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Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphtylamine
assay at 37°C, pH 8.0
-
-
?
Ala-Ala-2-naphtylamide + H2O
Ala-Ala + 2-naphthylamine
Ala-Ala-Ala-Ala + H2O
Ala-Ala + Ala-Ala
-
action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
-
-
?
Ala-Ala-beta-naphthylamide + H2O
Ala-Ala + beta-naphthylamine
-
10.0% activity
-
-
?
Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
Ala-Arg-2-naphtylamide + H2O
Ala-Arg + 2-naphthylamine
Ala-Phe-2-naphthylamide + H2O
Ala-Phe + 2-naphthylamine
-
-
-
?
Ala-Phe-2-naphthylamide + H2O
Ala-Phe + 2-naphtylamine
assay at 37°C, pH 8.0
-
-
?
angiotensin II + H2O
Asp-Arg + Val-Tyr + Ile-His + Pro-Phe
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Arg-Arg-2-naphtylamide + H2O
Arg-Arg + 2-naphthylamine
Arg-Arg-4-methoxy-2-naphthylamide + H2O
Arg-Arg + 4-methoxy-2-naphthylamine
Arg-Arg-4-methoxy-beta-naphthylamide + H2O
Arg-Arg + 4-methoxy-beta-naphthylamine
-
activity assay, 100% activity
-
-
?
Arg-Arg-4-methylcoumarin 7-amide + H2O
Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Arg-Arg-7-amido-4 methylcoumarin + H2O
?
-
-
-
-
?
Arg-Arg-7-amido-4-methylcoumarin + H2O
Arg-Arg + 7-amino-4-methylcoumarin
-
assay at 37°C
-
-
?
Arg-Arg-beta-naphthylamide + H2O
Arg-Arg + beta-naphthylamine
-
-
-
-
?
Arg-Arg-naphthylamide + H2O
?
-
substrate used in the activity assay
-
-
?
Arg-Tyr-Leu-Pro-Thr + H2O
Arg-Tyr + Leu-Pro-Thr
Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + H2O
?
-
angiotensin III, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
-
-
?
arginyl-arginyl-4-methoxy-beta-naphthylamide + H2O
Arg-Arg + 4-methoxy-beta-naphthylamine
-
substrate used in the activity assay
-
-
?
Asp-Ala-beta-naphthylamide + H2O
Asp-Ala + beta-naphthylamine
-
0% activity
-
-
?
Asp-Arg-beta-naphthylamide + H2O
Asp-Arg + beta-naphthylamine
-
1.5% activity
-
-
?
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe + H2O
?
-
angiotensin II, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
-
-
?
DRVYIHPF + H2O
IHPF + ?
i.e. angiotensin II
-
-
?
enkephalin + H2O
?
-
-
-
-
?
Gly-Ala-beta-naphthylamide + H2O
Gly-Ala + beta-naphthylamine
-
3.2% activity
-
-
?
Gly-Arg-2-naphthylamide + H2O
Gly-Arg + 2-naphthylamine
-
-
-
?
Gly-Arg-2-naphtylamide + H2O
Gly-Arg + 2-naphthylamine
Gly-Arg-beta-naphthylamide + H2O
Gly-Arg + beta-naphthylamine
Gly-Gly-Phe-Leu + H2O
?
-
-
-
-
?
Gly-Phe-2-naphthylamide + H2O
Gly-Phe + 2-naphthylamine
assay at 37°C, pH 8.0
-
-
?
Gly-Phe-beta-naphthylamide + H2O
Gly-Phe + beta-naphthylamine
-
2.4% activity
-
-
?
Gly-Pro-4-methoxy-beta-naphthylamide + H2O
Gly-Pro + 4-methoxy-beta-naphthylamine
-
0% activity
-
-
?
His-Phe-beta-naphthylamide + H2O
His-Phe + beta-naphthylamine
-
0% activity
-
-
?
His-Ser-2-naphthylamide + H2O
His-Ser + 2-naphthylamine
-
-
-
?
His-Ser-beta-naphthylamide + H2O
His-Ser + beta-naphthylamine
-
0% activity
-
-
?
IVYPW + H2O
YPW + ?
-
-
-
?
L-Ala-L-Ala 2-naphthylamide + H2O
L-Ala-L-Ala + 2-naphthylamine
-
-
-
?
L-Ala-L-Ala-2-naphthylamide + H2O
L-Ala-L-Ala + 2-naphthylamine
-
36.64% of the activiy with L-Arg-L-Arg-4-methoxy-2-naphthylamide
-
-
?
L-Arg-L-Arg 2-naphthylamide + H2O
L-Arg-L-Arg + 2-naphthylamine
-
-
-
?
L-Arg-L-Arg-2-naphthylamide + H2O
L-Arg-L-Arg + 2-naphthylamine
L-Arg-L-Arg-4-methoxy-2-naphthylamide + H2O
L-Arg-L-Arg + 4-methoxy-2-naphthylamine
L-Asp-L-Ala-2-naphthylamide + H2O
L-Asp-L-Ala + 2-naphthylamine
-
8.67% of the activiy with L-Arg-L-Arg-4-methoxy-2-naphthylamide
-
-
?
L-Asp-L-Arg-2-naphthylamide + H2O
L-Asp-L-Arg + 2-naphthylamine
-
9.8% of the activiy with L-Arg-L-Arg-4-methoxy-2-naphthylamide
-
-
?
L-His-L-Ser-4-methoxy-2-naphthylamide + H2O
L-His-L-Ser + 4-methoxy-2-naphthylamine
-
58.46% of the activiy with L-Arg-L-Arg-4-methoxy-2-naphthylamide
-
-
?
