5-lipoxygenase and cyclooxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first Multi-Centre Clinical Trial using quantitative MRI.
Osteosarcoma
A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells.
Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells.
Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis.
Prevalence of 5-Lipoxygenase Expression in Canine Osteosarcoma and the Effects of a Dual 5-Lipoxygenase/Cyclooxygenase Inhibitor on Osteosarcoma Cells In Vitro and In Vivo.
The 5-lipoxygenase inhibitor tepoxalin induces oxidative damage and altered PTEN status prior to apoptosis in canine osteosarcoma cell lines.
Ovarian Neoplasms
Acquired cisplatin resistance in human ovarian A2780 cancer cells correlates with shift in taurine homeostasis and ability to volume regulate.
Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration.
Lipoxygenase pathway receptor expression in ovarian cancer.
TRPM7 promotes the epithelial-mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling.
Overweight
The effect of low-dose marine n-3 fatty acids on the biosynthesis of pro-inflammatory 5-lipoxygenase pathway metabolites in overweight subjects: A randomized controlled trial.
Pancreatic Neoplasms
5-Lipoxygenase and Cyclooxygenase inhibitory Dammarane triterpenoid 1 from Borassus flabellifer seed coat, inhibits Tumor Necrosis Factor-? secretion in LPS induced THP-1 human monocytes and induces apoptosis in MIA PaCa-2 Pancreatic cancer cells.
5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue.
5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions.
A novel anti-pancreatic cancer agent, LY293111.
A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints.
Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor.
Altered oncogene, tumor suppressor and cell-cycle gene expression in PANC-1 cells cultured with the pleiotrophic 5-lipoxygenase inhibitor, MK886, assessed with a gene chip.
Caspase-dependent and -independent panc-1 cell death due to actinomycin D and MK 886 are additive but increase clonogenic survival.
Cyclooxygenases and lipoxygenases as potential targets for treatment of pancreatic cancer.
Effects of selective COX-2 and 5-LOX inhibition on prostaglandin and leukotriene synthesis in ductal pancreatic cancer in Syrian hamster.
Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors.
Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase.
Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid.
Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells.
Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase.
Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells.
Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells.
Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.
Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer.
Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model.
Pancreatitis
5-lipoxygenase knockout mice exhibit a resistance to acute pancreatitis induced by cerulein.
Acute pancreatitis.
Effects of dual inhibitor of cyclooxygenase and 5-lipoxygenase on acute necrotizing pancreatitis in rats.
Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis.
Inhibition of 5-lipoxygenase represses neutrophils activation and activates apoptosis in pancreatic tissues during acute necrotizing pancreatitis.
Leukotriene generation and neutrophil infiltration after experimental acute pancreatitis.
Protective effect of AA-861 (5-lipoxygenase inhibitor) on experimental acute necrotizing pancreatitis in rats.
Pancreatitis, Acute Necrotizing
Effects of dual inhibitor of cyclooxygenase and 5-lipoxygenase on acute necrotizing pancreatitis in rats.
Inhibition of 5-lipoxygenase represses neutrophils activation and activates apoptosis in pancreatic tissues during acute necrotizing pancreatitis.
Protective effect of AA-861 (5-lipoxygenase inhibitor) on experimental acute necrotizing pancreatitis in rats.
Paracoccidioidomycosis
5-Lipoxygenase Activity Increases Susceptibility to Experimental Paracoccidioides brasiliensis Infection.
Parasitemia
5-Lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi infection.
Parkinson Disease
Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders.
Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays.
Nutraceutical Potential of Phenolics from 'Brava' and 'Mansa' Extra-Virgin Olive Oils on the Inhibition of Enzymes Associated to Neurodegenerative Disorders in Comparison with Those of 'Picual' and 'Cornicabra'.
Protection of dopaminergic neurons by 5-lipoxygenase inhibitor.
[5-lipoxygenase is involved in rotenone-induced injury in PC12 cells].
Pemphigoid, Bullous
Increased levels of immunoreactive leukotriene B4 in blister fluids of bullous pemphigoid patients and effects of a selective 5-lipoxygenase inhibitor on experimental skin lesions.
