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Information on EC 1.14.13.189 - 5-methyl-1-naphthoate 3-hydroxylase for references in articles please use BRENDA:EC1.14.13.189Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The expected taxonomic range for this enzyme is: Streptomyces sahachiroi
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5-methyl-1-naphthoate 3-hydroxylase
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5-methyl-1-naphthoate + NADPH + H+ + O2 = 3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O
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5-methyl-1-naphthoate,NADPH:oxygen oxidoreductase (3-hydroxylating)
The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B.
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brenda
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physiological function
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the enzyme is involved in biosynthesis of 3-methoxy-5-methyl-1-naphthoate a component of of the the antitumor antibiotic azinomycin B
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5-methyl-1-naphthoate + NADPH + H+ + O2
3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O
5-methyl-1-naphthoate + NADPH + H+ + O2
3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O
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5-methyl-1-naphthoate + NADPH + H+ + O2
3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O
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the enzyme is involved in biosynthesis of 3-methoxy-5-methyl-1-naphthoate a component of of the the antitumor antibiotic azinomycin B
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5-methyl-1-naphthoate + NADPH + H+ + O2
3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O
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the enzyme is involved in biosynthesis of 3-methoxy-5-methyl-1-naphthoate a component of of the the antitumor antibiotic azinomycin B
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additional information
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a heme-thiolate protein (P450)
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0.013
NADPH
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pH 9.0, 25°C
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0.0054
NADPH
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pH 9.0, 25°C
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7 - 10
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pH 7.0: about 45% of maximal activity, pH 10.0: about 80% of maximal activity
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expression in Streptomyces albus or in Escherichia coliBö21(DE3)
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AZIB1_STREG
401
45109
Swiss-Prot
A0A231HE01_9NOCA
414
45655
TrEMBL
A0A1S1NKU5_9MYCO
394
42873
TrEMBL
A0A1S1NR07_9MYCO
382
42165
TrEMBL
A0A2R8AQ98_9RHOB
397
44250
TrEMBL
A0A1S1NR39_9MYCO
397
44264
TrEMBL
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Ding, W.; Deng, W.; Tang, M.; Zhang, Q.; Tang, G.; Bi, Y.; Liu, W.
Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B
Mol. Biosyst.
6
1071-1081
2010
Streptomyces sahachiroi
brenda
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