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Information on EC 1.2.1.91 - 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase

for references in articles please use BRENDA:EC1.2.1.91

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IUBMB Comments

The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyses EC 3.3.2.12, oxepin-CoA hydrolase. Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway.

The enzyme appears in viruses and cellular organisms

Synonyms
EC 1.17.1.7, oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (NADP+), paaZ, PaaZ-ALDH, PacL, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + NADP+ + H2O = 3-oxo-5,6-dehydrosuberyl-CoA + NADPH + H+
show the reaction diagram
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