Periapical Periodontitis
5-Lipoxygenase Knockout Aggravated Apical Periodontitis in a Murine Model.
Dual Role of 5-Lipoxygenase in Osteoclastogenesis in Bacterial-induced Apical Periodontitis.
Effects of 5-lipoxygenase gene disruption on inflammation, osteoclastogenesis and bone resorption in polymicrobial apical periodontitis.
Periodontal Diseases
Inhibition of 5-Lipoxygenase (5-Lo) Attenuates Inflammation and Bone Resorption in Lipopolysaccharide (Lps)-Induced Periodontal Disease.
Inhibition of 5-lipoxygenase attenuates inflammation and BONE resorption in lipopolysaccharide-induced periodontal disease.
Peripheral Nervous System Diseases
Toxic peripheral neuropathy with demyelination in Sprague-Dawley rats given CGS 21595--a 5-lipoxygenase inhibitor.
Peritonitis
Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.
Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice.
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.
Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase.
Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation.
[Effects of anti-toxic agents in septic shock]
Pharyngitis
Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats via inhibition of NF-?B and COX-2.
Pleural Effusion
LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space.
Possible involvement of eicosanoids in alpha-naphthylthiourea-induced pulmonary oedema and alteration of angiotensin-converting enzyme activity.
Pleurisy
5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan.
Anti-inflammatory profile of N-phenylpyrazole arylhydrazone derivatives in rats.
Arachidonic acid-induced pleurisy (ARIP): an in vivo model for testing 5-lipoxygenase inhibition.
Comparison of several new 5-lipoxygenase inhibitors in a rat Arthus pleurisy model.
Effects of TZI-41127, a novel selective 5-lipoxygenase inhibitor, on A23187-induced pleurisy in rats.
Inhibition of LTB4 biosynthesis in situ by CGS 23885, a potent 5-lipoxygenase inhibitor, correlates with its pleural fluid concentrations in an experimentally induced rat pleurisy model.
Involvement of leukotriene B4 in zymosan-induced rat pleurisy: inhibition of leukocyte infiltration by the 5-lipoxygenase inhibitor T-0757.
Role of leukotrienes in rat reversed passive Arthus pleurisy and the effect of AA-861, a 5-lipoxygenase inhibitor.
Roles of leukotrienes in two rat allergic inflammatory models; IgE-mediated and IgG-antigen complex-induced pleurisies.
Pleuropneumonia
5-Lipoxygenase and cyclooxygenase-2 in the lungs of pigs naturally affected by enzootic pneumonia and porcine pleuropneumonia.
Pneumonia
5-Lipoxygenase and cyclooxygenase-2 in the lungs of pigs naturally affected by enzootic pneumonia and porcine pleuropneumonia.
A controlled trial of the effect of the 5-lipoxygenase inhibitor, zileuton, on lung inflammation produced by segmental antigen challenge in human beings.
Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice.
Electrophilic Fatty Acid Species Inhibit 5-Lipoxygenase and Attenuate Sepsis-Induced Pulmonary Inflammation.
Inhibition by methylprednisolone of zymosan-induced leukotriene synthesis in alveolar macrophages.
Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor.
Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
Leukotrienes in pulmonary arterial hypertension.
Phenotypically-Silent Bone Morphogenetic Protein Receptor 2 (Bmpr2) Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing The Risk for Neointimal Transformation.
Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.
Role of 5-lipoxygenase in IL-13-induced pulmonary inflammation and remodeling.
The importance of leukotrienes in airway inflammation in a mouse model of asthma.
The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study.
Polycythemia Vera
A drug targeting 5-lipoxygenase enhances the activity of a JAK2 inhibitor in CD34+ bone marrow cells from patients with JAK2V617F-positive polycythemia vera in vitro.
Polymyositis
The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis.
Pouchitis
Increased leukotriene B4 release from ileal pouch mucosa in ulcerative colitis compared with familial adenomatous polyposis.