L-Lys-L-Ala-2-naphthylamide + H2O
L-Lys-L-Ala + 2-naphthylamine
-
activity of the cupric derivative for Lys-Ala-beta-naphthylamide is about 30% of that of the wild-type enzyme
-
-
?
L-Ser-L-Tyr-2-naphthylamide + H2O
L-Ser-L-Tyr + 2-naphthylamine
-
7.35% of the activiy with L-Arg-L-Arg-4-methoxy-2-naphthylamide
-
-
?
Leu-Ala-beta-naphthylamide + H2O
Leu-Ala + beta-naphthylamine
-
5.0% activity
-
-
?
Leu-enkephalin + H2O
Tyr-Gly + Gly-Phe-Leu
Leu-Gly-2-naphthylamide + H2O
Leu-Gly + 2-naphthylamine
Lys-Ala-2-naphthylamide + H2O
Lys-Ala + 2-naphthylamine
Lys-Ala-4-methoxy-2-naphthylamide + H2O
Lys-Ala + 4-methoxy-2-naphthylamine
Lys-Ala-4-methoxy-beta-naphthylamide + H2O
Lys-Ala + 4-methoxy-beta-naphthylamine
-
5.0% activity
-
-
?
Lys-Arg-2-naphtylamide + H2O
Lys-Arg + 2-naphthylamine
-
-
-
-
?
Lys-Arg-beta-naphthylamide + H2O
Lys-Arg + beta-naphthylamine
-
8% of the activity with Arg-Arg-beta-naphthylamide
-
-
?
Met-Arg-Phe-Ala + H2O
Met-Arg + Phe-Ala
-
-
-
?
Met-enkephalin + H2O
?
-
-
-
-
?
Phe-Arg-2-naphthylamide + H2O
Phe-Arg + 2-naphthylamine
Phe-Arg-2-naphtylamide + H2O
Phe-Arg + 2-naphthylamine
Phe-Arg-beta-naphthylamide + H2O
Phe-Arg + beta-naphthylamine
-
17.6% activity
-
-
?
Pro-Arg-2-naphthylamide + H2O
Pro-Arg + 2-naphthylamine
Pro-Arg-2-naphtylamide + H2O
Pro-Arg + 2-naphthylamine
143% of the activity with Arg-Arg-2-naphtylamide
-
-
?
proctolin + H2O
Arg-Tyr + Leu-Pro-Thr
-
-
-
?
proctolin + H2O
Tyr-Leu + ?
-
-
-
-
?
Ser-Met-beta-naphthylamide + H2O
Ser-Met + beta-naphthylamine
-
0% activity
-
-
?
Ser-Tyr-beta-naphthylamide + H2O
Ser-Tyr + beta-naphthylamine
-
0% activity
-
-
?
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly + H2O
?
-
ACTH, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
-
-
?
Trp-Met-Asp-Phe-NH2 + H2O
?
-
-
-
-
?
Trp-Met-Asp-Phe-NH2 + H2O
Trp-Met + Asp-Phe-NH2
-
gastrin tetrapeptide amide, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
-
-
?
Tyr-Gly-Gly-Phe + H2O
Tyr-Gly + Gly-Phe
Tyr-Gly-Gly-Phe-Leu + H2O
Tyr-Gly + Gly-Phe-Leu
Tyr-Gly-Gly-Phe-Met + H2O
?
-
-
-
?
Tyr-Pro-Trp-Phe-NH2 + H2O
Tyr-Pro + Trp-Phe-NH2
-
endomorphin-1
-
-
?
VVYPW + H2O
YPW + ?
i.e. tynorphin
-
-
?
additional information
?
-
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
-
-
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
-
-
-
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
-
poor substrate
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
-
-
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
-
poor substrate
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
-
-
-
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
-
-
-
?
Ala-Ala-2-naphtylamide + H2O
Ala-Ala + 2-naphthylamine
103% of the activity with Arg-Arg-2-naphtylamide
-
-
?
Ala-Ala-2-naphtylamide + H2O
Ala-Ala + 2-naphthylamine
103% of the activity with Arg-Arg-2-naphtylamide
-
-
?
Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
-
-
-
?
Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
-
-
-
-
?
Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
poor substrate
-
-
?
Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
-
-
-
?
Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
-
-
-
?
Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
-
-
-
-
?
Ala-Arg-2-naphtylamide + H2O
Ala-Arg + 2-naphthylamine
65% of the activity with Arg-Arg-2-naphtylamide
-
-
?
Ala-Arg-2-naphtylamide + H2O
Ala-Arg + 2-naphthylamine
65% of the activity with Arg-Arg-2-naphtylamide
-
-
?
angiotensin II + H2O
Asp-Arg + Val-Tyr + Ile-His + Pro-Phe
-
-
-
-
?
angiotensin II + H2O
Asp-Arg + Val-Tyr + Ile-His + Pro-Phe
-
-
-
-
?
angiotensin II + H2O
Asp-Arg + Val-Tyr + Ile-His + Pro-Phe
-
-
-
-
?
angiotensin II + H2O
Asp-Arg + Val-Tyr + Ile-His + Pro-Phe
-
-
-
-
?
angiotensin II + H2O
Asp-Arg + Val-Tyr + Ile-His + Pro-Phe
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
preferred substrate
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
substrate used in the activity assay
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
substrate used in the activity assay
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
assay at 37°C, pH 8.0
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
assay at pH 8.0, 37°C
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Schistosoma sp.
-
-
-
-
?
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
-
?
Arg-Arg-2-naphtylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-2-naphtylamide + H2O
Arg-Arg + 2-naphthylamine
-
-
-
?
Arg-Arg-4-methoxy-2-naphthylamide + H2O
Arg-Arg + 4-methoxy-2-naphthylamine
-
-
-
-
?
Arg-Arg-4-methoxy-2-naphthylamide + H2O
Arg-Arg + 4-methoxy-2-naphthylamine
-
-
-
-
?
