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BRENDA support

Information on EC 3.1.1.116 - sn-1-specific diacylglycerol lipase

for references in articles please use BRENDA:EC3.1.1.116

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IUBMB Comments

The enzyme, present in animals, is specific for the sn-1 position. When acting on 1-acyl-2-arachidonoyl-sn-glycerol, the enzyme forms 2-arachidonoylglycerol, the most abundant endocannabinoid in the mammalian brain.

The enzyme appears in viruses and cellular organisms
Reaction Schemes

Synonyms
dagla, dg lipase, daglalpha, diacylglycerol lipase alpha, daglb, diacylglycerol lipase-alpha, daglbeta, diacylglycerol lipase beta, sn-1-specific lipase, sn-1-specific diacylglycerol lipase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links