Disease on EC 1.6.5.4 - monodehydroascorbate reductase (NADH)

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DISEASE
TITLE OF PUBLICATION
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Adenocarcinoma
Association studies of the copy-number variable ß-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis.
Identification of defensin alpha6 as a potential biomarker in colon adenocarcinoma.
Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/beta-catenin/Tcf pathway.
PPARgamma as a sensor of lipase activity and a target for the lipase inhibitor orlistat.
Salivary Proteome and Peptidome Profiling in Type 1 Diabetes Mellitus Using a Quantitative Approach.
Adenoma
Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients.
Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/beta-catenin/Tcf pathway.
Adenomatous Polyposis Coli
Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli.
Adenoviridae Infections
Mechanism of adenovirus neutralization by Human alpha-defensins.
Aggressive Periodontitis
Beta-sheet antibiotic peptides as potential dental therapeutics.
Human beta defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases.
Airway Obstruction
Increased Expression of Beta-Defensin 1 (DEFB1) in Chronic Obstructive Pulmonary Disease.
Alzheimer Disease
Relevance of defensin ?-2 and ? defensins (HNP1-3) in Alzheimer's disease.
Anemia
Neutrophil gelatinase-associated lipocalin and hepcidin: what do they have in common and is there a potential interaction?
Anthrax
Through the looking glass, mechanistic insights from enantiomeric human defensins.
Appendicitis
Acute appendicitis: transcript profiling of blood identifies promising biomarkers and potential underlying processes.
Aspergillosis
Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms.
Asthma
Association of defensin beta-1 gene polymorphisms with asthma.
Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells.
The signature of long-standing balancing selection at the human defensin beta-1 promoter.
Atherosclerosis
Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells.
Autoimmune Diseases
An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses.
Bacterial Infections
Defensin from disk abalone Haliotis discus discus: molecular cloning, sequence characterization and immune response against bacterial infection.
Inducible immune factors of the vector mosquito Anopheles gambiae: biochemical purification of a defensin antibacterial peptide and molecular cloning of preprodefensin cDNA.
Keratinocyte expression of human beta defensin 2 following bacterial infection: role in cutaneous host defense.
Knock-down of REL2, but not defensin A, augments Aedes aegypti susceptibility to Bacillus subtilis and Escherichia coli.
Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots.
Neopterin, Interleukin-6, Procalcitonin, C-Reactive Protein And PET-CT Staining As Markers In Infected Total Knee Prosthesis, A Retrospective Analysis.
Overexpression of Porcine Beta-Defensin 2 Enhances Resistance to Actinobacillus pleuropneumoniae Infection in Pigs.
Parasitic infection protects wasp larvae against a bacterial challenge.
Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptides.
Regulation of antimicrobial peptide expression in human gingival keratinocytes by interleukin-1?
The sandfly Lutzomyia longipalpis LL5 embryonic cell line has active Toll and Imd pathways and shows immune responses to bacteria, yeast and Leishmania.
Blister
Human beta defensin is absent in burn blister fluid.
Breast Neoplasms
Challenging metastatic breast cancer with the natural defensin PvD
The defensin from avocado (Persea americana var. drymifolia) PaDef induces apoptosis in the human breast cancer cell line MCF-7.
Bronchitis, Chronic
Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects.
Candidiasis
In vitro activity of the antifungal plant defensin RsAFP2 against Candida isolates and its in vivo efficacy in prophylactic murine models of candidiasis.
Candidiasis, Oral
Dynamic changes of Th1/Th2/Th17 cytokines and human beta defensin 2 in HIV-infected patients with oral candidiasis during the first year of highly active anti-retroviral therapy.
Carcinogenesis
Defensins induce the recruitment of dendritic cells in cervical human papillomavirus-associated (pre)neoplastic lesions formed in vitro and transplanted in vivo.
Prevalent Homozygous Deletions of Type I Interferon and Defensin Genes in Human Cancers Associate with Immunotherapy Resistance.
The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila.
Carcinoma
Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients.
Effect of defensin peptides on eukaryotic cells: primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines.
Expression profile of drosomycin-like defensin in oral epithelium and oral carcinoma cell lines.
Human neutrophil defensin and serpins form complexes and inactivate each other.
Presence of defensin in epithelial Langerhans cells adjacent to oral carcinomas and precancerous lesions.
Carcinoma, Squamous Cell
Effect of defensin peptides on eukaryotic cells: primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines.
Cardiovascular Diseases
Cardiovascular disease and serum defensin levels in systemic lupus erythematosus.
Cataract
Ascorbate free radical reductase and ascorbate redox cycle in the human lens.
Chagas Disease
Cellular Response to Trypanosoma cruzi infection induces Secretion of Defensin ?-1, Which Damages the Flagellum, Neutralizes Trypanosome Motility and Inhibits Infection.
Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction.
Isolation and characterization of a novel insect defensin from Rhodnius prolixus, a vector of Chagas disease.
Chediak-Higashi Syndrome
Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.
Cholesteatoma
Association between human beta defensin expression and cholesteatoma formation.
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma.
Cholesteatoma, Middle Ear
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma.
Chorioamnionitis
Amniotic fluid defensins: potential markers of subclinical intrauterine infection.
Neutrophil granule products: can they identify subclinical chorioamnionitis in patients with preterm premature rupture of membranes?
Chronic Periodontitis
Human beta defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases.
