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Information on EC 1.2.1.97 - 3-sulfolactaldehyde dehydrogenase

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EC Tree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.97 3-sulfolactaldehyde dehydrogenase

IUBMB Comments

The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway. Also acts on succinate semialdehyde.

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The enzyme appears in viruses and cellular organisms

Reaction Schemes

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(2S)-3-sulfolactaldehyde

Synonyms

sla dehydrogenase, show all synonyms

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SLA dehydrogenase

3 entries

SLA dehydrogenase

Pseudomonas putida

735194

SLA dehydrogenase

Pseudomonas putida SQ1

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

(2S)-3-sulfolactaldehyde + NAD(P)+ + H2O = (2S)-3-sulfolactate + NAD(P)H + H+

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PATHWAY SOURCE

PATHWAYS

MetaCyc

sulfoquinovose degradation II

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SYSTEMATIC NAME

IUBMB Comments

(2S)-3-sulfolactaldehyde:NAD(P)+ oxidoreductase

The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway. Also acts on succinate semialdehyde.

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(2S)-3-sulfolactaldehyde + NAD+ + H2O

(2S)-3-sulfolactate + NADH + H+

2 entries

(2S)-3-sulfolactaldehyde + NADP+ + H2O

(2S)-3-sulfolactate + NADPH + H+

2 entries

(2S)-3-sulfolactaldehyde + NAD+ + H2O

(2S)-3-sulfolactate + NADH + H+

Pseudomonas putida

735194

(2S)-3-sulfolactaldehyde + NAD+ + H2O

(2S)-3-sulfolactate + NADH + H+

Pseudomonas putida SQ1

735194

(2S)-3-sulfolactaldehyde + NADP+ + H2O

(2S)-3-sulfolactate + NADPH + H+

Pseudomonas putida

735194

(2S)-3-sulfolactaldehyde + NADP+ + H2O

(2S)-3-sulfolactate + NADPH + H+

Pseudomonas putida SQ1

735194

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(2S)-3-sulfolactaldehyde + NAD+ + H2O

(2S)-3-sulfolactate + NADH + H+

2 entries

(2S)-3-sulfolactaldehyde + NADP+ + H2O

(2S)-3-sulfolactate + NADPH + H+

2 entries

(2S)-3-sulfolactaldehyde + NAD+ + H2O

(2S)-3-sulfolactate + NADH + H+

Pseudomonas putida

735194

(2S)-3-sulfolactaldehyde + NAD+ + H2O

(2S)-3-sulfolactate + NADH + H+

Pseudomonas putida SQ1

735194

(2S)-3-sulfolactaldehyde + NADP+ + H2O

(2S)-3-sulfolactate + NADPH + H+

Pseudomonas putida

735194

(2S)-3-sulfolactaldehyde + NADP+ + H2O

(2S)-3-sulfolactate + NADPH + H+

Pseudomonas putida SQ1

735194

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NAD+

NADP+

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.14

(2S)-3-sulfolactaldehyde

2 entries

0.14

(2S)-3-sulfolactaldehyde

Pseudomonas putida

with NAD+ as cosubstrate, in 50 mM Tris-HCl (pH 7.5), temperature not specified in the publication

735194

0.14

(2S)-3-sulfolactaldehyde

Pseudomonas putida

with NADP+ as cosubstrate, in 50 mM Tris-HCl (pH 7.5), temperature not specified in the publication

735194

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

11.4 - 11.8

(2S)-3-sulfolactaldehyde

2 entries

11.4

(2S)-3-sulfolactaldehyde

Pseudomonas putida

with NADP+ as cosubstrate, in 50 mM Tris-HCl (pH 7.5), temperature not specified in the publication

735194

11.8

(2S)-3-sulfolactaldehyde

Pseudomonas putida

with NAD+ as cosubstrate, in 50 mM Tris-HCl (pH 7.5), temperature not specified in the publication

735194

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

81.4 - 84.2

(2S)-3-sulfolactaldehyde

2 entries

81.4

(2S)-3-sulfolactaldehyde

Pseudomonas putida

with NADP+ as cosubstrate, in 50 mM Tris-HCl (pH 7.5), temperature not specified in the publication

735194

84.2

(2S)-3-sulfolactaldehyde

Pseudomonas putida

with NAD+ as cosubstrate, in 50 mM Tris-HCl (pH 7.5), temperature not specified in the publication

735194

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Pseudomonas putida

735194

brenda

Pseudomonas putida SQ1

735194

brenda

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

P0DOV9 pBLAST

SLAD_PSEPU

Pseudomonas putida

486

52149

Swiss-Prot

Show Sequence

A0A5J4E414 pBLAST

A0A5J4E414_9BACT

bacterium MnTg03

232

25022

TrEMBL

Show Sequence

A0A564FZQ7 pBLAST

A0A564FZQ7_9RHIZ

Methylobacterium dankookense

490

51615

TrEMBL

Show Sequence

A0A654A5T2 pBLAST

A0A654A5T2_9RHOB

Oceanicaulis sp. 350

491

52216

TrEMBL

Show Sequence

A0A554WZX8 pBLAST

A0A554WZX8_9BURK

Tepidimonas thermarum

492

52661

TrEMBL

Show Sequence

A0A2K4X601 pBLAST

A0A2K4X601_PSEVC

Pseudoalteromonas carrageenovora IAM 12662

475

51696

TrEMBL

Show Sequence

A0A554X8I5 pBLAST

A0A554X8I5_9BURK

Tepidimonas taiwanensis

492

52647

TrEMBL

Show Sequence

A0A509EFZ9 pBLAST

A0A509EFZ9_9RHIZ

Methylobacterium sp. SB0023/3

490

51517

TrEMBL

Show Sequence

A0A554WF85 pBLAST

A0A554WF85_9BURK

Tepidimonas aquatica

492

52585

TrEMBL

Show Sequence

A0A2H5ZSW8 pBLAST

A0A2H5ZSW8_9BACT

bacterium HR31

482

52496

TrEMBL

Show Sequence

A0A5S9RCQ4 pBLAST

A0A5S9RCQ4_MYCVN

Mycolicibacterium vanbaalenii

514

54374

TrEMBL

Show Sequence

A0A645HT98 pBLAST

A0A645HT98_9ZZZZ

bioreactor metagenome

10130

TrEMBL

Show Sequence

other Location (Reliability: 2)

A0A554WM32 pBLAST

A0A554WM32_9BURK

Tepidimonas sediminis

492

52866

TrEMBL

Show Sequence

A0A645J345 pBLAST

A0A645J345_9ZZZZ

bioreactor metagenome

132

14309

TrEMBL

Show Sequence

other Location (Reliability: 3)

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

735194

Felux A.-K, F.A.; Spiteller D, S.D.; Klebensberger J, K.J.; Schleheck D, S.D.

Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1

Proc. Natl. Acad. Sci. USA

112

E4298-E4305

2015

Pseudomonas putida, Pseudomonas putida SQ1

26195800

brenda

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EXTERNAL LINKS (specific for EC-Number 1.2.1.97)

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

IUBMB Enzyme Nomenclature

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)

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