Pre-Eclampsia
Cyclooxygenase gene expression in human endometrium and decidua.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Diverse expression of cytosolic phospholipase A2, 5-lipoxygenase and prostaglandin H synthase 2 in acute pre-B-lymphocytic leukaemia cells.
Premature Birth
Plasma oxylipins and unesterified precursor fatty acids are altered by DHA supplementation in pregnancy: Can they help predict risk of preterm birth?
Prostatic Hyperplasia
Effects of flavocoxid, a dual inhibitor of COX and 5-lipoxygenase enzymes, on benign prostatic hyperplasia.
Prostatic Neoplasms
15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells.
5-Lipoxygenase expression in benign and malignant canine prostate tissues.
Activation of the orphan nuclear receptor RORalpha counteracts the proliferative effect of fatty acids on prostate cancer cells: crucial role of 5-lipoxygenase.
Anticancer effects of licofelone (ML-3000) in prostate cancer cells.
Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase.
Central role of arachidonate 5-lipoxygenase in the regulation of cell growth and apoptosis in human prostate cancer cells.
Chemistry and biology for the small molecules targeting characteristics of cancer cells.
Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription.
Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid, and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid.
Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival.
Fatty acid oxidation and signaling in apoptosis.
Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk.
Inhibition of 5-lipoxygenase downregulates stemness and kills prostate cancer stem cells by triggering apoptosis via activation of c-Jun N-terminal kinase.
Inhibition of 5-Lipoxygenase Selectively Triggers Disruption of c-Myc Signaling in Prostate Cancer Cells.
Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon.
Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells.
Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase.
Inhibitor of 5-lipoxygenase, zileuton, suppresses prostate cancer metastasis by upregulating E-cadherin and paxillin.
Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction.
MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: synergistic action with LY294002, an inhibitor of phosphatidylinositol 3'-kinase.
MK591, a second generation leukotriene biosynthesis inhibitor, prevents invasion and induces apoptosis in the bone-invading C4-2B human prostate cancer cells: implications for the treatment of castration-resistant, bone-metastatic prostate cancer.
Molecular mechanisms of prostate cancer cell death triggered by inhibition of arachidonate 5-lipoxygenase: involvement of Fas death receptor-mediated signals.
OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells.
Pharmacological and genetic targeting of 5-lipoxygenase interrupts c-Myc oncogenic signaling and kills enzalutamide-resistant prostate cancer cells via apoptosis.
Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase.
Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines.
The effects of oral Cardax (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo.
Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKC? without inhibiting Akt.
Proteinuria
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.
Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat.
Functional significance of leukotriene B4 in normal and glomerulonephritic kidneys.
Inhibition of 5-lipoxygenase activating protein decreases proteinuria in diabetic rats.
Involvement of lipid mediators in the pathogenesis of experimental nephrosis in rats: its pharmacological modulation.
Involvement of thromboxane A2, leukotrienes and free radicals in puromycin nephrosis in rats.
Pruritus
Double-blinded, placebo-controlled, cross-over pilot study on the efficacy of zileuton for canine atopic dermatitis.
Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.
Potential new therapeutic targets for pathological pruritus.
Psoriasis
5-Lipoxygenase activation in psoriasis: a dead issue?
A double-blind vehicle-controlled study of R 68 151 in psoriasis: a topical 5-lipoxygenase inhibitor.
Arachidonic acid metabolism by polymorphonuclear leukocytes in psoriasis.
Chemotactic lipoxygenase products in sera from patients with psoriasis.
Current status and recent developments in anthracenone antipsoriatics.
Effect of 5-lipoxygenase inhibition on events associated with inflammatory bowel disease in rats.
Fuscoside: an anti-inflammatory marine natural product which selectively inhibits 5-lipoxygenase. Part II: Biochemical studies in the human neutrophil.
In vitro inhibition of leukotriene B4 formation by exogeneous 5-lipoxygenase inhibitors is associated with enhanced generation of 15-hydroxy-eicosatetraenoic acid (15-HETE) by human neutrophils.
Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions.