Arg-Arg-4-methoxy-2-naphthylamide + H2O
Arg-Arg + 4-methoxy-2-naphthylamine
-
-
-
-
?
Arg-Tyr-Leu-Pro-Thr + H2O
Arg-Tyr + Leu-Pro-Thr
-
-
-
?
Arg-Tyr-Leu-Pro-Thr + H2O
Arg-Tyr + Leu-Pro-Thr
-
-
-
?
Arg-Tyr-Leu-Pro-Thr + H2O
Arg-Tyr + Leu-Pro-Thr
-
i.e. proctolin
-
?
Gly-Arg-2-naphtylamide + H2O
Gly-Arg + 2-naphthylamine
167% of the activity with Arg-Arg-2-naphtylamide
-
-
?
Gly-Arg-2-naphtylamide + H2O
Gly-Arg + 2-naphthylamine
167% of the activity with Arg-Arg-2-naphtylamide
-
-
?
Gly-Arg-beta-naphthylamide + H2O
Gly-Arg + beta-naphthylamine
-
11.8% activity
-
-
?
Gly-Arg-beta-naphthylamide + H2O
Gly-Arg + beta-naphthylamine
-
6.1% of the activity with Arg-Arg-beta-naphthylamide
-
-
?
L-Arg-L-Arg-2-naphthylamide + H2O
L-Arg-L-Arg + 2-naphthylamine
binding free energy calculations reveal tighter binding of the preferred synthetic substrate Arg-Arg-2-naphtylamide to the closed than to the open enzyme conformation. The electrostatic component of the free energy of solvation is higher for the closed protein than for its less compact form
-
-
?
L-Arg-L-Arg-2-naphthylamide + H2O
L-Arg-L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-L-Arg-4-methoxy-2-naphthylamide + H2O
L-Arg-L-Arg + 4-methoxy-2-naphthylamine
-
-
-
-
?
L-Arg-L-Arg-4-methoxy-2-naphthylamide + H2O
L-Arg-L-Arg + 4-methoxy-2-naphthylamine
-
-
-
-
?
Leu-enkephalin + H2O
Tyr-Gly + Gly-Phe-Leu
-
-
-
?
Leu-enkephalin + H2O
Tyr-Gly + Gly-Phe-Leu
-
-
-
?
Leu-enkephalin + H2O
Tyr-Gly + Gly-Phe-Leu
-
-
-
-
?
Leu-Gly-2-naphthylamide + H2O
Leu-Gly + 2-naphthylamine
-
no reaction
-
-
?
Leu-Gly-2-naphthylamide + H2O
Leu-Gly + 2-naphthylamine
-
-
-
-
?
Leu-Gly-2-naphthylamide + H2O
Leu-Gly + 2-naphthylamine
-
-
-
-
?
Lys-Ala-2-naphthylamide + H2O
Lys-Ala + 2-naphthylamine
-
-
-
-
?
Lys-Ala-2-naphthylamide + H2O
Lys-Ala + 2-naphthylamine
-
-
-
-
?
Lys-Ala-4-methoxy-2-naphthylamide + H2O
Lys-Ala + 4-methoxy-2-naphthylamine
-
poor substrate
-
?
Lys-Ala-4-methoxy-2-naphthylamide + H2O
Lys-Ala + 4-methoxy-2-naphthylamine
-
-
-
-
?
Lys-Ala-4-methoxy-2-naphthylamide + H2O
Lys-Ala + 4-methoxy-2-naphthylamine
-
poor substrate
-
?
Phe-Arg-2-naphthylamide + H2O
Phe-Arg + 2-naphthylamine
poor substrate
-
-
?
Phe-Arg-2-naphthylamide + H2O
Phe-Arg + 2-naphthylamine
-
-
-
?
Phe-Arg-2-naphthylamide + H2O
Phe-Arg + 2-naphthylamine
-
-
-
?
Phe-Arg-2-naphtylamide + H2O
Phe-Arg + 2-naphthylamine
129% of the activity with Arg-Arg-2-naphtylamide
-
-
?
Phe-Arg-2-naphtylamide + H2O
Phe-Arg + 2-naphthylamine
129% of the activity with Arg-Arg-2-naphtylamide
-
-
?
Pro-Arg-2-naphthylamide + H2O
Pro-Arg + 2-naphthylamine
-
-
-
?
Pro-Arg-2-naphthylamide + H2O
Pro-Arg + 2-naphthylamine
-
-
-
?
Tyr-Gly-Gly-Phe + H2O
Tyr-Gly + Gly-Phe
-
enkephalin, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
-
-
?
Tyr-Gly-Gly-Phe + H2O
Tyr-Gly + Gly-Phe
-
-
-
?
Tyr-Gly-Gly-Phe-Leu + H2O
Tyr-Gly + Gly-Phe-Leu
-
Leu-enkephalin, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
-
-
?
Tyr-Gly-Gly-Phe-Leu + H2O
Tyr-Gly + Gly-Phe-Leu
-
-
-
-
?
additional information
?
-
enzyme additionally hydrolyzes isopentenyl diphosphate and dephosphorylates purine nucleotides ADP, dGDP, dGTP, and 8-oxo-dATP with strong preference for oxidized dATP
-
-
?
additional information
?
-
-
enzyme additionally hydrolyzes isopentenyl diphosphate and dephosphorylates purine nucleotides ADP, dGDP, dGTP, and 8-oxo-dATP with strong preference for oxidized dATP
-
-
?
additional information
?
-
-
polypeptides having unsubstituted N-termini, Gly4, Glu4, tripeptides and bonds involving proline are resistant
-
-
?
additional information
?
-
-
polypeptides having unsubstituted N-termini, Gly4, Glu4, tripeptides and bonds involving proline are resistant
-
-
?
additional information
?
