Inhibitors | Comment | Organism | Structure |
---|---|---|---|
21-Hydroxy-5alpha-pregnane-3,20-dione | - |
Cavia porcellus | |
3,3-Tetramethyleneglutaric acid | enzyme form CR2 inhibited, CR1 slightly | Cavia porcellus | |
5beta-androstane-3alpha,17beta-diol | - |
Cavia porcellus | |
5beta-pregnane-3,20-dione | - |
Cavia porcellus | |
AgNO3 | enzyme form CR1 inhibited, CR2 not | Cavia porcellus | |
Ammonium molybdate | enzyme form CR1 inhibited, CR2 not | Cavia porcellus | |
androsterone | CR2 inhibited, CR1 not | Cavia porcellus | |
chlorpromazine | - |
Cavia porcellus | |
dicoumarol | enzyme form CR2 inhibited, CR1 not | Cavia porcellus | |
Hg2+ | - |
Cavia porcellus | |
indomethacin | - |
Cavia porcellus | |
p-chloromercuribenzoate | - |
Cavia porcellus | |
progesterone | - |
Cavia porcellus | |
quercitrin | - |
Cavia porcellus | |
Sodium phenobarbitone | enzyme form CR2 inhibited, CR1 slightly | Cavia porcellus | |
testosterone | - |
Cavia porcellus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | overview | Cavia porcellus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
4 * 32000, enzyme form CR2, SDS-PAGE | Cavia porcellus |
34000 | - |
gel filtration, enzyme form CR1 | Cavia porcellus |
37500 | - |
1 * 37500, enzyme form CR1, SDS-PAGE | Cavia porcellus |
115000 | - |
gel filtration, enzyme form CR2 | Cavia porcellus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
2 enzyme forms: major form CR2, minor form CR1 | Cavia porcellus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Cavia porcellus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Cavia porcellus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-nitrobenzaldehyde + NADPH | - |
Cavia porcellus | 2-nitrobenzyl alcohol + NADP+ | - |
? | |
3-nitroacetophenone + NADPH | - |
Cavia porcellus | ? | - |
? | |
3-nitrobenzaldehyde + NADPH | - |
Cavia porcellus | 3-nitrobenzyl alcohol + NADP+ | - |
? | |
4-nitroacetophenone + NADPH | - |
Cavia porcellus | ? | - |
? | |
4-nitrobenzaldehyde + NADPH | - |
Cavia porcellus | 4-nitrobenzyl alcohol + NADP+ | - |
? | |
benzaldehyde + NADPH | - |
Cavia porcellus | benzyl alcohol + NADP+ | - |
? | |
diacetyl + NADPH | - |
Cavia porcellus | ? | - |
? | |
additional information | overview | Cavia porcellus | ? | - |
? | |
additional information | specificity of various enzyme forms | Cavia porcellus | ? | - |
? | |
phenylglyoxal + NADPH | - |
Cavia porcellus | ? | - |
? | |
pyridine-4-aldehyde + NADPH | - |
Cavia porcellus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 37500, enzyme form CR1, SDS-PAGE | Cavia porcellus |
tetramer | 4 * 32000, enzyme form CR2, SDS-PAGE | Cavia porcellus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.8 | 5.3 | 4-nitroacetophenone, pyridine 4-aldehyde, 5beta-dihydrotestosterone, enzyme CR2 | Cavia porcellus |
5.8 | 6.2 | 4-nitroacetophenone, pyridine 4-aldehyde, enzyme form CR1 | Cavia porcellus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Cavia porcellus | |
NADPH | - |
Cavia porcellus |