[The impact of smoking on human beta defensin 2,3 in gingival crevicular fluid and gingival tissue of patients with chronic periodontitis].
Coinfection
[Changes of functional activity of peripheral blood leukocytes during the immunotherapy of tick-borne infections in children].
Colitis
Chronic colitis induces expression of ?-defensins in murine intestinal epithelial cells.
Guardians of the Gut: Enteric Defensins.
Human Defensin-5 Blocks Ethanol and Colitis-Induced Dysbiosis, Tight Junction Disruption and Inflammation in Mouse Intestine.
[The role of defensins in the pathogenesis of chronic-inflammatory bowel disease]
Colitis, Ulcerative
Construction of recombinant E. coli Nissle 1917 (EcN) strains for the expression and secretion of defensins.
Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli.
Defensins and Paneth cells in inflammatory bowel disease.
Improvement of a 'Leaky' Intestinal Barrier.
[Chronic inflammatory bowel diseases (IBD): novel pathophysiological concepts and their clinical relevance]
[The role of defensins in the pathogenesis of chronic-inflammatory bowel disease]
Colonic Diseases
A new look at Crohn's disease: breakdown of the mucosal antibacterial defense.
Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease.
Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.
Colonic Neoplasms
Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate.
Identification of defensin alpha6 as a potential biomarker in colon adenocarcinoma.
Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/beta-catenin/Tcf pathway.
Colorectal Neoplasms
Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients.
Defensin alpha 6 (DEFA6) is a prognostic marker in colorectal cancer.
Communicable Diseases
Antimycobacterial agent based on mRNA encoding human beta-defensin 2 enables primary macrophages to restrict growth of Mycobacterium tuberculosis.
Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.
Diesel exhaust particles increase IL-1beta-induced human beta-defensin expression via NF-kappaB-mediated pathway in human lung epithelial cells.
Human defensins: turning defense into offense?
Is the Enzyme-linked Immunosorbent Assay More Accurate Than the Lateral Flow Alpha Defensin Test for Diagnosing Periprosthetic Joint Infection?
Role of defensins in inflammatory lung disease.
Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.
[Transfection of human beta defensin 2 gene into the lung by aerosol inhalation: experiment with rats]
Crohn Disease
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.
Abnormal Pap smears in women with Crohn's disease: is there a role for defensin deficiency?
An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses.
Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease.
Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease.
Construction of recombinant E. coli Nissle 1917 (EcN) strains for the expression and secretion of defensins.
Crohn's disease: a defensin deficiency syndrome?
Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype.
Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.
Defensin-barbed innate immunity: clinical associations in the pediatric population.
Defensins and Paneth cells in inflammatory bowel disease.
Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease.
Hepcidin and inflammatory bowel disease: dual role in host defence and iron homoeostasis.
Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease.
Impaired luminal processing of human defensin-5 in Crohn's disease: persistence in a complex with chymotrypsinogen and trypsin.
Improvement of a 'Leaky' Intestinal Barrier.
Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn's disease.
Innate immune defenses in the intestinal tract.
NOD2 and defensins: translating innate to adaptive immunity in Crohn's disease.
NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation.
Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa.
Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease.
Two Cheers for Crohn's Disease and Periodontitis: Beta-Defensin-2 as an Actionable Target to Intervene on Two Clinically Distinct Diseases.
[Chronic inflammatory bowel diseases (IBD): novel pathophysiological concepts and their clinical relevance]
[The role of defensins in the pathogenesis of chronic-inflammatory bowel disease]
Cystic Fibrosis
Diesel exhaust particles increase IL-1beta-induced human beta-defensin expression via NF-kappaB-mediated pathway in human lung epithelial cells.
Expression of human beta defensin (HBD-1 and HBD-2) mRNA in nasal epithelia of adult cystic fibrosis patients, healthy individuals, and individuals with acute cold.
Role of defensins in inflammatory lung disease.
Dehydration
Antioxidant response of wheat roots to drought acclimation.
Antioxidative protection in the inducible CAM plant Sedum album L. following the imposition of severe water stress and recovery.
Effect of short-term water deficit stress on antioxidative systems in cucumber seedling roots.
Effect of water stress on antioxidant systems and oxidative parameters in fruits of tomato (Solanum lycopersicon L, cv. Micro-tom).
Redox Regulation of Monodehydroascorbate Reductase by Thioredoxin y in Plastids Revealed in the Context of Water Stress.
Response of the physiological parameters of mango fruit (transpiration, water relations and antioxidant system) to its light and temperature environment.
Dental Caries
Salivary protein polymorphisms and risk of dental caries: a systematic review.
Dermatitis, Atopic
Esophageal human ?-defensin expression in eosinophilic esophagitis.
IL-33 Modulates the Expression of Human Beta Defensin 2 in Human Primary Keratinocytes and may influence the susceptibility to bacterial superinfection in acute atopic dermatitis.
Intestinal defensin secretion in infancy is associated with the emergence of sensitization and atopic dermatitis.
Diabetic Neuropathies
Impact of Low-Frequency Pulsed Magnetic Fields on Defensin and CRP Concentrations in Patients with Painful Diabetic Polyneuropathy and in Healthy Subjects.
Dry Eye Syndromes
Effect of hyperosmolality on beta-defensin gene expression by human corneal epithelial cells.
Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye.
Eczema
IL-33 Modulates the Expression of Human Beta Defensin 2 in Human Primary Keratinocytes and may influence the susceptibility to bacterial superinfection in acute atopic dermatitis.