-
-
Ala-Ala-Ala, action of goat brain DPP-III on the peptide is investigated, substrate is not hydrolyzed
no activity
-
?
additional information
?
-
-
Gly-Phe-Leu, action of goat brain DPP-III on the peptide is investigated, substrate is not hydrolyzed
no activity
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
hydrolysis depending on type of amino acid and chain length
-
-
?
additional information
?
-
-
enzyme prefers a hydrophobic residue at P1 position
-
?
additional information
?
-
-
no substrates: Arg-4-methyl-beta-naphthylamide, Ser-beta-naphthylamide, Leu-beta-naphthylamide, Pro-beta-naphthylamide, Val-beta-naphthylamide, Asp-beta-naphthylamide, Ile-beta-naphthylamide, Phe-beta-naphthylamide, Tyr-beta-naphthylamide, Trp-beta-naphthylamide, Gly-beta-naphthylamide, Arg-Phe-Ala-beta-naphthylamide, Gly-Pro-Leu-beta-naphthylamide, benzyloxycarbonyl-Phe-Arg-4-methyl-beta-naphthylamide, N-benzoyl-DL-Arg-beta-naphthylamide
-
-
?
additional information
?
-
enzyme additionally hydrolyzes isopentenyl diphosphate and dephosphorylates purine nucleotides ADP, dGDP, dGTP, and 8-oxo-dATP with strong preference for oxidized dATP
-
-
?
additional information
?
-
-
enzyme additionally hydrolyzes isopentenyl diphosphate and dephosphorylates purine nucleotides ADP, dGDP, dGTP, and 8-oxo-dATP with strong preference for oxidized dATP
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
hydrolysis depending on type of amino acid and chain length
-
-
?
additional information
?
-
-
hydrolysis depending on type of amino acid and chain length
-
-
?
additional information
?
-
-
enzyme prefers a hydrophobic residue at P1 position
-
?
additional information
?
-
-
no or very poor substrates: Gly-Phe-naphthylamide, Leu-Ala-2-naphthylamide, Ser-Met-2-naphthylamide, Gly-Ala-2-naphthylamide, Phe-Arg-2-naphthylamide, His-Phe-naphthylamide, Arg-4-methoxy-2-naphthylamide, Ser-2-naphthylamide, Leu-2-naphthylamide, Pro-2-naphthylamide, Val-2-naphthylamide, M-Gly-Arg-2-naphthylamide, Gly-Pro-Leu-2-naphthylamide, Val-Lys-Lys-Arg-4-methoxy-2-naphthylamide, benzoyl-DL-Arg-2-naphthylamide, Z-Arg-Arg-4-methoxy-2-naphthylamide
-
-
?
additional information
additional information
-
-
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, angiotensin I, action of goat brain DPP-III on the peptide is investigated, substrate is not hydrolyzed
no activity
-
?
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1,3-di-[5-(2-imidazolinyl)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-furyl)-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-thienyl)-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-thienyl)-cyclobutanedihydrochloride
-
-
1,3-di-[5-(N-amidino)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(N-amidino)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-o-chlorophenylcyclobutane dihydrochloride
-
-
1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride
-
-
1-ethyl-3(3-dimethyl-amino-propyl)-carbodiimide*HCl
-
1.0 mM inhibitor, 29% inhibition, 5.0 mM inhibitor, 64% inhibition
2,2'-dithiodipyridine
-
1.0 mM inhibitor, 32% inhibition, 2.5 mM inhibitor, 98% inhibition
2,4,6-trinitrobenzene sufonic acid trihydrate
-
1.0 mM inhibitor, 52% inhibition, 2.5 mM inhibitor, 89% inhibition
2-(3H-imidazol-4-yl)-1H-benzoimidazole-5-carboxamidine hydrochloride
-
complete inhibition at 0.1 mM
2-(3H-imidazol-4-yl)-1H-benzoimidazole-5-imidazolinylamidine hydrochloride
-
complete inhibition at 0.1 mM
2-[(E)-2-phenylethenyl]-1H-benzimidazole
-
-
3,3'-dithiobis(6-nitrobenzoic acid)
-
13% residual activity at 2.5 mM, beta-mercaptoethanol and dithiothreitlol completely restores enzyme activity
4,4'-dithiodipyridine
inactivation of wild-type dipeptidyl peptidase III after incubation at pH 8.0 at 25°C, after 5 min incubation loss of 30% enzyme activity, after 15 min incubation loss of 62% enzyme activity
4-(2-aminoethyl) benzenesulfonyl fluoride
-
0.01 mM, 89% inhibition
4-Chlorobenzoic acid
-
0.5 mM, 42% inhibition
4-nitrophenyl iodoacetate
-
0.5 mM, 57% inhibition
5,5'-dithiobis(2-nitrobenzoate)
