Any feedback?
Information on EC 2.7.4.6 - nucleoside-diphosphate kinase
for references in articles please use BRENDA:EC2.7.4.6Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
2.7.4.6 nucleoside-diphosphate kinaseIUBMB Comments
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.
Specify your search results
Word Map
- 2.7.4.6
- triphosphate
- node
- gdp
- lymph
- adenylate
- metastases
- tumour
- autophosphorylation
- colorectal
- oncogene
- drosophila
- guanine
- c-myc
-
clinicopathological
- melanoma
- creatine
- dictyostelium
-
hexameric
-
gtp-binding
- discoideum
-
non-metastatic
-
gamma-phosphate
-
anti-metastatic
-
heterotrimeric
-
phosphohistidine
-
transphosphorylation
- dntp
- deoxyribonucleoside
- succinyl-coa
- phosphoenzyme
-
metastasis-related
- mastoparan
-
high-metastatic
-
metastasis-associated
-
prune
-
c-erbb-2
- myxococcus
-
g-quadruplexes
- deoxynucleoside
- xanthus
- medicine
- drug development
The enzyme appears in viruses and cellular organisms
Synonyms
nm23-h1, nucleoside diphosphate kinase, ndp kinase, nm23-h2, ndpk-b, ndpk2, nucleoside diphosphokinase, ndk-1, nucleoside-diphosphate kinase, nucleoside diphosphate kinase a, 
more
topREACTION 
REACTION DIAGRAM
COMMENTARY 
ORGANISM
UNIPROT
LITERATURE
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
mechanism
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
overview on mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors
-
-
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
mechanism, role of 3-OH moiety of nucleotide
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the catalytic mechanism involves a phosphoenzyme intermediate
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
phosphoenzyme intermediate with 2-4 mol phosphate per mol of enzyme
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
phosphoenzyme intermediate with 2-4 mol phosphate per mol of enzyme
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
phosphoenzyme intermediate with 2-4 mol phosphate per mol of enzyme
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
two-step ping-pong mechanism
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
isozyme NDPKB shows a ping-pong phospho-transfer mechanism, salt and nucleotide dependent NDPKB assembly is dynamic and requires its catalytic activity
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
ping pong mechanism with formation of an enzyme intermediate phosphorylated at His118
-
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
ping pong mechanism with formation of an enzyme intermediate phosphorylated at His118
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
the reaction catalyzed by NDK starts with the transfer of a phosphate from ATP to His117. ADP is then released and the acceptor nucleoside diphosphate is bound and phosphorylated. Nucleotide phosphates are coordinated by a network of basic Arg and His residues, and a polar Thr. All NDKs follow a ping-pong enzymatic mechanism involving a phosphorylated histidine residue in the active site
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
two-step ping-pong mechanism
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
PATHWAY SOURCE
PATHWAYS
KEGG
-
, , Biosynthesis of secondary metabolites, Drug metabolism - other enzymes, Drug metabolism - other enzymes, Drug metabolism - other enzymes, Drug metabolism - other enzymes, non-pathway related, non-pathway related, purine metabolism, purine metabolism, purine metabolism, purine metabolism, purine metabolism, purine metabolism, pyrimidine metabolism, pyrimidine metabolism