Endometritis
Association between elevated neutrophil defensin levels and endometritis.
Endophthalmitis
beta-Defensin 1 haplotype associated with postoperative endophthalmitis.
Enterocolitis, Necrotizing
Enteric defensin expression in necrotizing enterocolitis.
Enterovirus Infections
Induction and antiviral activity of human ?-defensin 3 in intestinal cells with picornavirus infection.
Focal Infection
Expression and Localization of Human Defensins in Palatine Tonsils.
Gastritis
Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status.
Defensin-mRNA Expression in the Upper Gastrointestinal Tract Is Modulated in Children With Celiac Disease and Helicobacter pylori-positive Gastritis.
Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis.
Potential role of human beta-defensin 1 in Helicobacter pylori-induced gastritis.
Gastroesophageal Reflux
Esophageal human ?-defensin expression in eosinophilic esophagitis.
Gingivitis
Human beta defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases.
Hepatitis
Administration of Poly[di(sodium carboxylatoethylphenoxy)phosphazene] (PCEP) and Avian Beta Defensin as Adjuvants in Inactivated Inclusion Body Hepatitis Virus and its Hexon Protein-Based Experimental Vaccine Formulations in Chickens.
Hepatitis B
A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro.
Herpes Zoster
Differentially-Expressed Genes Associated with Faster Growth of the Pacific Abalone, Haliotis discus hannai.
HIV Infections
An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses.
Are defensin beta 1 gene polymorphisms associated with HIV infection and virus replication?
Chronic HIV infection is associated with upregulation of pro-inflammatory cytokine and chemokine and alpha defensin gene expression in colorectal mucosa.
Copy number variation of defensin genes and HIV infection in Brazilian children.
Hyperglycemia
Glucose and insulin are needed for optimal defensin expression in human cell lines.
Hypersensitivity
Soluble CD14, ?-and ?-defensins in breast milk: Association with the emergence of allergy in a high-risk population.
Idiopathic Pulmonary Fibrosis
Diesel exhaust particles increase IL-1beta-induced human beta-defensin expression via NF-kappaB-mediated pathway in human lung epithelial cells.
Role of defensins in inflammatory lung disease.
Ileitis
From intestinal stem cells to inflammatory bowel diseases.
Infections
?-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome.
A comparative study of intraoperative frozen section and alpha defensin lateral flow test in the diagnosis of periprosthetic joint infection.
A Kampo (traditional Japanese herbal) medicine, Hochuekkito, pretreatment in mice prevented influenza virus replication accompanied with GM-CSF expression and increase in several defensin mRNA levels.
A Murine Model of Inflammatory Bladder Disease: Cathelicidin Peptide Induced Bladder Inflammation and Treatment With Sulfated Polysaccharides.
A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Clostridioides difficile Infection in Mice.
A novel pepper membrane-located receptor-like protein gene CaMRP1 is required for disease susceptibility, methyl jasmonate insensitivity and salt tolerance.
A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children.
Acute appendicitis: transcript profiling of blood identifies promising biomarkers and potential underlying processes.
Acute transcriptional response of the honeybee peptide-antibiotics gene repertoire and required post-translational conversion of the precursor structures.
Alpha Defensin Lateral Flow Test for Diagnosis of Periprosthetic Joint Infection: Not a Screening but a Confirmatory Test.
Alpha defensin, leukocyte esterase, C-reactive protein, and leukocyte count in synovial fluid for pre-operative diagnosis of periprosthetic infection.
Alpha-2-macroglobulin: A physiological guardian.
Amniotic fluid defensins: potential markers of subclinical intrauterine infection.
Antibacterial activity of human defensins on anaerobic intestinal bacterial species: a major role of HBD-3.
Antimicrobial peptide gene cecropin-2 and defensin respond to peptidoglycan infection in the female adult of oriental fruit fly, Bactrocera dorsalis (Hendel).
Antimicrobial peptides in burns and wounds.
Antimicrobial Peptides in Innate Immunity against Mycobacteria.
Antimicrobial Responses in the Male Reproductive Tract of Lipopolysaccharide Challenged Rats.
Arabidopsis thaliana plants differentially modulate auxin biosynthesis and transport during defense responses to the necrotrophic pathogen Alternaria brassicicola.
Bacterial feeding, Leishmania infection and distinct infection routes induce differential defensin expression in Lutzomyia longipalpis.
Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis.
Big defensins, a diverse family of antimicrobial peptides that follows different patterns of expression in hemocytes of the oyster Crassostrea gigas.
Blocking of Plasmodium transmission by cooperative action of Cecropin A and Defensin A in transgenic Aedes aegypti mosquitoes.
Cellular Response to Trypanosoma cruzi infection induces Secretion of Defensin ?-1, Which Damages the Flagellum, Neutralizes Trypanosome Motility and Inhibits Infection.
Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major.
Characterization of an endogenous gene expressed in Aedes aegypti using an orally infectious recombinant Sindbis virus.
Clinical Evaluation of Alpha Defensin Test Following Staged Treatment of Prosthetic Joint Infections.
Clinical Evaluation of Synovial Alpha Defensin and Synovial C-Reactive Protein in the Diagnosis of Periprosthetic Joint Infection.
Comparison of the Effects of Human ?-defensin 3, Vancomycin, and Clindamycin on Staphylococcus aureus Biofilm Formation.