6-(4,5-dihydro-1H-imidazol-2-yl)-2-[(E)-2-phenylethenyl]-1H-benzimidazole
Acetyl-L-Leu-L-arginal
-
-
AEBSF
-
0.2 mM, 84% inhibition
alpha1 anti-trypsin
-
1.0 mM inhibitor, 61% inhibition
-
amastatin
-
30% inhibition at 0.1 mM
amino([(5-([(2R)-1-methoxy-3-(6-methylphenanthridin-8-yl)-1-oxopropan-2-yl]carbamoyl)-1H-pyrrol-2-yl)carbonyl]amino)methaniminium chloride
0.035 mM, 45% inhibition
amino[((5-[(2-([(2R)-1-methoxy-3-(6-methylphenanthridin-8-yl)-1-oxopropan-2-yl]amino)-2-oxoethyl)carbamoyl]-1H-pyrrol-2-yl)carbonyl)amino]methaniminium chloride
0.06 mM, 33% inhibition
Arg-Arg-2-naphthylamide
-
above 0.1 mM
benzamidine HCl
-
1.0 mM inhibitor, 29% inhibition, 5.0 mM inhibitor, 61% inhibition
bis-p-nitrophenyl phosphate
-
-
Ca2+
-
0.2 mM, 40% inhibition
Co2+
-
activation up to 50% at 0.001-0.0001 mM, inbhibitory above 0.002 mM
diisopropylfluorophosphate
dimethyl sulfoxide
-
inhibitory effect with more than 5% (v/v) dimethyl sulfoxide
DTNB
-
1.0 mM inhibitor, 54% inhibition, 2.5 mM inhibitor, 87% inhibition
E-64
-
i.e. L-trans-epoxysuccinyl-leucylamido(4-guanidino)butane, 10% inhibition at 0.1 mM
Egg white trypsin inhibitor
-
1.0 mM inhibitor, 34% inhibition
-
EGTA
96% inhibition in the presence of 1 mM EGTA, but 110% activity in the presence of the two inhibitors 1 mM EGTA and 1 mM Zn2+
ethanol
-
the enzyme loses about half of its activity at 5% (v/v) ethanol
Gly-L-Glu
-
36% inhibition at 1 mM
Gly-L-Phe
-
46% inhibition at 1 mM
Gly-L-Phe-L-Leu
-
non-competitive inhibitor, 82% inhibition at 1 mM
iodoacetic acid
-
1.0 mM inhibitor, 25% inhibition, 5.0 mM inhibitor, 48% inhibition
IVYPW
-
hemorphin.like peptide, non-competitive, 50% inhibition at 0.00016 mM
L-Ala-L-Ala-L-Ala
-
4% inhibition at 1 mM
L-Ala-L-Ala-L-Ala-L-Ala
-
58% inhibition at 0.5 mM
L-Arg-L-Phe
-
56% inhibition at 1 mM
L-Arg-L-Phe-L-Ala
-
competitive inhibitor, 99% inhibition at 1 mM
L-Arg-L-Trp
-
46% inhibition at 1 mM
L-Arg-L-Val
-
49% inhibition at 1 mM
L-Asp-L-Ala
-
25% inhibition at 1 mM
L-His-L-Leu
-
76% inhibition at 1 mM
L-His-L-Lys
-
41% inhibition at 1 mM
L-His-L-Phe
-
46% inhibition at 1 mM
L-His-L-Pro
-
16% inhibition at 1 mM
L-Ile-L-His
-
34% inhibition at 1 mM
L-Leu-L-Arg
-
complete inhibition at 0.5 mM
L-Leu-L-Trp
-
competitive inhibitor, 90% inhibition at 1 mM
L-Leu-L-Trp-L-Met
-
competitive inhibitor, 92% inhibition at 1 mM
L-Leu-L-Trp-L-Met-L-Arg-L-Phe-L-Ala
-
competitive inhibitor, complete inhibition at 1 mM
L-Lys-L-Ala
-
23% inhibition at 1 mM
L-Met-L-Arg
-
99% inhibition at 1 mM
L-Phe-L-Ala
-
41% inhibition at 1 mM
L-Phe-L-Arg
-
75% inhibition at 1 mM
L-Phe-L-Leu
-
58% inhibition at 1 mM
L-Phe-L-Met
-
85% inhibition at 1 mM
L-Pro-L-Arg-OH
-
54% inhibition at 1 mM
L-Pro-L-Glu
-
34% inhibition at 1 mM
L-Pro-L-Phe
-
56% inhibition at 1 mM
L-Ser-L-Met
-
32% inhibition at 1 mM
L-Trp-L-Met
-
competitive inhibitor, 94% inhibition at 1 mM
L-Trp-L-Met-L-Asp-L-Phe
-
82% inhibition at 1 mM
L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
-
competitive inhibition
L-Tyr-Gly
-
31% inhibition at 1 mM
L-Tyr-Gly-Gly-L-Phe
-
53% inhibition at 1 mM
L-Tyr-L-Ile
-
72% inhibition at 1 mM
L-tyrosyl-glycine hydroxamic acid
-
L-tyrosyl-L-phenylalanine hydroxamic acid
-
L-Val-L-Tyr
-
competitive inhibitor, 84% inhibition at 1 mM
Leu-enkephalin
-
i.e. L-Tyr-Gly-Gly-L-Phe-L-Leu, 92% inhibition at 1 mM, competitive inhibitor
Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg
-
Leu-valorphin-Arg
Li+
-
73.0% residual activity at 0.1 mM
Met-enkephalin
-
i.e. L-Tyr-Gly-Gly-L-Phe-L-Met, 61% inhibition at 0.5 mM, competitive inhibitor
methyl N-[5-(carbamimidoylcarbamoyl)-1H-pyrrole-2-carbonyl]-3-[[(pyren-1-yl)methyl]amino]-D-alaninate
0.01 mM, 36% inhibition. Compound is not hydrolysed by enzyme, although the binding affinity is comparable with that of Arg-Arg-2-naphthylamide
N-hydroxy-succinimide
-
1.0 mM inhibitor, 30% inhibition, 5.0 mM inhibitor, 51% inhibition
Nalpha-tosyl-L-Phe-chloromethyl ketone
-
60% inhibition at 0.1 mM
p-aminophenyl mercuric acetate
-
1.0 mM inhibitor, 42% inhibition, 2.5 mM inhibitor, 94% inhibition
p-chloromercuriphenylsulfonic acid
