Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carbenoxolone | - |
Homo sapiens | |
PF-877423 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Homo sapiens | - |
cortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
myoblast | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | isoform 11beta-HSD1 enzyme activity is decreased in diabetic subjects | down |
Homo sapiens | isoform 11beta-HSD1 mRNA expression and enzyme activity is up-regulated by physiological concentrations of cortisol. After treatment with dexamethasone, isoform 11beta-HSD1 mRNA expression increases in both diabetics and controls | up |
General Information | Comment | Organism |
---|---|---|
metabolism | prereceptor glucocorticoid metabolism by 11beta-HSD1 is implicated in the pathogenesis of the metabolic syndrome | Homo sapiens |