Contribution of TLR2 pathway in the pathogenesis of vulvovaginal candidiasis.
Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer.
Cutaneous defense mechanisms by antimicrobial peptides.
Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms.
Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells.
Defensin from disk abalone Haliotis discus discus: molecular cloning, sequence characterization and immune response against bacterial infection.
Defensin gene family in Medicago truncatula: structure, expression and induction by signal molecules.
Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status.
Diagnostic Accuracy of the Alpha Defensin Lateral Flow Device (Synovasure™) for Periprosthetic Infections in Microbiologically Complex Situations: A Study of 42 Cases in a French Referral Centre.
Differential expression of ovine innate immune genes by preterm and neonatal lung epithelia infected with respiratory syncytial virus.
Differential regulation of beta-defensin gene expression during Cryptosporidium parvum infection.
Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions.
Drosophila melanogaster mounts a unique immune response to the Rhabdovirus sigma virus.
Effect of ions on antibacterial activity of human beta defensin 2.
Effect of larval density and Sindbis virus infection on immune responses in Aedes aegypti.
Endogenous production of antimicrobial peptides in innate immunity and human disease.
Evidence that the role of plant defensins in radish defense responses is independent of salicylic acid.
Expression of defensin, cecropin, and transferrin in Aedes aegypti (Diptera: Culicidae) infected with Wuchereria bancrofti (Spirurida: Onchocercidae), and the abnormal development of nematodes in the mosquito.
Gene organization of a novel defensin of Ixodes ricinus: first annotation of an intron/exon structure in a hard tick defensin gene and first evidence of the occurrence of two isoforms of one member of the arthropod defensin family.
Genome Wide Identification and Functional Prediction of Long Non-Coding RNAs Responsive to Sclerotinia sclerotiorum Infection in Brassica napus.
Ha-DEF1, a sunflower defensin, induces cell death in Orobanche parasitic plants.
High throughput profiling of the cotton bollworm Helicoverpa armigera immunotranscriptome during the fungal and bacterial infections.
High-Fidelity Point-of-Care Diagnostic Test for Periprosthetic Joint Infection: Commentary on an article by Thorsten Gehrke, MD, et al.: "The Accuracy of the Alpha Defensin Lateral Flow Device for Diagnosis of Periprosthetic Joint Infection. Comparison with a Gold Standard".
Human ?-defensin 3 increases the TLR9-dependent response to bacterial DNA.
Human ?-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes.
Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission.
Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy.
Human beta-defensin 2 is up-regulated during re-epithelialization of the cornea.
Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract.
Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction.
Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23.
Human enteric defensins. Gene structure and developmental expression.
Identification of an inhibitor of tissue-type plasminogen activator-mediated fibrinolysis in human neutrophils. A role for defensin.
Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae.
Immune responses in the haemolymph and antimicrobial peptide expression in the abdomen of Apis mellifera challenged with Spiroplasma melliferum CH-1.
Impaired immune defense in hemodialysis patients: Role of ?-defensins?
Improved diagnostic accuracy with the classification tree method for diagnosing low-grade periprosthetic joint infections by quantitative measurement of synovial fluid alpha-defensin and C-reactive protein.
Improved sulfur nutrition provides the basis for enhanced production of sulfur-containing defense compounds in Arabidopsis thaliana upon inoculation with Alternaria brassicicola.
Increased survivorship following bacterial infection by the mosquito Aedes aegypti as compared to Anopheles gambiae correlates with increased transcriptional induction of antimicrobial peptides.
Inducible immune factors of the vector mosquito Anopheles gambiae: biochemical purification of a defensin antibacterial peptide and molecular cloning of preprodefensin cDNA.
Infection: It's a Numbers Game: Commentary on an article by William Z. Stone, MD, et al.: "Clinical Evaluation of Synovial Alpha Defensin and Synovial C-Reactive Protein in the Diagnosis of Periprosthetic Joint Infection".
Innate response of human endothelial cells infected with mycobacteria.
Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization.
Is infection the possible initiator of disc disease? An insight from proteomic analysis.
Is the Enzyme-linked Immunosorbent Assay More Accurate Than the Lateral Flow Alpha Defensin Test for Diagnosing Periprosthetic Joint Infection?
Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila.
Microbicidal effects of ?- and ?-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa.
Modulation of HIV peptide antigen specific cellular immune response by synthetic ?- and ?-defensin peptides.
Mosquito-Plasmodium interactions in response to immune activation of the vector.
Neopterin, Interleukin-6, Procalcitonin, C-Reactive Protein And PET-CT Staining As Markers In Infected Total Knee Prosthesis, A Retrospective Analysis.
Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation.
NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation.
Non-oncologic applications of radiolabeled peptides in nuclear medicine.
Oesophageal defensin expression during Candida infection and reflux disease.
Parallel evolution of gene classes, but not genes: evidence from Hawai'ian honeycreeper populations exposed to avian malaria.
Pathogen blocking in Wolbachia-infected Aedes aegypti is not affected by Zika and dengue virus co-infection.
Plant defensins-Prospects for the biological functions and biotechnological properties.
Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis.
Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body.
Purification and antimicrobial properties of three defensins from rat neutrophils.
Reduced Gene Expression of Intestinal alpha -Defensins Predicts Diarrhea in a Cohort of African Adults.
Retrocyclin 2: a new therapy against avian influenza H5N1 virus in vivo and vitro.