-
-
p-Chlorophenylsulfonate
-
-
p-hydroxymercuriphenyl-sulfonic acid
-
1.0 mM inhibitor, 22% inhibition, 2.5 mM inhibitor, 96% inhibition
p-nitrocatecholsulfate
-
1.0 mM inhibitor, 37% inhibition, 5.0 mM inhibitor, 58% inhibition
Pb(CH3COO)2
-
1.0 mM inhibitor, 53% inhibition, 2.5 mM inhibitor, 97% inhibition
pepstatin
-
1 mM, 43% inhibition
pepstatin A
-
5.0 mM inhibitor, 92% inhibition
Phenylmethanesulfonylfluoride
probestin
-
85% inhibition at 0.1 mM
Propioxanthin A and B
-
-
-
Soybean trypsin inhibitor
-
1.0 mM inhibitor, 64% inhibition, 2.5 mM inhibitor, 76% inhibition
-
TLCK
-
1.0 mM inhibitor, 27% inhibition, 5.0 mM inhibitor, 63% inhibition
TPCK
-
1.0 mM inhibitor, 75% inhibition, 5.0 mM inhibitor, 88% inhibition
Tyr(SO3H)-Gly-Gly-Phe-Leu
-
-
Tyr-Ala-Gly-Phe-Leu
-
Ala2-Leu-enkephalin
Tyr-D-Ala-Gly-Phe-Leu
-
D-Ala2-Leu-enkephalin
Tyr-Gly-Gly-Phe
-
enkephalin fragment
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile
-
dynorphin A 1-8
Tyr-Pro-Phe-Phe-NH2
-
endomorphin-2
Tyr-Pro-Phe-Val-Glu-Pro-Ile
-
human beta-casomorphin
Tyr-Pro-Trp-Phe-NH2
-
endomorphin-1
Urea
-
sensitive to very low concentrations of urea
Val-Val-Tyr-Pro-Trp-Thr-Gln
-
valorphin
WVYPW
-
hemorphin.like peptide, non-competitive, 50% inhibition at 0.00024 mM
1,10-phenanthroline
-
-
1,10-phenanthroline
Schistosoma sp.
-
-
1,10-phenanthroline
-
2.5 mM, 62% inhibition
2-mercaptoethanol
-
-
3,4-dichloroisocoumarin
-
-
3,4-dichloroisocoumarin
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
reactivation by DTT or 2-mercaptoethanol
5,5'-dithiobis(2-nitrobenzoate)
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
1 mM, 57% inhibition
6-(4,5-dihydro-1H-imidazol-2-yl)-2-[(E)-2-phenylethenyl]-1H-benzimidazole
-
-
6-(4,5-dihydro-1H-imidazol-2-yl)-2-[(E)-2-phenylethenyl]-1H-benzimidazole
0.01 mM, 97.8% inhibition
angiotensin II
-
-
angiotensin III
-
-
Aprotinin
-
1.0 mM inhibitor, 59% inhibition, 5.0 mM inhibitor, 99% inhibition
Arg-Arg
-
-
bestatin
-
10% inhibition at 0.1 mM
bestatin
-
35% inhibition at 0.1 mM
bestatin
-
0.01 mM, 41% inhibition
Cd2+
-
-
Cu2+
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
dithiothreitol
-
-
EDTA
-
-
EDTA
complete loss of activity
EDTA
-
1.0 mM inhibitor, 50% inhibition, 5.0 mM inhibitor, 64% inhibition
EDTA
-
49.2% residual activity at 1 mM
EDTA
-
67% inhibition at 5 mM
EDTA
-
10 mM, 60% inhibition
EDTA
-
1 mM, 19% inhibition
Gly-Gly-Phe-Leu
-
fragment of Leu-enkephalin
Gly-Gly-Phe-Leu
-
enkephalin fragment
Gly-Gly-Phe-Leu
-
fragment of Leu-enkephalin
H-Phe-Gly-NHOH
competitive
H-Phe-Gly-NHOH
competitive
H-Phe-Leu-NHOH
competitive
H-Phe-Leu-NHOH
competitive
H-Phe-Phe-NHOH
competitive
H-Phe-Phe-NHOH
competitive
H-Tyr-Phe-NHOH
competitive
H-Tyr-Phe-NHOH
competitive
Hg2+
-
11.1% residual activity at 0.1 mM
His-Phe-Arg-Trp
-
fragment of alpha-melanocyte-stimulating hormone
His-Phe-Arg-Trp
-
fragment of alpha-melanocyte-stimulating hormone
iodoacetamide
-
1.0 mM inhibitor, 27% inhibition, 5.0 mM inhibitor, 42% inhibition
iodoacetamide
-
0.1 mM, 57% inhibition
K+
-
82.0% residual activity at 0.1 mM
K+
-
0.2 mM, 40% inhibition
Leu-Trp-Met-Arg-Phe
-
-
leupeptin
-
1.0 mM inhibitor, 32% inhibition
leupeptin
-
10% inhibition at 0.1 mM
leupeptin
-
0.1 mM, 71% inhibition
leupeptin
-
0.005 mM, 78% inhibition
Lys-Val-Ile-Leu-Phe
-
fragment of hydra head activator
Lys-Val-Ile-Leu-Phe
-
fragment of hydra head activator
Mg2+
-
0.2 mM, 60% inhibition
Mn2+
-
0.2 mM, 80% inhibition
N-ethylmaleimide
-
1.0 mM inhibitor, 29% inhibition, 2.5 mM inhibitor, 88% inhibition, 5.0 mM inhibitor, 96% inhibition
N-ethylmaleimide
-
complete inhibition at 2 mM
N-ethylmaleimide
-
1 mM, 93% inhibition
Ni2+
-
12.4% residual activity at 0.1 mM
o-phenanthroline
complete loss of activity
o-phenanthroline
-
1.0 mM inhibitor, 46% inhibition, 2.5 mM inhibitor, 85% inhibition, 5.0 mM inhibitor, 96% inhibition
o-phenanthroline
-
93% inhibition at 1 mM
o-phenanthroline
-
1 mM, 70% inhibition
o-phenanthroline
-
50% inhibition at 0.1 mM
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
not with Leu-enkephalin as substrate