Inhibition of ionophore-stimulated leukotriene B4 production in human leucocytes by monohydroxy fatty acids.
Modulation of epidermal cell division and growth by oxygenation products of arachidonic acid.
n-3 fatty acids in psoriasis.
Non steroidal anti-inflammatory and anti-allergy agents.
Percutaneous absorption and metabolism of lonapalene in psoriatic skin.
Pharmacologic and clinical effects of lonapalene (RS 43179), a 5-lipoxygenase inhibitor, in psoriasis.
Polymorphonuclear leukocyte 5-lipoxygenase activity in psoriasis.
Potent antagonism of calmodulin activity in vitro, but lack of antiproliferative effects on keratinocytes by the novel leukotriene biosynthesis inhibitor MK-886.
Selective decrease of 15-hydroxyeicosatetraenoic acid (15-HETE) formation in uninvolved psoriatic dermis.
Significance of leukotriene-A4 hydrolase in the pathogenesis of psoriasis.
Sulfasalazine in treatment of psoriasis.
The inflammatory response of rabbit skin to topical arachidonic acid and its pharmacological modulation.
Topical nonsteroidal antipsoriatic agents. 2. 2,3-(Alkylidenedioxy)naphthalene analogues of lonapalene.
Topical R-85355, a potent and selective 5-lipoxygenase inhibitor, fails to improve psoriasis.
[Leukotrienes. A review of the significance for disease in man and the possibilities for therapeutic intervention]
[Partially hydrogenated aryl-1,2/1,4-anthraquinone derivatives, 5-lipoxygenase inhibitors with arotinoid structure]
Pulmonary Arterial Hypertension
A new treatment for severe pulmonary arterial hypertension based on an old idea: inhibition of 5-lipoxygenase.
HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension.
Pulmonary Atelectasis
Antagonism of leukotriene receptors and administration of a 5-lipoxygenase inhibitor do not affect hypoxic vasoconstriction.
Pulmonary Disease, Chronic Obstructive
5-lipoxygenase inhibitors for the treatment of COPD.
A turn on and a turn off: BLT1 and BLT2 mechanisms in the lung.
Effect of the 5-lipoxygenase inhibitor, fenleuton, on antigen-induced neutrophil accumulation and lung function changes in horses with chronic obstructive pulmonary disease.
Leukotrienes in respiratory disease.
Lipid peroxidation and 5-lipoxygenase activity in chronic obstructive pulmonary disease.
MK-0633, a potent 5-lipoxygenase inhibitor, in chronic obstructive pulmonary disease.
Phytochemical study, molecular docking, genotoxicity and therapeutic efficacy of the aqueous extract of the stem bark of Ximenia americana L. in the treatment of experimental COPD in rats.
The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).
Pulmonary Eosinophilia
A semisynthetic diterpenoid lactone inhibits NF-?B signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model.
Eotaxin and RANTES enhance 5-oxo-6,8,11,14-eicosatetraenoic acid-induced eosinophil chemotaxis.
Suppressive effects of F-1322 on the antigen-induced late asthmatic response and pulmonary eosinophilia in guinea pigs.
Pulmonary Fibrosis
Cysteinyl-leukotriene 1 receptor antagonist attenuates bleomycin-induced pulmonary fibrosis in mice.
Protection from pulmonary fibrosis in leukotriene-deficient mice.
The 5-lipoxygenase pathway: a new therapeutic target for the treatment of pulmonary fibrosis.
Renal Insufficiency
Protective effect of peptide leukotriene antagonist on renal failure induced by a tourniquet in rabbits.
Renal Insufficiency, Chronic
Inhibition of 5-Lipoxygenase Decreases Renal Fibrosis and Progression of Chronic Kidney Disease.
Reperfusion Injury
Characterization of LY233569 on 5-lipoxygenase and reperfusion injury of ischemic myocardium.
Effect of nordihydroguaiaretic acid on behavioral impairment and neuronal cell death after forebrain ischemia.
Effects of the arachidonate 5-lipoxygenase synthesis inhibitor A-64077 in intestinal ischemia-reperfusion injury.