Rickettsia peacockii, an endosymbiont of Dermacentor andersoni, does not elicit or inhibit humoral immune responses from immunocompetent D. andersoni or Ixodes scapularis cell lines.
Role of pathogen-induced volatiles in the Nicotiana tabacum-Golovinomyces cichoracearum interaction.
Silencing expression of the defensin, varisin, in male Dermacentor variabilis by RNA interference results in reduced Anaplasma marginale infections.
Ten questions on prosthetic shoulder infection.
The Accuracy of the Alpha Defensin Lateral Flow Device for Diagnosis of Periprosthetic Joint Infection: Comparison with a Gold Standard.
The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
The effect of Botrytis cinerea infection on the antioxidant profile of mitochondria from tomato leaves.
The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets.
The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid.
The Mediator subunit SFR6/MED16 controls defence gene expression mediated by salicylic acid and jasmonate responsive pathways.
The noa gene is functionally linked to the activation of the Toll/Imd signaling pathways in Bactrocera dorsalis (Hendel).
The Putative Role of Human Peritoneal Adipocytes in the Fight against Bacteria: Synthesis of the Antimicrobial Active Peptide DEFA1-3.
The role of alpha defensin in prosthetic joint infection (PJI) diagnosis: a literature review.
The role of biomarkers in the diagnosis of periprosthetic joint infection.
The Role of IL-17 and Related Cytokines in Inflammatory Autoimmune Diseases.
The role of NF-kappaB factor REL2 in the Aedes aegypti immune response.
The signature of long-standing balancing selection at the human defensin beta-1 promoter.
Therapeutic effect of modified oligopeptides from the beetle Allomyrina dichotoma on methicillin-resistant Staphylococcus aureus (MRSA) infection in mice.
Trypanosoma cruzi Infection Modulates the Expression of Triatoma brasiliensis def1 in the Midgut.
Tsetse immune responses and trypanosome transmission: implications for the development of tsetse-based strategies to reduce trypanosomiasis.
Two-stage revision and systemic antifungal therapy of Candida glabrata primary prosthetic hip infection successfully treated: a case report.
Up-regulation of the ascorbate-dependent antioxidative system in barley leaves during powdery mildew infection.
Uropathogenic Escherichia coli (UPEC) induced antimicrobial gene expression in the male reproductive tract of rat: evaluation of the potential of Defensin 21 to limit infection.
[Construction and identification of HBD-2 transgenic mice]
[Effect of human beta defensin 2 on Staphylococcus aureus infection: in vivo study with transgenic mice]
[Nephrology-part 3: Urinary tract infections]
Infertility
A Common Mutation in the Defensin DEFB126 Causes Impaired Sperm Function and Subfertility.
Male factor infertility: Mutation of sperm defensin causes subfertility.
Re: a common mutation in the defensin DEFB126 causes impaired sperm function and subfertility.
Inflammatory Bowel Diseases
A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion.
Antimicrobial Peptides and Colitis.
Correction: Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease.
Defensins and inflammation: the role of defensins in inflammatory bowel disease.
Defensins and Paneth cells in inflammatory bowel disease.
Esophageal human ?-defensin expression in eosinophilic esophagitis.
Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease.
Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease.
NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation.
Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa.
Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo.
Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population.
Influenza in Birds
Retrocyclin 2: a new therapy against avian influenza H5N1 virus in vivo and vitro.
Influenza, Human
A Kampo (traditional Japanese herbal) medicine, Hochuekkito, pretreatment in mice prevented influenza virus replication accompanied with GM-CSF expression and increase in several defensin mRNA levels.
Intestinal Diseases
High-level expression, purification and characterisation of porcine ?-defensin 2 in Pichia pastoris and its potential as a cost-efficient growth promoter in porcine feed.
Keratitis
Defensin gene expression in the cornea.
Immune Defense Single Nucleotide Polymorphisms and Recruitment Strategies Associated with Contact Lens Keratitis.
Kidney Calculi
Characterization of the Protein Components of Matrix Stones Sheds Light on S100-A8 and S100-A9 Relevance in the Inflammatory Pathogenesis of These Rare Renal Calculi.
Leishmaniasis
Bacterial feeding, Leishmania infection and distinct infection routes induce differential defensin expression in Lutzomyia longipalpis.
The sandfly Lutzomyia longipalpis LL5 embryonic cell line has active Toll and Imd pathways and shows immune responses to bacteria, yeast and Leishmania.
Leptospirosis
Urine Levels of Defensin ?1 Reflect Kidney Injury in Leptospirosis Patients.
Leukemia
Assessment of the cellular response to the induced expression of defensin sense and antisense cDNA in acute promyelocytic leukemia cell lines.
Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells.
Drug-activated multiple pathways of defensin mRNA regulation in HL-60 cells are defined by reversed roles of participating protein kinases.
Isolation and characterization of human defensin cDNA clones.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
PaDef defensin from avocado (Persea americana var. drymifolia) is cytotoxic to K562 chronic myeloid leukemia cells through extrinsic apoptosis.
Posttranslational processing of defensins in immature human myeloid cells.
Leukemia, Myeloid
Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells.
Leukemia, Promyelocytic, Acute
Assessment of the cellular response to the induced expression of defensin sense and antisense cDNA in acute promyelocytic leukemia cell lines.
Lung Diseases
Diesel exhaust particles increase IL-1beta-induced human beta-defensin expression via NF-kappaB-mediated pathway in human lung epithelial cells.