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
complete inhibition at 0.001 mM
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-hydroxymercuribenzoate
-
reactivation by reduced glutathione or mercaptoethanol
p-hydroxymercuribenzoate
-
-
Phenylmethanesulfonylfluoride
-
-
Phenylmethanesulfonylfluoride
-
-
PMSF
-
1.0 mM inhibitor, 53% inhibition, 2.5 mM inhibitor, 87% inhibition
PMSF
-
0.2 mM, 88% inhibition
PMSF
-
40% inhibition at 1 mM
PMSF
-
0.5 mM, 30% inhibition
Proctolin
-
-
puromycin
-
-
puromycin
-
1.0 mM inhibitor, 30% inhibition, 5.0 mM inhibitor, 58% inhibition
puromycin
-
15% inhibition at 0.1 mM
tynorphin
-
-
tynorphin
-
50% inhibition at 0.00062 mM
tynorphin
Val-Val-Tyr-Pro-Trp, 10 microM, 99% inhibition
tynorphin
-
i.e. VVYPW, 50% inhibition at 0.000086 mM, competitive
Tyr-Arg
-
-
Tyr-Gly-Gly-Phe-Leu
-
Leu-enkephalin
Tyr-Gly-Gly-Phe-Leu
-
Leu-enkephalin
Tyr-Gly-Gly-Phe-Met
-
Met-enkephalin
Tyr-Gly-Gly-Phe-Met
-
Met-enkephalin
Tyr-Phe-NHOH
-
Tyr-Tyr
-
-
Zn2+
-
-
Zn2+
-
50.3% residual activity at 1 mM
Zn2+
19% inhibition in the presence of 0.1 mM Zn2+, 99.8% inhibition in the presence of 1 mM Zn2+
Zn2+
-
50% inhibition at 0.032 mM
Zn2+
-
0.2 mM, 80% inhibition
Zn2+
-
50% inhibition at 0.001 mM
Zn2+
10 micromol, strong inhibition
additional information
activities in phosphate buffers are singnificantly lower than in Tris-Hcl buffer
-
additional information
-
activities in phosphate buffers are singnificantly lower than in Tris-Hcl buffer
-
additional information
-
not inhibited by beta-mercaptoethanol
-
additional information
-
structural requirements for inhibition by hemorphin-like peptides
-
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McDonald, J.K.; Schwabe, C.
Dipeptidyl aminopeptidase III (EC 3.4.14.-)
Proteinases in Mammalian Cells and Tissues (Barrett, A. J. , ed. )
361-364
1977
Bos taurus, Rattus norvegicus
-
brenda
Alba, F.; Arenas, J.C.; Lopez, M.A.
Properties of rat brain dipeptidyl aminopeptidases in the presence of detergents
Peptides
16
325-329
1995
Rattus norvegicus
brenda
Shimamori, Y.; Watanabe, Y.; Fujimoto, Y.
Human placental dipeptidyl aminopeptidase III: Hydrolysis of enkephalins and its stimulation by cobaltus ions
Biochem. Med. Metab. Biol.
40
305-310
1988
Homo sapiens
brenda
Vanha-Perttula, T.
Dipeptidyl peptidase III and alanyl aminopeptidase in the human seminal plasma: Origin and biochemical properties
Clin. Chim. Acta
177
179-196
1988
Homo sapiens
brenda
Abramic, M.; Zubanovic, M.; Vitale, L.
Dipeptidyl peptidase III from human erythrocytes
Biol. Chem. Hoppe-Seyler
369
29-38
1988
Homo sapiens
brenda
Inaoka, Y.; Tamaoki, H.
Purification and characterization of enkephalinase B from rat brain membrane
Biochim. Biophys. Acta
925
27-35
1987
Rattus norvegicus
brenda
Chan., S.A.T.; Jones, T.H.D.; Sweeney, J.P.; Toursarkissian, K.
Partial purification and characterization of dipeptidyl-aminopeptidase III from Dictostelium discoideum
Exp. Mycol.
11
27-35
1987
Dictyostelium discoideum
-
brenda
Shimamori, Y.; Watanabe, Y.; Fujimoto, Y.
Purification and characterization of dipeptidyl aminopeptidase III from human placenta
Chem. Pharm. Bull.
34
3333-3340
1986
Homo sapiens
brenda
Nishikiori, T.; Kawahara, F.; Naganawa, H.; Muraoka, Y.; Aoyagi, T.; Umezawa, H.
Production of acetyl-L-leucyl-L-argininal, inhibitor of dipeptidyl aminopeptidase III by bacteria
J. Antibiot.
37
680-681
1984
Rattus norvegicus
brenda
Lee, C.M.; Snyder, S.H.
Dipeptidyl-aminopeptidase III of rat brain. Selective affinity for enkephalin and angiotensin
J. Biol. Chem.
257
12043-12050
1982
Rattus norvegicus
brenda
Jones, T.H.D.; Kapralou, A.
A rapid assay for dipeptidyl aminopeptidase III in human erythrocytes
Anal. Biochem.
119
418-423
1982
Homo sapiens
brenda
Swanson, A.A; Albers-Jackson, B.; McDonald, J.K.
Mammalian lens dipeptidyl aminopeptidase III
Biochem. Biophys. Res. Commun.
84
1151-1159
1978
Bos taurus
brenda
Fukasawa, K.; Fukasawa, K.M.; Kanai, M.; Fujii, S.; Hirose, J.; Harada, M.
Dipeptidyl peptidase III is a zinc metallo-exopeptidase
Biochem. J.