In vivo correlation of neutrophil receptor expression, ischemia-reperfusion injury, and selective 5-lipoxygenase inhibition in guinea pigs.
Ischemia-reperfusion injury in myocutaneous flaps: role of leukocytes and leukotrienes.
Protective effect of the 5-lipoxygenase inhibitor ardisiaquinone A on hepatic ischemia-reperfusion injury in rats.
Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.
Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice.
Systemic neutrophil intrinsic 5-lipoxygenase activity and CD18 receptor expression linked to reperfusion injury.
The role of 5-lipoxygenase and leukotrienes in shock and ischemia-reperfusion injury.
The selective 5-LOX inhibitor 11-keto-?-boswellic acid protects against myocardial ischemia reperfusion injury in rats: involvement of redox and inflammatory cascades.
[Mechanism of Musk and Borneol on Inflammatory of Cerebral Ischemia and Reperfusion Injury at Different Time Points of Acute Phase in Rats].
Respiratory Distress Syndrome
Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis.
Therapeutic intervention in a rat model of adult respiratory distress syndrome: II. Lipoxygenase pathway inhibition.
Therapeutic intervention in a rat model of ARDS: I. Dual inhibition of arachidonic acid metabolism.
Respiratory Hypersensitivity
Leukotriene enhanced allergic lung inflammation through induction of chemokine production.
Respiratory Insufficiency
5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury.
Rhinitis, Allergic
Allergen-stimulated leukotriene B4 and interleukin-8 levels in patients with asthma and allergic rhinitis-modulation by a lipid pathway inhibitor.
Potential anti-inflammatory effects of 5-lipoxygenase inhibition--exemplified by the leukotriene synthesis inhibitor BAY X 1005.
Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor.
The effects of anti-PAF and other agents on the nasal symptoms in sensitized guinea pigs.
The influence of 5-lipoxygenase inhibition in allergic rhinitis.
The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).
[Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]
Rhinitis, Allergic, Seasonal
Leukotrienes as mediators of nasal inflammation.
Randomized double-blind, placebo-controlled clinical trial of a selective 5-lipoxygenase inhibitor (AA-861) for the prevention of seasonal allergic rhinitis.
Schistosomiasis
Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni.
Scleroderma, Systemic
Evidence of 5-lipoxygenase overexpression in the skin of patients with systemic sclerosis: a newly identified pathway to skin inflammation in systemic sclerosis.
Seizures
Are leukotrienes or PAF involved in hyperbaric oxygen toxicity?
On the relation between cerebral cysteinyl-leukotriene formation and epileptic seizures.
Sepsis
5-Lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates Lipid A endotoxin-induced inflammation.
Colonic microvascular integrity in acute endotoxaemia: interactions between constitutive nitric oxide and 5-lipoxygenase products.
Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis.
In silico system pharmacology for the potential bioactive ingredients contained in Xingnaojing Injection () and Its material basis for sepsis treatment.
Induction of inducible nitric oxide synthase by lipopolysaccharide/interferon gamma and sepsis down-regulates 5-lipoxygenase metabolism in murine alveolar macrophages.
Inhibition of 5-lipoxygenase is associated with downregulation of the leukotriene B4 receptor 1/ Interleukin-12p35 pathway and ameliorates sepsis-induced myocardial injury.
Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes.
Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis.
Pivotal Role of 5-Lipoxygenase Pathway in Lung Injury After Experimental Sepsis.
Sinusitis
Advances in upper airway diseases and allergen immunotherapy.
Frankincense--therapeutic properties.
Sjogren-Larsson Syndrome
5-Lipoxygenase inhibition: a new treatment strategy for Sjögren-Larsson syndrome.
Skin Diseases
Cellular and biochemical characterization of the anti-inflammatory effects of DuP 654 in the arachidonic acid murine skin inflammation model.
Identification of 4-[4-(4-fluoro-phenyl)-thiazol-2-ylamino]-2,6-dimethyl-phenol (KR-33749) as an inhibitor of 5-lipoxygenase with potent antiinflammatory activity.