Implication of vitamin D-associated factors in patients with non-tuberculous mycobacterial lung disease.
Role of defensins in inflammatory lung disease.
Lung Diseases, Obstructive
Antimicrobial peptide defensin: identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases.
Lung Neoplasms
Aptamers Selected to Postoperative Lung Adenocarcinoma Detect Circulating Tumor Cells in Human Blood.
Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study.
In Vitro and In Vivo Anticancer Activity of Human ?-Defensin-3 and Its Mouse Homolog.
Lupus Erythematosus, Systemic
Cardiovascular disease and serum defensin levels in systemic lupus erythematosus.
Lyme Disease
An arthropod defensin expressed by the hemocytes of the American dog tick, Dermacentor variabilis (Acari: Ixodidae).
Defensin from the ornate sheep tick Dermacentor marginatus and its effect on Lyme borreliosis spirochetes.
Lymphoma
Selenium Deficiency Aggravates Aflatoxin B1-Induced Immunotoxicity in Chick Spleen by Regulating 6 Selenoprotein Genes and Redox/Inflammation/Apoptotic Signaling.
Malaria
Molecular and phylogenetic analysis of a novel salivary defensin cDNA from malaria vector Anopheles stephensi.
Parallel evolution of gene classes, but not genes: evidence from Hawai'ian honeycreeper populations exposed to avian malaria.
The defensin peptide of the malaria vector mosquito Anopheles gambiae: antimicrobial activities and expression in adult mosquitoes.
The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes.
Melanoma
Expression of Antimicrobial Peptides by Uveal and Cutaneous Melanoma Cells and Investigation of Their Role in Tumor Cell Migration and Vasculogenic Mimicry.
Prevalent Homozygous Deletions of Type I Interferon and Defensin Genes in Human Cancers Associate with Immunotherapy Resistance.
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
Meningitis
Levels of antimicrobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis.
Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis.
Meningitis, Aseptic
Levels of antimicrobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis.
Meningitis, Bacterial
Levels of antimicrobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis.
Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis.
monodehydroascorbate reductase (nadh) deficiency
A marked decrease in defensin mRNA in the only case of congenital neutrophil-specific granule deficiency reported in Japan.
A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion.
Abnormal peroxidase-positive granules in "specific granule" deficiency.
Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease.
Crohn's disease: a defensin deficiency syndrome?
Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.
Defensin-immunology in inflammatory bowel disease.
Defensins and inflammation: the role of defensins in inflammatory bowel disease.
Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion.
Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease.
Innate immune defenses in the intestinal tract.
NOD2 and defensins: translating innate to adaptive immunity in Crohn's disease.
Paneth cell defensins and the regulation of the microbiome: Détente at mucosal surfaces.
[The role of defensins in the pathogenesis of chronic-inflammatory bowel disease]
Mycoses
Anti-leishmanial activity of Brevinin 2R and its Lauric acid conjugate type against L. major: In vitro mechanism of actions and in vivo treatment potentials.
Enhanced resistance to Sclerotinia sclerotiorum in Brassica napus by co-expression of defensin and chimeric chitinase genes.
Evidence that the role of plant defensins in radish defense responses is independent of salicylic acid.
Extensive differences in antifungal immune response in two Drosophila species revealed by comparative transcriptome analysis.
Integrated transcriptomic and metabolomic analyses of a wax deficient citrus mutant exhibiting jasmonic acid-mediated defense against fungal pathogens.
Resistance to the Plant Defensin NaD1 Features Modifications to the Cell Wall and Osmo-Regulation Pathways of Yeast.
The limpet transcription factors of Triatoma infestans regulate the response to fungal infection and modulate the expression pattern of defensin genes.
Transgenic tobacco and peanut plants expressing a mustard defensin show resistance to fungal pathogens.
Nasal Polyps
Expression of antiviral molecular genes in nasal polyp-derived cultured epithelial cells.
Neonatal Sepsis
Pathological Role and Diagnostic Value of Endogenous Host Defense Peptides in Adult and Neonatal Sepsis: A Systematic Review.
Neoplasms
Aster glehni Extract Containing Caffeoylquinic Compounds Protects Human Keratinocytes through the TRPV4-PPAR?-AMPK Pathway.
cDNA microarray analysis of differential gene expression in gastric cancer cells sensitive and resistant to 5-Fluorouracil and Cisplatin.
Comparison of IL-1?, TNF-?, hBD-2, and hBD-3 Expression in the Dental Pulp of Smokers Versus Nonsmokers.
Construction and characterization of a recombinant human beta defensin 2 fusion protein targeting the epidermal growth factor receptor: in vitro study.
Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients.
Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells.
Defensins: "Simple" antimicrobial peptides or broad-spectrum molecules?
Differential innate immune responses of a living skin equivalent model colonized by Staphylococcus epidermidis or Staphylococcus aureus.
Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells.
Effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on mouse peritoneal macrophages stimulated with lipopolysaccharide.
Expression of Antimicrobial Peptides by Uveal and Cutaneous Melanoma Cells and Investigation of Their Role in Tumor Cell Migration and Vasculogenic Mimicry.
Expression of defensin antimicrobial peptides in the peritoneal cavity of patients on peritoneal dialysis.
Expressions of beta-defensins in human keratinocyte cell lines.
Functional intersection of Human Defensin 5 with the TNF receptor pathway.
