Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carbenoxolone | potent and selective 11beta-HSD1 inhibitor | Oryctolagus cuniculus | |
PF-3319913 | potent and selective 11beta-HSD1 inhibitor, a 1% dose of PF-3319913 inhibits in vivo 11beta-HSD1 enzyme activity in the rabbit eye by 100% at 2 h | Oryctolagus cuniculus | |
PF-3859622 | potent and selective 11beta-HSD1 inhibitor, a 2% dose of PF-3859622 consistently inhibits in vivo 11beta-HSD1 enzyme activity in the rabbit eye by 100% at 6 and 12 h, a 0.2% dose of PF-3859622 causes 81% inhibition of cortisone conversion at 6 h | Oryctolagus cuniculus | |
PF-904955 | potent and selective 11beta-HSD1 inhibitor, a 1% dose of PF-904955 inhibits in vivo 11beta-HSD1 enzyme activity in the rabbit eye by 88% at 2 h | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | 11beta-HSD1 is widely expressed in the eye, particularly ciliary epithelium | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NADP+ | - |
Oryctolagus cuniculus | cortisone + NADPH | - |
r |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Oryctolagus cuniculus |
11beta-hydroxysteroid dehydrogenase-1 | - |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Oryctolagus cuniculus |