In vitro 5-Lipoxygenase and Anti-Oxidant Activities of South African Medicinal Plants Commonly Used Topically for Skin Diseases.
Inhibition of ionophore-stimulated leukotriene B4 production in human leucocytes by monohydroxy fatty acids.
The lipoxygenase inhibitor 2-phenylmethyl-1-naphthol (DuP 654) is a 12(S)-hydroxyeicosatetraenoic acid receptor antagonist in the human epidermal cell line SCL-II.
Treatment of hyperkeratotic skin diseases with R 68151, a topical 5-lipoxygenase inhibitor: four case reports.
Skin Neoplasms
Topical chemoprevention of skin cancer in mice, using combined inhibitors of 5-lipoxygenase and cyclo-oxygenase-2.
Sleep Apnea, Obstructive
Urine Concentrations of Cysteinyl Leukotrienes in Children With Obstructive Sleep-Disordered Breathing.
Spasm
Influence of atherosclerosis on the vascular reactivity of isolated human epicardial coronary arteries to leukotriene C4.
Spinal Cord Injuries
Involvement of 5-lipoxygenase in spinal cord injury.
Thromboxane and 5-HETE increase after experimental spinal cord injury in rabbits.
Squamous Cell Carcinoma of Head and Neck
5-lipoxygenase expression and tepoxalin-induced cell death in squamous cell carcinomas in cats.
5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells.
ST Elevation Myocardial Infarction
Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction.
Staphylococcal Infections
Reconstitution of Staphylococcus aureus Lipoteichoic Acid Synthase Activity Identifies Congo Red as a Selective Inhibitor.
Stomach Neoplasms
15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
5-Lipoxygenase promotes epithelial-mesenchymal transition through the ERK signaling pathway in gastric cancer.
Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth.
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer.
The role of transient receptor potential channel blockers in human gastric cancer cell viability.
Upregulation of leukotriene receptors in gastric cancer.
Stomach Ulcer
5-Lipoxygenase products: their biosynthesis in human gastric mucosa and possible involvement in inflammatory response and oxygen saturation index reduction in gastric ulcer patients.
Antiulcer Potential of Olea europea L. cv. Arbequina Leaf Extract Supported by Metabolic Profiling and Molecular Docking.
Stroke
5-Lipoxygenase activating protein (ALOX5AP): association with cardiovascular infarction and stroke.
Advances in the genetic basis of coronary artery disease.
ALOX5AP gene and the PDE4D gene in a central European population of stroke patients.
Association of 5-lipoxygenase activating protein gene polymorphism and stroke: A study from north east of Iran.
Association of ALOX5AP with ischemic stroke in eastern Chinese.
Association of ALOX5AP1 SG13S114T/A variant with ischemic stroke, stroke subtypes and aspirin resistance.
Genetic polymorphisms that predict outcome and need for treatment in cardiovascular disease.
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.
Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia.
Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese.
Interaction of genetic risk factors confers higher risk for thrombotic stroke in male Chinese: a multicenter case-control study.
Phosphodiesterase 4D and 5-lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians.
Polymorphism of SG13S114T/A in the ALOX5AP gene and the risk for stroke in a large Chinese cohort.
Synergistic effect of ALOX5AP polymorphisms and cigarette smoking on the risk of atherosclerotic cerebral infarction in a Northern Han Chinese population.
Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke.
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.
The potential link between atherosclerosis and the 5-lipoxygenase pathway: investigational agents with new implications for the cardiovascular field.
Validation of the association between the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a Japanese population.
[Polymorphic variants of ALOX5AP gene and the risk of acute stroke development in the Russian population].
Subarachnoid Hemorrhage
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Effect of leukotrienes, 12-HETE, histamine, bradykinin, and 5-hydroxytryptamine on in vivo rabbit cerebral arteriolar diameter.
The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage.
Tauopathies
Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice.
Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase.
Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy.