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
High-resolution mapping of the 8p23.1 beta-defensin cluster reveals strictly concordant copy number variation of all genes.
Human ?-defensin 3 contains an oncolytic motif that binds PI(4,5)P2 to mediate tumour cell permeabilisation.
Human Beta Defensins and Cancer: Contradictions and Common Ground.
Identification of defensin alpha6 as a potential biomarker in colon adenocarcinoma.
Impact of Herpes Simplex Virus Type 2 and Human Immunodeficiency Virus Dual Infection on Female Genital Tract Mucosal Immunity and the Vaginal Microbiome.
Local antimicrobial, protease and cytokine defense systems in psoriatic skin.
Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion.
Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumour cell killing and an enhanced antifungal variant.
Oncogenic relevant defensins: expression pattern and proliferation characteristics of human tumor cell lines.
Phosphoinositide-mediated oligomerization of a defensin induces cell lysis.
Presence of defensin in epithelial Langerhans cells adjacent to oral carcinomas and precancerous lesions.
Prevalent Homozygous Deletions of Type I Interferon and Defensin Genes in Human Cancers Associate with Immunotherapy Resistance.
Probiotics and Their Use in Inflammatory Bowel Disease.
Protease-activated receptor-2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to Propionibacterium acnes.
Protective effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on endotoxic shock in mice.
Stressors Due to Handling Impair Gut Immunity in Meagre (Argyrosomus regius): The Compensatory Role of Dietary L-Tryptophan.
Structural and functional characterization of the membrane-permeabilizing activity of Nicotiana occidentalis defensin NoD173 and protein engineering to enhance oncolysis.
Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial.
The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila.
The defensin from avocado (Persea americana var. drymifolia) PaDef induces apoptosis in the human breast cancer cell line MCF-7.
The plant defensin NaD1 induces tumor cell death via a non-apoptotic, membranolytic process.
The Tomato Defensin TPP3 Binds Phosphatidylinositol (4,5)-Bisphosphate via a Conserved Dimeric Cationic Grip Conformation To Mediate Cell Lysis.
[Effects of human defensin HNP-1 on the production of tumor necrosis factor-alpha by human blood monocytes in vitro]
[The antiangiogenic effect of DNA vaccine based on beta-defensin 2 fused with VE-cadherin]
Neuroblastoma
Ascorbic acid recycling in N-myc amplified human neuroblastoma cells.
Obstetric Labor, Premature
Amniotic fluid defensins: potential markers of subclinical intrauterine infection.
Human ?-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes.
Onchocerciasis
Human autoantibody to defensin: disease association with hyperreactive onchocerciasis (sowda).
Onychomycosis
Morphopathological aspects of healthy nails and nails affected by onychomycosis.
Triintsin, a human pathogenic fungus-derived defensin with broad-spectrum antimicrobial activity.
Opportunistic Infections
Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: high-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls.
Otitis Media
Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.
Pancreatitis, Chronic
Association studies of the copy-number variable ß-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis.
Paramyxoviridae Infections
Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs.
Parasitemia
Antiplasmodial activity of tick defensins in a mouse model of malaria.
Parasitic Diseases
Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major.
Peri-Implantitis
Levels and molecular forms of MMP-7 (matrilysin-1) and MMP-8 (collagenase-2) in diseased human peri-implant sulcular fluid.
Periodontal Diseases
Human beta defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases.
Reduced human beta defensin 3 in individuals with periodontal disease.
The Human Salivary Antimicrobial Peptide Profile according to the Oral Microbiota in Health, Periodontitis and Smoking.
Periodontitis
Beta-sheet antibiotic peptides as potential dental therapeutics.
The Antimicrobial Peptide DEFB1 is Associated with Caries.
Two Cheers for Crohn's Disease and Periodontitis: Beta-Defensin-2 as an Actionable Target to Intervene on Two Clinically Distinct Diseases.
Peritonitis
Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation.
Secondary peritonitis: severity of disease and activation of peritoneal cells.
Pituitary Neoplasms
Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines.
Plant Diseases
TaMDHAR4, a monodehydroascorbate reductase gene participates in the interactions between wheat and Puccinia striiformis f. sp. tritici.
The proteins of plant defensin family and their application beyond plant disease control.
[Biological characteristics of defensin and its disease-resistance genetic engineering].
Pneumonia
Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs.
Polyomavirus Infections
The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid.
Pouchitis
Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli.
Innate immune environment in ileal pouch mucosa: ?5 defensin up-regulation as predictor of chronic/relapsing pouchitis.
Prostatic Neoplasms
Genetic variants of the copy number polymorphic beta-defensin locus are associated with sporadic prostate cancer.
Whole blood defensin mRNA expression is a predictive biomarker of docetaxel response in castration-resistant prostate cancer.
Pseudomonas Infections
Blocking of Plasmodium transmission by cooperative action of Cecropin A and Defensin A in transgenic Aedes aegypti mosquitoes.
Psoriasis
Antimicrobial peptide defensin: identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases.
Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin.
Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes.
Defensin-barbed innate immunity: clinical associations in the pediatric population.
Local antimicrobial, protease and cytokine defense systems in psoriatic skin.
Mechanism of HBD-3 deficiency in atopic dermatitis.
Resident T cells in resolved psoriasis steer tissue responses that stratify clinical outcome.
Pulmonary Disease, Chronic Obstructive
Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects.
Genetic linkage and association analysis of COPD-related traits on chromosome 8p.
Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells.
Increased Expression of Beta-Defensin 1 (DEFB1) in Chronic Obstructive Pulmonary Disease.
Pulmonary Eosinophilia
Elevated levels of antimicrobial peptides in bronchoalveolar lavage fluid in patients with chronic eosinophilic pneumonia.
Renal Insufficiency
The interaction of urinary tract infection and renal insufficiency.
Respiratory Distress Syndrome, Adult
Diesel exhaust particles increase IL-1beta-induced human beta-defensin expression via NF-kappaB-mediated pathway in human lung epithelial cells.
Role of defensins in inflammatory lung disease.
[Defensin in plasma and in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome]
Respiratory Tract Infections
Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study.
Rhinitis, Allergic
Esophageal human ?-defensin expression in eosinophilic esophagitis.
Salivary Gland Calculi
Proteomic and scanning electron microscopic analysis of submandibular sialoliths.
Salmonella Infections
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin.
Salmonella serovar specific upregulation of porcine defensins 1 and 2 in a jejunal epithelial cell line.
Sepsis
Antimicrobial peptide defensin: identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases.
Antimicrobial peptides in burns and wounds.
Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein.
Pathological Role and Diagnostic Value of Endogenous Host Defense Peptides in Adult and Neonatal Sepsis: A Systematic Review.
Plasma concentrations of defensins and lactoferrin in children with severe sepsis.
Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis.
The signature of long-standing balancing selection at the human defensin beta-1 promoter.
Sexually Transmitted Diseases
Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions.
Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission.
Shock, Septic
Protective effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on endotoxic shock in mice.
Staphylococcal Infections
[Effect of human beta defensin 2 on Staphylococcus aureus infection: in vivo study with transgenic mice]
Starvation
Larval environmental stress alters Aedes aegypti competence for Sindbis virus.
Stomatitis, Aphthous
Increased beta 2 defensin in recurrent aphthous ulcer.
Sunburn
Photoprotection mechanism in the 'Fuji' apple peel at different levels of photooxidative sunburn.
Superinfection
IL-33 Modulates the Expression of Human Beta Defensin 2 in Human Primary Keratinocytes and may influence the susceptibility to bacterial superinfection in acute atopic dermatitis.
Tick-Borne Diseases
[Changes of functional activity of peripheral blood leukocytes during the immunotherapy of tick-borne infections in children].
Tinea Capitis
Trichophyton tonsurans-induced kerion celsi with decreased defensin expression and paradoxically increased interleukin-17A production.
Tonsillitis
A newly discovered function of palatine tonsils in immune defence: the expression of defensins.
Chronic tonsillitis is not associated with beta defensin 1 gene polymorphisms in Turkish population.
Expression and Localization of Human Defensins in Palatine Tonsils.
Trichomonas Infections
Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy.
Tuberculosis
Expressions of Antimicrobial Peptides LL-37, Human Beta Defensin-2 and -3 in the Lesions of Cutaneous Tuberculosis and Tuberculids.
Hypoxia triggers the expression of human ? defensin 2 and antimicrobial activity against Mycobacterium tuberculosis in human macrophages.
Innate response of human endothelial cells infected with mycobacteria.
Tuberculosis, Pulmonary
Expression of Beta defensin 2 in experimental pulmonary tuberculosis: tentative approach for vaccine development.
[Association between human beta defensin-1 single nucleotide polymorphisms and susceptibility to pulmonary tuberculosis].
Typhoid Fever
PhoP/PhoQ: macrophage-specific modulators of Salmonella virulence?
Urethritis
Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions.
Urinary Bladder Neoplasms
Development of a novel proteomic approach for the detection of transitional cell carcinoma of the bladder in urine.
Urinary Tract Infections
A Murine Model of Inflammatory Bladder Disease: Cathelicidin Peptide Induced Bladder Inflammation and Treatment With Sulfated Polysaccharides.
Uterine Cervical Neoplasms
Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer.
Uterine Cervicitis
[Study on vaginal production of human defensins and the correlated pathogenetic factors of vulvovaginal candidiasis]
Uterine Hemorrhage
Bacterial vaginosis, vaginal fluid neutrophil defensins, and preterm birth.
Uveitis
Immunohistochemical localization of T lymphocytes and macrophages and expression of interferon gamma and defensin in uveitis.
Vaginal Discharge
[Study on vaginal production of human defensins and the correlated pathogenetic factors of vulvovaginal candidiasis]
Vaginosis, Bacterial
Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis.
Bacterial Colonization and Beta Defensins in the Female Genital Tract in HIV Infection.
Bacterial vaginosis and vaginal fluid defensins during pregnancy.
Human defensins and cytokines in vaginal lavage fluid of women with bacterial vaginosis.
Midpregnancy vaginal fluid defensins, bacterial vaginosis, and risk of preterm delivery.
Virus Diseases
Characterization of an endogenous gene expressed in Aedes aegypti using an orally infectious recombinant Sindbis virus.
Defensin gene variation and HIV/AIDS: a comprehensive perspective needed.
Defensins in Viral Infection and Pathogenesis.
Defensins in viral infections.
DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy.
Vitamin A Deficiency
Bacterial population and innate immunity-related genes in rat gastrointestinal tract are altered by vitamin A-deficient diet.
Whooping Cough
The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets.
Yellow Fever
Antibacterial peptides in insect vectors of tropical parasitic disease.
Zoonoses
Avian defensins.