329
275-282
1998
Homo sapiens
brenda
Fukasawa, K.; Fukasawa, K.M.; Iwamoto, G.; Hirose, J.; Harada, M.
The HELLGH motif of rat liver dipeptidyl peptidase III is involved in zinc coordination and the catalytic activity of the enzyme
Biochemistry
38
8299-8303
1999
Rattus norvegicus
brenda
Huang, J.; Kim, J.; Ramamurthy, P.; Jones, T.H.D.
The purification, specificity, and role of dipeptidyl peptidase III in Dictostelium discoideum
Exp. Mycol.
16
102-109
1992
Dictyostelium discoideum
-
brenda
Simaga, S.; Babic, D.; Osmak, M.; Ilic-Forko, J.; Vitale, L.; Milicic, D.; Abramic, M.
Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue
Eur. J. Cancer
34
399-405
1998
Homo sapiens
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Identification of the reactive cysteine residues in yeast dipeptidyl peptidase III
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Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts
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Flexibility of the coordination geometry around the cupric ions in Cu(II)-rat dipeptidyl peptidase III is important for the expression of enzyme activity
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Aspartate 496 from the subsite S2 drives specificity of human dipeptidyl peptidase III
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Importance of the three basic residues in the vicinity of the zinc-binding motifs for the activity of the yeast dipeptidyl peptidase III
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Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III
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Homo sapiens (Q9NY33), Homo sapiens
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Isolation, purification and biochemical characterization of dipeptidyl peptidase-III from germinated Vigna radiata seeds
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Vigna radiata
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Rastija, V.; Agic, D.; Tomic, S.; Nikolic, S.; Hranjec, M.; Grace, K.Z.; Abramic, M.
Synthesis, QSAR, and molecular dynamics simulation of amidino-substituted benzimidazoles as dipeptidyl peptidase III inhibitors
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Homo sapiens (Q9NY33), Homo sapiens
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Karacic, Z.; Vukelic, B.; Ho, G.; Jozic, I.; Sucec, I.; Salopek-Sondi, B.; Kozlovic, M.; Brenner, S.; Ludwig-Mueller, J.; Abramic, M.
A novel plant enzyme with dual activity An atypical Nudix hydrolase and a dipeptidyl peptidase III
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Physcomitrium patens (A9TLP4), Physcomitrium patens, Arabidopsis thaliana (Q8L831), Arabidopsis thaliana
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Validation of flavonoids as potential dipeptidyl peptidase III inhibitors Experimental and computational approach
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Homo sapiens (Q9NY33), Homo sapiens
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Agic, D.; Brkic, H.; Kazazic, S.; Tomic, A.; Abramic, M.
Aprotinin interacts with substrate-binding site of human dipeptidyl peptidase III
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Homo sapiens (Q9NY33), Homo sapiens
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Cvitesic, A.; Sabljic, I.; Makarevic, J.; Abramic, M.
Novel dipeptidyl hydroxamic acids that inhibit human and bacterial dipeptidyl peptidase III
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Bacteroides thetaiotaomicron (Q8A6N1), Bacteroides thetaiotaomicron, Homo sapiens (Q9NY33), Homo sapiens, Bacteroides thetaiotaomicron DSM 2079 (Q8A6N1)
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Prajapati, S.C.; Chauhan, S.S.
Human dipeptidyl peptidase III mRNA variant I and II are expressed concurrently in multiple tumor derived cell lines and translated at comparable efficiency in vitro
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Homo sapiens
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Attri, P.; Jodha, D.; Singh, J.; Dhanda, S.
Purification, kinetic and functional characterization of membrane bound dipeptidyl peptidase-III from NCDC 252 a probiotic lactic acid bacteria
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Pediococcus acidilactici
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Tomin, M.; Tomic, S.
Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity - a computational study
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Bacteroides thetaiotaomicron
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Sabljic, I.; Mestrovic, N.; Vukelic, B.; Macheroux, P.; Gruber, K.; Luic, M.; Abramic, M.
Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides thetaiotaomicron
PLoS ONE
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Bacteroides thetaiotaomicron (Q8A6N1), Bacteroides thetaiotaomicron, Bacteroides thetaiotaomicron DSM 2079 (Q8A6N1)
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Hromic-Jahjefendic, A.; Jajcanin Jozic, N.; Kazazic, S.; Grabar Branilovic, M.; Karacic, Z.; Schrittwieser, J.H.; Das, K.M.P.; Tomin, M.; Oberer, M.; Gruber, K.; Abramic, M.; Tomic, S.
A novel Porphyromonas gingivalis enzyme An atypical dipeptidyl peptidase III with an ARM repeat domain
PLoS ONE
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Porphyromonas gingivalis (Q7MX92), Porphyromonas gingivalis
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Sabljic, I.; Tomin, M.; Matovina, M.; Sucec, I.; Tomacic Paic, A.; Tomic, A.; Abramic, M.; Tomic, S.
The first dipeptidyl peptidase III from a thermophile Structural basis for thermal stability and reduced activity
PLoS ONE
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Caldithrix abyssi (H1XW48), Caldithrix abyssi, Caldithrix abyssi DSM 13497 (H1XW48)
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Matic, J.; Supljika, F.; Tir, N.; Piotrowski, P.; Schmuck, C.; Abramic, M.; Piantanida, I.; Tomic, S.
Guanidiniocarbonyl-pyrrole-aryl conjugates as inhibitors of human dipeptidyl peptidase III Combined experimental and computational study
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Homo sapiens (Q9NY33)
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Matovina, M.; Agic, D.; Abramic, M.; Matic, S.; Karacic, Z.; Tomic, S.
New findings about human dipeptidyl peptidase III based on mutations found in cancer
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Homo sapiens (Q9NY33)
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