Pharmacologic Inhibition of 5-Lipoxygenase Improves Memory, Rescues Synaptic Dysfunction, and Ameliorates Tau Pathology in a Transgenic Model of Tauopathy.
The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy.
Testicular Neoplasms
Relationship between lipoxygenase and human testicular cancer.
Thrombocytopenia
Haemodynamic and haematologic effects of Acanthaster planci venom in dogs.
Thrombosis
Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus.
Impact of Aspirin Eugenol Ester on Cyclooxygenase-1, Cyclooxygenase-2, C-Reactive Protein, Prothrombin and Arachidonate 5-Lipoxygenase in Healthy Rats.
Prevention of thrombosis and vascular inflammation: benefits and limitations of selective or combined COX-1, COX-2 and 5-LOX inhibitors.
[Prevention of thrombosis and vascular inflammation: importance of combined cyclooxygenase and 5-lipoxygenase inhibitors]
Thyroid Cancer, Papillary
Arachidonate 5 lipoxygenase expression in papillary thyroid carcinoma promotes invasion via MMP-9 induction.
Toxic Optic Neuropathy
Optimization of imidazole 5-lipoxygenase inhibitors and selection and synthesis of a development candidate.
Toxoplasmosis
Lipoxin A? and 15-epi-lipoxin A? protect against experimental cerebral malaria by inhibiting IL-12/IFN-? in the brain.
Trypanosomiasis
Biological activities of xanthatin from Xanthium strumarium leaves.
Tuberculosis
ALOX5 variants associated with susceptibility to human pulmonary tuberculosis.
Chemokine secretion by human polymorphonuclear granulocytes after stimulation with Mycobacterium tuberculosis and lipoarabinomannan.
Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis.
Tularemia
Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia.
Ureteral Obstruction
Increases in glomerular eicosanoid production in rats with bilateral ureteral obstruction are mediated by enhanced enzyme activities of both the cyclooxygenase and 5-lipoxygenase pathways.
Urinary Bladder Neoplasms
Antitumor effects of lipoxygenase inhibitors on murine bladder cancer cell line (MBT-2).
Inhibition of 5-lipoxygenase pathway suppresses the growth of bladder cancer cells.
Inhibition of human 5-lipoxygenase and anti-neoplastic effects by 2-amino-1,4-benzoquinones.
Lipoxygenase Protein Expression and Its Effect on Oxidative Stress Caused by Benzidine in Normal Human Urothelial Cell Lines.
Urologic Neoplasms
Lipoxygenase inhibitors prevent urological cancer cell growth.
Urticaria
NSAID-induced urticaria and angioedema: a reappraisal of its clinical management.
Uterine Cervical Neoplasms
Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells.
Uveitis
Concomitant treatment with a 5-lipoxygenase inhibitor improves the anti-inflammatory effect of the inhibition of nitric oxide synthase during the early phase of endotoxin-induced uveitis in the rabbit.
Steroidal and nonsteroidal drugs in endotoxin-induced uveitis.
The role of arachidonate metabolites in ocular inflammation.
Vascular Diseases
5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9.
Vascular Ring
Variable effects of human and canine polymorphonuclear leucocytes on vascular smooth muscle tone.
Vascular System Injuries
Leukocyte mediated vein injury and thrombosis is reduced by a lipoxygenase inhibitor.
Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury.
Vasospasm, Intracranial
Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery.
Effect of 5-lipoxygenase inhibitor on experimental delayed cerebral vasospasm.
Participation of vasopressin in the development of cerebral vasospasm in a rat model of subarachnoid haemorrhage.
The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage.
Ventilator-Induced Lung Injury
5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury.
Virus Diseases
The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications.
Whooping Cough
15-Hydroxyeicosatetraenoic acid (15-HETE) receptors. Involvement in the 15-HETE-induced stimulation of the cryptic 5-lipoxygenase in PT-18 mast/basophil cells.
Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins.
Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel.
Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway.
Regulation of the human leukocyte 5-lipoxygenase: stimulation by micromolar Ca2+ levels and phosphatidylcholine vesicles.
Xanthomatosis
5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia.